Doktorsavhandlingar / Doctoral Theses - K1 (MMK)
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Recent submissions
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Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Surgical treatment of lung cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-02)Background: Surgery is a central part in the treatment of lung cancer. There have been recent advances in minimal invasive and lung sparing surgical techniques, but evidence regarding safety and implementability is not ... -
Neuromuscular electrical stimulation in physical inactivity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-30)Physical inactivity and immobilization have emerged as major health issues. Neuromuscular electrical stimulation (NMES) is a potential treatment to prevent the negative effects of physical inactivity, such as muscle atrophy ... -
Genetic studies of rare skeletal disorders : to solve the unsolved
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-03)Congenital skeletal disorders, also called skeletal dysplasias, constitute a diverse group of rare genetic conditions that occur in approximately 1 per 3000-5000 births. Skeletal dysplasias exhibit both clinical and molecular ... -
Temporal response to bioenergetic stress in adipose tissue and skeletal muscle
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-22)Diabetes is a common disease—affecting more than 500 million people. Although type 2 diabetes maintains a genetic component—the implementation of lifestyle modification serves as a potent risk-reducing modality. Chronic ... -
The role of thyroid hormone function and prokineticin-1 in pregnancy and offspring outcome in women with polycystic ovary syndrome
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-03-06)Thyroid disorders are common in women with polycystic ovary syndrome (PCOS) and both conditions are associated with adverse pregnancy outcomes, such as intrauterine growth restriction, preterm delivery, and gestational ... -
Exploring the gut microbiome in ADHD and schizophrenia spectrum disorder
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Emerging research indicates a complex relationship between the gut bacterial microbiome and psychiatric disorders, though findings are not always consistent. The gut-brain axis, involving gut microbiota, plays a crucial ... -
Cardiovascular magnetic resonance imaging of myocardium and pulmonary arterial pressure
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-28)Heart failure (HF) is a clinical syndrome characterized by high morbidity and mortality. HF can be associated with alteration in myocardial tissue composition such as focal myocardial fibrosis, also referred to as scarring, ... -
The efficacy of continuous peripheral blocks after cardiothoracic surgery as evaluated by opioid use, pain, and recovery
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-02-09)Pain after cardiothoracic surgery is most intense the first postoperative days and for the most part mild to moderate. International guidelines recommend a multimodal analgesic strategy that includes local anesthetics for ... -
Cardiovascular magnetic resonance evaluation of effusive and constrictive physiologies
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-31)This thesis presents an exploration of cardiovascular magnetic resonance (CMR) in the evaluation of effusive and constrictive heart conditions. Central to the thesis is advanced CMR as a diagnostic tool in pericardial ... -
Apolipoprotein CIII in the pathophysiology of diabetes mellitus
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-24)It has previously been shown that high levels of apolipoprotein CIII (apoCIII) are related to both type-1 (T1D) and type-2 diabetes (T2D). In this thesis, mechanisms whereby apoCIII affects diet- and genetically-induced ... -
Prostate cancer : investigating diagnosis, treatment and outcomes
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-01-19)Background: Prostate cancer is difficult to study. The prostate is located so that it is hard to palpate and because of the dense pelvic bones it is hard to visualize using radiology such as computed tomography. The prostate ... -
The bicuspid aortic valve and thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-14)About 1% of the population is born with an aortic valve composed of only two cusps, called a bicuspid aortic valve. Bicuspid aortic valve is associated with a high risk of both aortic valve disease and ascending aortic ... -
Studies on the acute porphyrias : with special reference to women’s health
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-11-01)The acute porphyrias are a group of rare inherited disorders of the metabolism of heme. Three acute porphyrias comprise most of the cases: acute intermittent porphyria (AIP), hereditary coproporphyria (HCP) and variegate ... -
Central nervous system malformations and epilepsy in children : genetic, imaging, and clinical aspects
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-31)Malformations of cortical development frequently lead to neurodevelopmental disabilities and epilepsy in children. Nevertheless, comprehensive prevalence data based on population studies are scarce. The objective of this ... -
The role of T-type calcium channels in human pancreatic β cell maturity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-27)This PhD work has optimized a series of in vivo, ex vivo and in vitro approaches to recapitulate, intervene and appraise in vivo maturation of naïve β cells within human induced pluripotent stem cell-derived islets ... -
Complex genomic rearrangements in rare brain disorders : genetic architecture and molecular consequences
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-23)Structural variants (SVs) within the genome, such as deletions, duplications, inversions, and translocations, are common but underappreciated causes of rare diseases. Complex genomic rearrangements involving two or more ... -
Severe COVID-19 and routine biomarker patterns
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-10-10)In acute infectious diseases, the composition of the blood changes. That includes proteins, blood cells and smaller solutes. Routine blood tests have a fundamental role in the diagnosis and follow-up of patients with ... -
Cardiovascular disease and health anxiety in patients with differentiated thyroid cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2023-09-22)Background Differentiated thyroid cancer (DTC) accounts for over 90% of all thyroid malignancies, and is typically treated with a total thyroidectomy and radioactive iodine (RAI) to eliminate both macro- and microscopic ...