Avhandlingar / Theses
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Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ... -
Infections, antibiotics, tobacco, genetic factors and risk of lada : latent autoimmune diabetes in adults, and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-17)Diabetes is a spectrum of chronic diseases characterized by hyperglycaemia. The aetiology and pathogenesis differ between types of diabetes, but all can lead to severe complications. Latent autoimmune diabetes in adults ... -
Immediate skin-to-skin contact after a very preterm birth : supporting the parent-infant relationship
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-16)Background: Preterm birth poses challenges that may negatively affect parental mental health and infant development. A well-functioning parent-infant relationship can mitigate the risk of preterm birth on infant development, ... -
Novel diagnostic and prognostic tools in infiltrative cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-16)Background: Heart failure is a severe medical condition, increasingly common in the aging population, causing both vast morbidity and mortality. Amongst different etiologies of heart failure, infiltrative cardiomyopathies ... -
Understanding the roles of avidity in biological systems
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-04-11)Understanding avidity is essential for elucidating complex molecular interactions and designing effective therapeutic strategies. This thesis aims to explore strategies and tools to understand how avidity influences ... -
Cancer risk, autoimmune comorbidity and autoantibodies in primary sclerosing cholangitis
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-05)Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease affecting the bile ducts primarily, and the liver parenchyma secondarily. The disease is progressive but highly variable between diseased. Some ... -
Sexual and reproductive health and rights among newly arrived migrants in Sweden : knowledge gaps and healthcare challenges
(Inst för global folkhälsa / Dept of Global Public Health, 2024-04-04)Introduction: Migration is one of today’s most pressing issues, especially concerning sexual and reproductive health and rights (SRHR) and human rights. Migrants may face heightened health vulnerabilities due to challenges ... -
Lineage, cell state and cell identity in the developing human brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-04)Organisms are complex systems consisting of thousands of distinct types of cells that perform a wide array of functions, yet for the most part share the same DNA. To regulate the expression of genes, the genome contains a ... -
Oral graft versus host disease : salivary gland pathology and tissue modelling
(Inst för odontologi / Dept of Dental Medicine, 2024-04-04)Chronic Graft versus Host Disease (cGVHD) is a consequence of dysregulated immune reconstitution after allogenic hematopoietic cell transplantation (alloHCT), a treatment for high-risk blood malignancies or immune ... -
From vaccination to infection : mechanistic studies of immune responses to SARS-CoV-2
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-04)The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 elevated population-level immunity and reduced ... -
In search of therapeutic candidates for tandem repeat disorders
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-04-04)Triplet-repeat disorders, including Friedreich's Ataxia (FRDA) and Huntington's disease (HD), are genetic conditions characterized by the expansion of specific trinucleotide sequences within affected genes. In FRDA, the ... -
Physiological and lifestyle-related cardiovascular risk factors for vessels, ventricle, and valve
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-03)Cardiovascular diseases are the most common cause of mortality globally, claiming twice as many lives as cancer and more than all nutritional disorders, infectious diseases, and maternal/neonatal conditions combined. The ... -
Genetic studies of rare skeletal disorders : to solve the unsolved
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-03)Congenital skeletal disorders, also called skeletal dysplasias, constitute a diverse group of rare genetic conditions that occur in approximately 1 per 3000-5000 births. Skeletal dysplasias exhibit both clinical and molecular ... -
The role of inflammatory cells in sarcoidosis and asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-02)Immuno-homeostasis refers to maintaining a delicate balance between immune responses and tolerance. It relies on the harmonious interplay of various inflammatory cells, including macrophages, monocytes, dendritic cells, T ... -
Supportive resources for self-care and informal care : uncovering the role of patient-driven innovations
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-04-02)Background: Persons living with long-term conditions and informal caregivers are often dependent on support for their self-care and informal care. The experience of insufficient support may lead some to develop health ... -
Life changing moments : transitions and critical points in young-onset dementia
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-04-02)Background: Persons who are diagnosed with dementia before the age of 65 are commonly referred to as persons with young-onset dementia (YOD). Younger persons and their families have different needs from those in older ... -
Using the force : targeting p60AmotL2-mediated invasion in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-28)Mechanotransduction is the process by which cells convert mechanical forces into biochemical signals—and vice versa—thanks to a coordinated cascade of effects regulated by mechanomodulatory and cytoskeletal complexes. These ... -
Improvement of microbiological diagnostics in sepsis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2024-03-27)Sepsis, a life-threatening condition characterized by a dysregulated host response to infection, poses significant diagnostic and therapeutic challenges, contributing to high morbidity and mortality rates worldwide. The ... -
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-03-27)Renal cell carcinoma (RCC) represents a significant clinical challenge due to its resistance to conventional therapies and its complex tumor microenvironment (TME). RCC's immunogenic nature, characterized by the infiltration ...