Now showing items 1-20 of 233

  • Eicosanoids and exosomes : a link between macrophages and lung cancer 

    Lukic, Ana (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-11-01)
    Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these ...
  • Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition 

    Rebrova, Eva Maria (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-10-27)
    The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. Understanding of the cell wall maintenance and ...
  • Molecular and cellular characterization of midbrain dopaminergic neuron development 

    Gyllborg, Daniel (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-08-18)
    Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic ...
  • The role of CTLA-4 in health and autoimmune disease 

    Klocke, Katrin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-19)
    FOXP3+ regulatory T (Treg) cells are powerful regulators of the immune system, as shown by the development of multi-organ autoimmunity in mice and men upon loss or dysfunction of these cells. Whilst Treg cells are vital ...
  • Calcium signaling and network activity : mathematical modeling and molecular mechanisms 

    Smedler, Erik (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-17)
    The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability ...
  • Computational exploration of the medium-chain dehydrogenase/reductase superfamily 

    Östberg, Linus J. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-05-11)
    The medium-chain dehydrogenase/reductase (MDR) superfamily is a protein family with more than 170,000 members across all phylogenetic branches. In humans there are 18 representatives. The entire MDR superfamily contains ...
  • Discovering cell-type dynamics in the nervous system by single-cell transcriptomics 

    Hochgerner, Hannah (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-21)
    The mammalian nervous system is arguably the most intricate system known to science. At its basis lie highly specialized single cells, specifically interacting to ensure everything from normal functionality to complex ...
  • Cysteine biosynthesis in Mycobacterium tuberculosis as potential drug target 

    Brunner, Katharina (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-20)
    The bacterium Mycobacterium tuberculosis is the underlying cause of tuberculosis, one of the most devastating infectious diseases, causing 1.4 million deaths in 2015. In addition one third of the global population is ...
  • Advancing bioinformatics methods for in-depth proteome analysis based on high-resolution mass spectrometry 

    Zhang, Bo (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-19)
    Mass spectrometry-based shotgun proteomics has become one of the essential techniques for comprehensive studies of living systems. Due to the inherent complexity of proteomes and the data, bioinformatics plays a critical ...
  • Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense 

    Tang, Xiao (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-04-05)
    Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive ...
  • Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress 

    Ren, Xiaoyuan (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-03-16)
    Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...
  • Identification of genetic variants and their implications in autoimmunity 

    Norin, Ulrika (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-03-03)
    Autoimmune disorders start to develop when the body’s immune system recognizes organs and tissues as foreign and initiates uncontrolled immune reactions against them. Most of these disorders are regarded as complex with ...
  • Targeting DNA repair pathways for cancer therapy 

    Eshtad, Saeed (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-01-20)
    Accumulation of genomic mutations is the consequence of failure in DNA repair as well as increased exposure to endogenous/environmental mutagens. DNA repair pathways safeguard the human genome from such mutagens, and thereby ...
  • Deciphering Ephrin/Eph signaling pathways in cancer cells using rationally designed ligand nanoclusters 

    Shaw, Alan (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2017-01-05)
    The dynamic link between the nanoscale spatial distribution of biomolecules and their functional impact on cellular and downstream biological behaviors has been hypothesized, but only supported by limited evidences. This ...
  • Mitochondrial disease in children : from clinical presentation to genetic background 

    Naess, Karin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-12-22)
    Mitochondrial disorders are amongst the most common groups of inborn errors of metabolism. They are caused by deficiencies in the final pathway of the cellular energy production, the mitochondrial respiratory chain. The ...
  • Role of platelet-derived growth factor B in cholesterol and glucose metabolism 

    Li, Tian (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-12-15)
    Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe ...
  • Mechanisms controlling midbrain dopaminergic neuron development 

    Yang, Shanzheng (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-25)
    The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated ...
  • Origin of life : testing the isotopic resonance hypothesis 

    Xie, Xueshu (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-09)
    The Miller-Urey (MU) experiment provided evidence supporting the abiogenesis theory, and is considered to be the seminal experiment in the context of origin of life. The MU mixture produced in the experiment is assumed to ...
  • Positional identification and functional analysis of genes regulating autoimmune arthritis 

    Yau, Anthony Chun Yeung (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-11-07)
    The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the ...
  • Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15 

    Hagenkort, Anna (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2016-10-28)
    Synthetic nucleobase- and nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against various forms of cancer. Due to their resemblance to endogenous nucleotides these ...