Artiklar / Articles - K7 (OnkPat)
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Recent submissions
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-08-19)Oxidative DNA damage is recognised by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1), initiating repair. Here, we describe a small molecule ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Breast cancer genetic risk profile is differentially associated with interval and screen-detected breast cancers
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)Background: Polygenic risk profiles computed from multiple common susceptibility alleles for breast cancer have been shown to identify women at different levels of breast cancer risk. We evaluated whether this genetic risk ... -
Assessment of breast cancer risk factors reveals subtype heterogeneity
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)Subtype heterogeneity for breast cancer risk factors has been suspected, potentially reflecting etiological differences and implicating risk prediction. Reports are conflicting regarding presence of heterogeneity for many ... -
Time from breast cancer diagnosis to therapeutic surgery and breast cancer prognosis : a population-based cohort study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-04-17)Theoretically, time from breast cancer diagnosis to therapeutic surgery should affect survival. However, it is unclear whether this holds true in a modern healthcare setting in which breast cancer surgery is carried out ... -
Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-24)Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and ... -
A framework for organ dose estimation in x-ray angiography and interventional radiology based on dose-related data in DICOM structured reports
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-03-07)Although interventional x-ray angiography (XA) procedures involve relatively high radiation doses that can lead to deterministic tissue reactions in addition to stochastic effects, convenient and accurate estimation of ... -
Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between ... -
Exome sequencing of contralateral breast cancer identifies metastatic disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-05)Women with contralateral breast cancer (CBC) have significantly worse prognosis compared to women with unilateral cancer. A possible explanation of the poor prognosis of patients with CBC is that in a subset of patients, ... -
Risk of hospitalization and death due to bone fractures after breast cancer: a registry-based cohort study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-12-01)BACKGROUND: Bone fractures may have an impact on prognosis of breast cancer. The long-term risks of bone fracture in breast cancer patients have not been thoroughly studied. METHODS: Poisson regression was used to ... -
Time-dependent risk and predictors of venous thromboembolism in breast cancer patients: a population-based cohort study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-11-29)BACKGROUND: Venous thromboembolism (VTE) is a serious complication of cancer and its treatment. The current study assessed the risk and clinical predictors of VTE in breast cancer patients by time since diagnosis. METHODS: ... -
Infection-related hospitalizations in breast cancer patients : risk and impact on prognosis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-11-29)OBJECTIVES: Infections are a common cause of hospitalization in breast cancer patients. We studied the risk, clinical characteristics and outcomes of infection-related hospitalizations in this patient population. METHODS: ... -
Targeting non-receptor tyrosine kinases using small molecule inhibitors : an overview of recent advances
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-28)Protein tyrosine kinases are enzymes that catalyze the transfer of phosphate groups from ATP to tyrosine residues on other proteins as substrate. Phosphorylation at tyrosine residues regulates several functions, including ... -
Ibrutinib-A double-edge sword in cancer and autoimmune disorders
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-28)Targeted therapies have appeared as new treatment options for several disease types, including cancer and autoimmune disorders. Of several targets, tyrosine kinases (TKs) are among the most promising. Overexpression of TKs ... -
Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-28)The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. ... -
Targeting receptor tyrosine kinases using monoclonal antibodies : the most specific tools for targeted-based cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-23)Receptor tyrosine kinases (RTKs) family is comprised of different cell surface glycoproteins. These enzymes participate and regulate vital processes such as cell proliferation, polarity, differentiation, cell to cell ... -
Spontaneous immunity against the receptor tyrosine kinase ROR1 in patients with chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-12-23)Background: ROR1 is a receptor tyrosine kinase expressed in chronic lymphocytic leukemia (CLL) and several other malignancies but absent in most adult normal tissues. ROR1 is considered an onco-fetal antigen. In the present ... -
The skewed balance between regulatory T cells and Th17 in chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-05-19)While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many ... -
The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-04-23) -
Novel and emerging targeted-based cancer therapy agents and methods
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2015-02-09)After several decades of uncovering the cancer features and following the improvement of therapeutic agents; however cancer remains as one of the major reasons of mortality. Chemotherapy is one of the main treatment options ...