Pulmonary resection for malignant tumors
Author: Al-Ameri, Mamdoh
Date: 2018-06-08
Location: Nanna Svartz (J3:12) Eugeniav 3/Solnav 30, (Nya) Karolinska Universitetssjukhuset
Time: 09.00
Department: Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery
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Thesis (2.737Mb)
Abstract
Resection of malignant tumors in the lung represents greater than 70% of thoracic surgeries. The continuous evolution of new surgical techniques and management of malignant diseases have improved the clinical outcomes of survival and quality of life. The aim of this thesis is to review important clinical aspects of the surgical resection of malignant tumors in the lung.
Study I A prospective population-based cohort assessment of the relation between preoperative baseline self-reported SF-36 questionnaire data and long-term survival after thoracic procedures. The study included 249 patients planned for thoracic surgery at Karolinska University Hospital, Stockholm, Sweden, between 2006 and 2008. During an 8.0-year (median) follow-up, 48% of patients died. Patients with a physical component summary score less than the reference experienced significantly higher mortality rates compared with those of patients with lower mental component summary scores (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.34–3.06, p = 0.001) and (HR, 1.32; 95% CI, 0.84–3.06, p = 0.233), respectively.
Study II A population-based cohort study of 184 patients who underwent pulmonary metastasectomy for colorectal cancer at Karolinska University Hospital between January 1, 2004, and December 31, 2015. The median follow-up was 3.2 years, and 36% (66/184) of patients died. Five-year overall survival was 60% (95% CI, 50%–68%), and carcinoembryonic antigen levels were the only statistically significant prognostic factor of mortality (age- and sex-adjusted, [HR, 2.46; 95% CI, 1.15–5.26, p = 0.020]).
Study III A nationwide cohort study to investigate overall survival after surgical resection of pulmonary metastases of colorectal cancer in Sweden and to assess the discriminatory power of a recently suggested risk-prediction model. This study, which used the Swedish national quality register for thoracic surgery (ThoR), included 756 patients who underwent surgery between 2009 and 2015. Five-year overall survival was 56%, and the median follow-up was 2.9 years.
Study IV Evaluation of early and late clinical outcomes after video-assisted thoracic surgery (VATS) and thoracotomy-lobectomy for non-small cell lung cancer of a cohort of patients in Sweden. The study used the ThoR register and included patients (n = 285) who underwent VATS lobectomy at Karolinska University Hospital and patients (n = 1316) who underwent thoracotomy lobectomy at other hospitals in Sweden between 2012 and 2015.
Study V A study of a nationwide cohort conducted in Sweden to determine if the weekday of surgery influenced the long-term survival of patients listed in the ThoR register who underwent surgery for lung cancer between 2009 and 2015.
Study I A prospective population-based cohort assessment of the relation between preoperative baseline self-reported SF-36 questionnaire data and long-term survival after thoracic procedures. The study included 249 patients planned for thoracic surgery at Karolinska University Hospital, Stockholm, Sweden, between 2006 and 2008. During an 8.0-year (median) follow-up, 48% of patients died. Patients with a physical component summary score less than the reference experienced significantly higher mortality rates compared with those of patients with lower mental component summary scores (hazard ratio [HR], 2.02; 95% confidence interval [CI], 1.34–3.06, p = 0.001) and (HR, 1.32; 95% CI, 0.84–3.06, p = 0.233), respectively.
Study II A population-based cohort study of 184 patients who underwent pulmonary metastasectomy for colorectal cancer at Karolinska University Hospital between January 1, 2004, and December 31, 2015. The median follow-up was 3.2 years, and 36% (66/184) of patients died. Five-year overall survival was 60% (95% CI, 50%–68%), and carcinoembryonic antigen levels were the only statistically significant prognostic factor of mortality (age- and sex-adjusted, [HR, 2.46; 95% CI, 1.15–5.26, p = 0.020]).
Study III A nationwide cohort study to investigate overall survival after surgical resection of pulmonary metastases of colorectal cancer in Sweden and to assess the discriminatory power of a recently suggested risk-prediction model. This study, which used the Swedish national quality register for thoracic surgery (ThoR), included 756 patients who underwent surgery between 2009 and 2015. Five-year overall survival was 56%, and the median follow-up was 2.9 years.
Study IV Evaluation of early and late clinical outcomes after video-assisted thoracic surgery (VATS) and thoracotomy-lobectomy for non-small cell lung cancer of a cohort of patients in Sweden. The study used the ThoR register and included patients (n = 285) who underwent VATS lobectomy at Karolinska University Hospital and patients (n = 1316) who underwent thoracotomy lobectomy at other hospitals in Sweden between 2012 and 2015.
Study V A study of a nationwide cohort conducted in Sweden to determine if the weekday of surgery influenced the long-term survival of patients listed in the ThoR register who underwent surgery for lung cancer between 2009 and 2015.
List of papers:
I. Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Self-reported physical quality of life before thoracic operations is associated with long-term survival. Ann Thorac Surg. 2017;103:484-490.
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II. Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Long-term survival after surgery for pulmonary metastases from colorectal cancer: an observational cohort study. J Thorac Dis. 2017;9:4358-4365.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Surgery for pulmonary metastases from colorectal cancer: survival and prognostic factors. [Submitted]
IV. Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. [Submitted]
V. Jackson V, Al-Ameri M, Sartipy U. Weekday and survival after pulmonary resections for lung cancer: a Swedish nationwide cohort study. [Submitted]
I. Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Self-reported physical quality of life before thoracic operations is associated with long-term survival. Ann Thorac Surg. 2017;103:484-490.
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Long-term survival after surgery for pulmonary metastases from colorectal cancer: an observational cohort study. J Thorac Dis. 2017;9:4358-4365.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. Al-Ameri M, Persson M, Bergman P, Franco-Cereceda A, Sartipy U. Surgery for pulmonary metastases from colorectal cancer: survival and prognostic factors. [Submitted]
IV. Al-Ameri M, Bergman P, Franco-Cereceda A, Sartipy U. Video-assisted thoracoscopic versus open thoracotomy lobectomy: a Swedish nationwide cohort study. [Submitted]
V. Jackson V, Al-Ameri M, Sartipy U. Weekday and survival after pulmonary resections for lung cancer: a Swedish nationwide cohort study. [Submitted]
Institution: Karolinska Institutet
Supervisor: Sartipy, Ulrik
Co-supervisor: Franco-Cereceda, Anders
Issue date: 2018-05-09
Rights:
Publication year: 2018
ISBN: 978-91-7831-040-1
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