Doktorsavhandlingar / Doctoral Theses - SwePub
Recent submissions
-
Using the force : targeting p60AmotL2-mediated invasion in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-28)Mechanotransduction is the process by which cells convert mechanical forces into biochemical signals—and vice versa—thanks to a coordinated cascade of effects regulated by mechanomodulatory and cytoskeletal complexes. ... -
Improvement of microbiological diagnostics in sepsis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-03-27)Sepsis, a life-threatening condition characterized by a dysregulated host response to infection, poses significant diagnostic and therapeutic challenges, contributing to high morbidity and mortality rates worldwide. The ... -
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-27)Renal cell carcinoma (RCC) represents a significant clinical challenge due to its resistance to conventional therapies and its complex tumor microenvironment (TME). RCC's immunogenic nature, characterized by the infiltration ... -
Heart failure with preserved and reduced ejection fraction : comorbidities, therapies and cause-specific outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-27)Background: Heart failure (HF) is associated with worse prognosis and poor quality of life, and its rising global prevalence puts a growing strain on healthcare systems. While most previous studies have focused on ... -
Pharmacovigilance of mass drug administration as preventive chemotherapy to control and eliminate lymphatic filariasis in Tanzania
(Inst för global folkhälsa / Dept of Global Public Health, 2024-03-27)Mass drug administration (MDA) campaigns are usually conducted on an annual basis by many countries globally where neglected tropical diseases (NTDs), including lymphatic filariasis (LF), are endemic. Such campaigns are ... -
Noninvasive estimation of intracranial pressure with optic nerve sheath diameter sonography
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-26)Background: Modern neurointensive care aims to prevent or mitigate secondary cerebral insults after severe primary cerebral insults, such as subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI). Optimization of ... -
From preschool wheeze to childhood asthma : the role of genetics and environmental factors
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-26)Background: Respiratory illness with wheeze is very common at preschool age and is often the first clinical manifestation of asthma. Two-thirds of preschool wheezers outgrow their symptoms by their sixth birthday whereas ... -
The role of oxysterols in neurodegeneration : implications for cognitive function, maternal effects, and sex-specific differences
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-03-26)It is widely proven that an imbalance of cholesterol homeostasis within the brain is linked to several neurodegenerative diseases and in particular, Alzheimer's disease (AD). The brain, an organ highly enriched with ... -
Renal Doppler resistive index : applications in perioperative and critical care
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)Doppler-derived renal resistive index (RRI) has emerged as a promising bedside tool for assessing renal hemodynamics, and elevated values ≥0.70 have been associated with adverse outcomes in various clinical settings. This ... -
Single-cell analysis on specification of mammalian germline and its role in health and diseases
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-03-25)Germ cell specification is the first step for developing reproductive cells. The specification requires formative pluripotent stem cells as precursors. Previous attempts to capture formative pluripotency used opposite ... -
Meeting the needs of women : provision of long-acting reversible contraception at the time of abortion
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-03-25)Background and aim Unintended pregnancies represent a notable public health challenge, imposing substantial social and financial burdens on a global scale. In Sweden, approximately 37,000 abortions are conducted ... -
Temporal response to bioenergetic stress in adipose tissue and skeletal muscle
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-22)Diabetes is a common disease—affecting more than 500 million people. Although type 2 diabetes maintains a genetic component—the implementation of lifestyle modification serves as a potent risk-reducing modality. Chronic ... -
Development and function of GABAergic neurons in health and in a predisposition model of schizophrenia
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-03-21)In this thesis, I present four studies which examine i) the role of transcript factor Sox6 in the development and maintenance of cortical Sst interneurons, ii) the involvement of cortical neurogliaform cells (NGFCs) in the ... -
Automated external defibrillator-equipped drones for facilitating early defibrillation in out-of-hospital cardiac arrest
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-20)Background: Each year, approximately 3.8 million out-of-hospital cardiac arrests (OHCAs) occur globally. Survival rates are low (8–12%) and have not increased during the past decade. It is known that early cardiopulmonary ... -
Pediatric eosinophilic esophagitis
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-19)Background and aims: Eosinophilic Esophagitis (EoE) is an immune-mediated antigentriggered inflammatory disease, strictly located to the esophagus. The pathogenesis is still partly unknown, and there is a lack of biomarkers ... -
Family planning service – addressing potential barriers
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)Background: Access to family planning service is crucial for reproductive health. Family planning service include contraceptive methods as well as safe methods for pregnancy termination when needed. It was estimated in ... -
Genetic and epigenetic risk factors for asthma in infancy and childhood
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-03-18)Asthma is among the most common non-communicable diseases, with an increasing prevalence worldwide. The pathophysiology behind the disease is heterogeneous, including risk factors like genes, sex, allergies, virus infections, ... -
Diabetes, cardiovascular events, and lifestyle : from epidemiology to clinic
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-15)Today, the health care system plays an important role in the prevention of diseases, not least through support of a healthy lifestyle, including being physically active. Given the development of digital tools together with ... -
Translational studies of glucocerebrosidase in Parkinson´s disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-03-14)A number of genetic variants have been linked to Parkinson’s disease (PD). Among these, mutations in the GBA1 gene are identified as one of the most common risk factors for developing PD. The connection between increased ... -
Benefit-harm assessment in childbirth care, with breech presentation as an illustration
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-11)Introduction: Childbirth care is aiming at safe births and positive birth experience. Obstetric decision-making is often complicated. Breech presentation is an example of such complexity. Judgements about individual cases ...