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Recent submissions

  • A DNA-nanoassembly-based approach to map membrane protein nanoenvironments 

    Ambrosetti, Elena; Bernardinelli, Giulio; Hoffecker, Ian; Hartmanis, Leonard; Kiriako, Georges; de Marco, Ario; Sandberg, Rickard; Högberg, Björn; Teixeira, Ana I. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)
    Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ...
  • Effects of design choices on the stiffness of wireframe DNA origami structures 

    Benson, Erik; Mohammed, Abdulmelik; Rayneau-Kirkhope, Daniel; Gådin, Andreas; Orponen, Pekka; Högberg, Björn (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24)
  • Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater 

    Claesson, Magnus; Siitonen, Vilja; Dobritzsch, Doreen; Metsä-Ketelä, Mikko; Schneider, Gunter (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-03-24)
    The glycosyltransferase SnogD from Streptomyces nogalater transfers a nogalamine moiety to the metabolic intermediate 3′,4′-demethoxynogalose-1-hydroxynogalamycinone during the final steps of biosynthesis of the aromatic ...
  • Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase 

    Johansson, Ann-Louise; Collins, Ruairi; Arnér, Elias S. J.; Brzezinski, Peter; Högbom, Martin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)
    Selenium is an essential trace element incorporated into selenoproteins as selenocysteine. Selenocysteine (Sec) lyases (SCLs) and cysteine (Cys) desulfurases (CDs) catalyze the removal of selenium or sulfur from Sec or ...
  • Redox pioneer: Professor Arne Holmgren 

    Arnér, Elias S. J. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)
    Dr. Arne Holmgren (Ph.D., 1968) is recognized here as a redox pioneer, because he has published at least one article on redox biology that has been cited over 1000 times and has published at least 10 articles, each cited ...
  • Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury 

    Locy, Morgan L.; Rogers, Lynette K.; Justin R., Prigge; Schmidt, Edward E.; Arnér, Elias S. J.; Tipple, Trent E. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)
    Aims: Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans.We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in ...
  • Biochemical Discrimination between Selenium and Sulfur 1: A Single Residue Provides Selenium Specificity to Human Selenocysteine Lyase 

    Collins, Ruairi; Johansson, Ann-Louise; Karlberg, Tobias; Markova, Natalia; van den Berg, Susanne; Olesen, Kenneth; Hammarström, Martin; Flores, Alex; Schüler, Herwig; Holmberg Schiavone, Lovisa; Brzezinski, Peter; Arnér, Elias S. J.; Högbom, Martin (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)
    Selenium and sulfur are two closely related basic elements utilized in nature for a vast array of biochemical reactions. While toxic at higher concentrations, selenium is an essential trace element incorporated into ...
  • Combining [(11)C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts 

    Cheng, Q; Lu, L; Grafström, J; Olofsson, MH; Thorell, JO; Samén, E; Johansson, K; Ahlzén, HS; Stone-Elander, S; Linder, S; Arnér, Elias S. J. (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsSel-tag Imaging Project, 2012-10-02)
    BACKGROUND: In vivo imaging using Annexin A5-based radioligands is a powerful technique for visualizing massive cell death, but has been less successful in monitoring the modest cell death typically seen in solid tumors ...
  • HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically 11C-Labeled Sel-Tagged Affibody Molecule 

    Wållberg, H; Grafström, J; Cheng, Q; Lu, L; Martinsson Ahlzén, HS; Samén, E; Thorell, JO; Johansson, K; Dunås, F; Olofsson, MH; Stone-Elander, S; Arnér, Elias S. J.; Ståhl, S (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-02)
    A rapid, reliable method for distinguishing tumors or metastases that overexpress human epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for individualizing therapy and predicting prognoses. ...