Licentiatavhandlingar / Licentiate Theses - C1 (MTC): Recent submissions
Now showing items 1-20 of 27
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Immunoreactive proteins in Taenia solium/cysticercus cellulosae
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2016-03-17)Cysticercosis caused by Taenia solium is a common zoonotic parasitic disease in Latin America, Asia, Africa, and parts of Oceania, and it is responsible for many cases of epileptic seizures. Imaging techniques used to ... -
In vivo bioluminescence imaging in preclinical trials of genetic vaccines
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2015-05-22)DNA immunization is a rapidly developing vaccine platform for cancer, infectious disease, and allergies. The efficiency of DNA vaccination is largely determined by the efficiency of delivery and subsequent expression of ... -
Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2006-12-29)Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of ... -
Studies of innate immune stimulation with CpG in HIV infection
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2008-10-01)Two types of human immunodeficiency virus (HIV) may cause acquired immune deficiency syndrome (AIDS): HIV-1, the most pathogenic virus of the two and found worldwide, and HIV-2, which is mostly detected in West Africa and ... -
Total physical activity in middle-aged and elderly women from a population-based cohort
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2006-11-22)Regularly performed physical activity (PA) is associated with a reduced risk of coronary heart disease, stroke, type 2 diabetes, some forms of cancer, osteoporosis, and all-cause mortality. Due to its role in health promotion ... -
Molecular and cellular strategies to enhance efficacy of T cell-based cancer therapy
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2006-09-06)A combined approach of vaccination with β2-microglobulin (β2m)-deficient dendritic cells (DCs) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potent adjuvant may link cellular and molecular strategies ... -
The role of interferons in the resistance to infection with Chlamydia pneumoniae
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2006-05-25)Chlamydia pneumoniae is an obligate intracellular bacterial pathogen that infects the respiratory tract in human. IFN-gamma is an essential cytokine for the immune response triggered to limit infection with C. pneumoniae. ... -
Viral and host determinants in hepatitis B
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2006-05-26)The outcome of hepatitis B infection is highly variable, ranging from acute disease resulting in the elimination of infection to persistent infection that can lead to cirrhosis or hepatocellular carcinoma. The factors ... -
Coxsackie B virus pathogenesis in mice
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2006-05-18)Coxsackie B virus (CVB) belongs to the enterovirus (EV) genera of the Picornaviridae family. These infections range from asymptomatic, mild infections to serious diseases such as myocarditis, pancreatitis, paralysis, aseptic ... -
Induction of type I interferons and viral immunity
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2006-01-06)Virus-induced type I interferons (IFNα/β) are key mediators of innate immunity and important modulators of adaptive immunity. Early recognition of virus and induction of IFNα/β are important for limiting the spread of the ... -
Molecular epidemiology of hepatitis A, B and C in Estonia
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2006-03-31)During the last decade changes have occurred in the epidemiology of hepatitis A, B and C in Estonia. A shift from high to intermediate endemicity for HAV has led to a shift in age of susceptible individuals from children ... -
Immunotherapy in cancer and HIV
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2006-01-31)Two major threats to human health are cancer and human immunodeficiency virus (HIV) infection. In both cases, a feature of progress of the disease is a defective immune function. Immunological mechanisms have evolved whereby ... -
Epstein-Barr virus latency in transplant patients and healthy carriers
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2005-11-24)In this thesis, I studied the latency situation of Epstein-Barr virus (EBV) in bone marrow transplanted (BMT) patients and healthy virus carriers. Paper 1: Epstein-Barr virus genomes are found predominantly in ... -
Vaccination against drug-resistant HIV
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2005-11-24)As the use of antiretroviral drug treatment increases worldwide, development of drug resistant HIV phenotypes is expected to increase. The frequency of drug- or multi-drug resistant virus transmitted in primary infections ... -
Modulation of the deubiquitnating system during lymphoid cell activation and viral infection
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2005-08-15)The family of ubiquitin-specific proteases (USPs) removes ubiquitin from its conjugates and regulates the production and recycling of ubiquitin. USPs are thereby critically involved in the control of important functions ... -
Immune responses against Mycobacterium tuberculosis targets associated to latent and active tuberculosis infection
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2014-09-01)Background: Tuberculosis is a worldwide problem particularly in developing countries. Different clinical outcomes, such as the asymptomatic phase during infection or the symptomatic stage during active disease leads to ... -
Evaluation of the Rift Valley fever vaccination program in Mozambican cattle
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2013-09-26)Rift Valley fever (RVF) is a viral disease that is spread by various arthropods (primarily mosquitoes) and affects ruminants and humans. RVF has led to tremendous losses of livestock in many African countries, Saudi Arabia, ... -
Antiretroviral drug resistant HIV-1 in women and children living in Honduras
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2013-02-15)Antiretroviral therapy (ART) in HIV infected pregnant women contributes to the prevention of HIV transmission to the newborn. However, as ART can also induce HIV drug resistance during suboptimal levels of virological ... -
Molecular characterization of Mycobacterium tuberculosis isolates in Mozambique
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-27)Tuberculosis (TB) is one of the major health problems in Mozambique. It is estimated that 27,000 deaths caused by TB occur each year with an estimated incidence and prevalence rate of 431 and 504 per 100,000 population ... -
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology, 2008-10-03)Dengue fever (DF) is the most common global viral mosquito-borne infection, with 100 million estimated cases annually in tropical and subtropical areas. The dengue viruses (genus Flavivirus, Flaviviridae) occur in 4 serotypes ...