Now showing items 1-20 of 262

    • Novel methods for mapping genome organization and genome fragility in the 3D space of the nucleus 

      Kallas, Tomasz (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-11-13)
      For over a century, scientists have been trying to understand how the DNA molecule that is so tightly packed in the micro space of the nucleus sustains critical cellular processes such as transcription, replication or the ...
    • Conformational dynamics in microRNAs : the example of miR-34a targeting Sirt1 mRNA 

      Baronti, Lorenzo (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-06-17)
      In biology, regulatory mechanisms are essential to achieve complex tasks, as virtually every process can be positively or negatively modulated in its outcome, upon different cues. In humans, microRNAs (miRNAs) ...
    • Studies of the thioredoxin system in redox signaling and oxidative stress 

      Espinosa Fernández, Belén (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-05-08)
      Reactive oxygen species exert reversible posttranslational modifications in proteins containing redox sensitive thiols, thereby affecting several cellular processes and protein functions. Reductive enzyme systems, such as ...
    • Applications of genomic tools to decode genome function 

      Zhang, Jilin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-27)
      The revolution in sequencing technologies has greatly advanced our understanding of genomes. Many regulatory elements lacking protein-coding ability, such as long non-coding RNAs have been identified and characterized ...
    • 3D imaging and quantitative analysis of intact tissues and organs 

      Kaczyńska, Dagmara (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-17)
      Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ...
    • VEGF-B in islet of langerhans : role in vascular signaling and lipid handling 

      Ning, Frank Chenfei (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-02-13)
      The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies ...
    • Novel methods to study genomic fragility and structural variation 

      Mirzazadeh, Reza (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-11-15)
      DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations ...
    • Electrophysiological and molecular diversity of forebrain interneurons 

      Bengtsson Gonzales, Carolina (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-25)
      Despite their low abundance, telencephalic interneurons demonstrate a great amount of molecular and electrophysiological heterogeneity, suggesting that they exhibit different functions within the circuit. Interneurons ...
    • Single-stranded DNA : methods and application in nanotechnology 

      Bernardinelli, Giulio (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-09-13)
      Basic molecular and cell research, production of recombinant proteins, diagnostic detection of genetic mutations, construction of nanostructures and high-throughput DNA sequencing are only a few examples of the diverse set ...
    • Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation 

      Samudyata, Samudyata (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-08-08)
      Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile ...
    • On GABAergic interneuron diversity and maturation 

      Munguba, Hermany (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-23)
      GABAergic interneurons provide finely, distinct styles of inhibition granted by their unique targeting preferences, molecular profiles, and morphological silhouettes. A central quest of my thesis was to explore what ...
    • Applications of DNA origami encoded nanoscale patterns 

      Fördös, Ferenc (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-15)
      It was almost four decades ago when the recognition of DNA’s potential use as a programmable, self-assembling building material for nanostructures led to the birth and rapid expansion of the field of DNA nanotechnology, ...
    • Shedding light on the STAT3 small molecule inhibitor field 

      Busker, Sander (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-13)
      STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as ...
    • Metabolic disorders : genes and mechanisms 

      Maffezzini, Camilla (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-07)
      Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex ...
    • Specification of enteric neuron subtypes in the developing gut 

      Knoflach, Viktoria (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-06)
      The enteric nervous system (ENS) is the biggest subdivision of the peripheral nervous system and harbors more neurons than the spinal cord. Its intricate network of ganglia is spanning the entire length of the gastrointestinal ...
    • tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS 

      Stefanitsch, Christina (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-05-03)
      The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is ...
    • Effects of design choices on the stiffness of wireframe DNA origami structures 

      Benson, Erik; Mohammed, Abdulmelik; Rayneau-Kirkhope, Daniel; Gådin, Andreas; Orponen, Pekka; Högberg, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24)
    • Regeneration and neural circuits in the spinal cord : an imaging study on zebrafish 

      Dehnisch Ellström, Ivar (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-03-14)
      The reversal of spinal cord injury (SCI) and its devastating effect on voluntary control is one of the most provocative challenges in neuroscience research. Preclinical and clinical research has for a very long time tried ...
    • Molecular mechanisms and targets of new anticancer treatments 

      Saei Dibavar, Amirata (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-02-06)
      The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies ...
    • Decoding the contribution of transcription factors to cell fate determination 

      Wei, Bei (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2018-11-19)
      It is well accepted that transcription factors (TFs) play a crucial role in determining cell identity. Although RNA expression or protein abundance data show that a large fraction of the total TFs are expressed in a given ...