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  • Allergies to food and airborne allergens in children and adolescents : role of epigenetics in a changing environment 

    Melén, Erik; Koppelman, Gerard H; Vicedo-Cabrera, Ana Maria; Andersen, Zorana Jovanovic; Supinda, Bunyavanich (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-02-17)
    Allergic diseases today affect millions of children and adolescents worldwide. In this review, we focus on allergies to food and airborne allergens, and provide examples of prevalence trends during a time when climate ...
  • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age 

    Merid, Simon Kebede; Novoloaca, Alexei; Sharp, Gemma C; Küpers, Leanne K; Kho, Alvin T; Roy, Ritu; Gao, Lu; Annesi-Maesano, Isabella; Jain, Pooja; Plusquin, Michelle; Kogevinas, Manolis; Allard, Catherine; Vehmeijer, Florianne O; Kazmi, Nabila; Salas, Lucas A; Rezwan, Faisal I; Zhang, Hongmei; Sebert, Sylvain; Czamara, Darina; Rifas-Shiman, Sheryl L; Melton, Phillip E; Lawlor, Debbie A; Pershagen, Göran; Breton, Carrie V; Huen, Karen; Baiz, Nour; Gagliardi, Luigi; Nawrot, Tim S; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; Nohr, Ellen Aagaard; Bustamante, Mariona; Ewart, Susan L; Karmaus, Wilfried; Zhao, Shanshan; Page, Christian M; Herceg, Zdenko; Jarvelin, Marjo-Riitta; Lahti, Jari; Baccarelli, Andrea A; Anderson, Denise; Kachroo, Priyadarshini; Relton, Caroline L; Bergström, Anna; Eskenazi, Brenda; Soomro, Munawar Hussain; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; Jaddoe, Vincent W; Sørensen, Thorkild I A; Vrijheid, Martine; Arshad, S Hasan; Holloway, John W; Håberg, Siri E; Magnus, Per; Dwyer, Terence; Binder, Elisabeth B; DeMeo, Dawn L; Vonk, Judith M; Newnham, John; Tantisira, Kelan G; Kull, Inger; Wiemels, Joseph L; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Munthe-Kaas, Monica C; Räikkönen, Katri; Oken, Emily; Huang, Rae-Chi; Weiss, Scott T; Antó, Josep Maria; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catarina; Cardenas, Andres; Gruzieva, Olena; Xu, Cheng-Jian; Reese, Sarah E; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matthias; Holland, Nina; Ghantous, Akram; Hivert, Marie-France; Felix, Janine F; Koppelman, Gerard H; London, Stephanie J; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure 

    Merid, Simon Kebede; Bustamante, Mariona; Standl, Marie; Sunyer, Jordi; Heinrich, Joachim; Lemonnier, Nathanaël; Aguilar, Daniel; Antó, Josep Maria; Bousquet, Jean; Santa-Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M; Koppelman, Gerard H; Melén, Erik; Gruzieva, Olena (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE 

    Wang, Gang; Hallberg, Jenny; Bergström, Petra Um; Janson, Christer; Pershagen, Göran; Gruzieva, Olena; van Hage, Marianne; Georgelis, Antonios; Bergström, Anna; Kull, Inger; Lindén, Anders; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)
    BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence and early life ...
  • Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma 

    Kere, Maura; Gruzieva, Olena; Ullemar, Vilhelmina; Söderhäll, Cilla; Greco, Dario; Kull, Inger; Bergström, Anna; Pershagen, Göran; Almqvist, Catarina; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-09-25)
  • Sibship and dispensing patterns of asthma medication in young children : a population based study 

    Dahlén, Elin; Lundholm, Cecilia; Wikström Jonsson, Eva; Kull, Inger; Wettermark, Björn; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Purpose: Our aim was to study the association between sibship and dispensing patterns of asthma medication in young children, focusing on incidence and persistence, and taking sibship status, asthma diagnoses, and siblings’ ...
  • Cesarean delivery, preterm birth and risk of food allergy : nationwide Swedish cohort study of over 1 million children 

    Mitselou, Niki; Hallberg, Jenny; Stephansson, Olof; Almqvist, Catarina; Melén, Erik; Ludvigsson, Jonas F (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)
    Background & Objectives: Little is known about early life risk factors for food allergy in children. We examined the association between perinatal characteristics and future risk of food allergy in offspring. Methods: ...
  • Allergen-specific IgE over time in women before, during and after pregnancy 

    Hedman, Anna M; Lundholm, Cecilia; Scheynius, Annika; Alm, Johan; Andolf, Annika; Pershagen, Göran; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)
    The trajectory of IgE levels before, during and after pregnancy in sensitized individuals is characterized by significant increase in specific IgE to birch allergens but not to other allergens after multiple testing. This ...
  • The influence of childhood asthma on puberty and height in Swedish adolescents 

    Protudjer, Jennifer; Lundholm, Cecilia; Bergström, Anna; Kull, Inger; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    BACKGROUND: Evidence relating to the effect of asthma on puberty or height is inconclusive. We aimed to examine whether the exposure of childhood asthma, including timing and phenotypes, and inhaled corticosteroid (ICS) ...
  • Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers 

    Rantalainen, Mattias; Klevebring, Daniel; Lindberg, Johan; Ivansson, Emma; Rosin, Gustaf; Kis, Lorand; Celebiouglu, Fuat; Fredriksson, Irma; Czene, Kamila; Frisell, Jan; Hartman, Johan; Bergh, Jonas; Grönberg, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-16)
    Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between ...
  • Asthma during pregnancy in a population-based study : pregnancy complications and adverse perinatal outcomes 

    Rejnö, Gustaf; Lundholm, Cecilia; Gong, Tong; Larsson, Kjell; Saltvedt, Sissel; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-01-02)
    BACKGROUND: Asthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to ...
  • An observational study on the outcome after surgery for lumbar disc herniation in adolescents compared to adults based on the Swedish Spine Register 

    Lagerbäck, Tobias; Elkan, Peter; Möller, Hans; Grauers, Anna; Diarbakerli, Elias; Gerdhem, Paul (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2015-08-05)
    BACKGROUND CONTEXT: Disc-related sciatica has a prevalence of about 2% in adults, but is rare in adolescents. If conservative treatment is unsuccessful, surgery is an option. PURPOSE: The aim of this study was to ...
  • Breastfeeding, asthma, and allergy : a tale of two cities 

    Brew, Bronwyn K; Kull, Inger; Garden, Frances L; Almqvist, Catarina; Bergström, Anna; Lind, Tomas; Webb, Karen L; Wickman, Magnus; Marks, Guy B (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2015-07-21)
    BACKGROUND: The effect of breastfeeding duration on subsequent asthma and allergy remains the subject of much controversy. OBJECTIVE: To investigate whether differences in study design or disease-related exposure ...
  • Obstetric brachial plexus injury : expectations before and satisfaction three months after secondary surgery on the shoulder 

    Westin, Britt; Hultgren, Tomas; Koch, Lena von (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2013-12-12)
    Introduction: Children affected by obstetrical brachial plexus injury frequently have residual external rotation weakness in the shoulder. Secondary surgical procedures are available for improvement. The aim of this study ...
  • Development and comorbidity of eczema, asthma and rhinitis to age 12 : data from the BAMSE birth cohort 

    Ballardini, Natalia; Kull, Inger; Lind, Tomas; Hallner, Eva; Almqvist, Catarina; Östblom, Eva; Melén, Erik; Pershagen, Göran; Lilja, Gunnar; Bergström, Anna; Wickman, Magnus (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2013-12-04)
    BACKGROUND: Allergy-related diseases are a public health issue, but knowledge on development and comorbidity among children is scarce. The aim was to study the development of eczema, asthma and rhinitis in relation to sex ...
  • Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk 

    Dunlop, Malcolm G; Dobbins, Sara E; Farrington, Susan M; Jones, Angela M; Palles, Claire; Whiffin, Nicola; Tenesa, Albert; Spain, Sarah; Broderick, Peter; Ooi, Li-Yin; Domingo, Enric; Smillie, Claire; Henrion, Marc; Frampton, Matthew; Martin, Lynn; Grimes, Graeme; Gorman, Maggie; Semple, Colin; Ma, Yusanne P; Barclay, Ella; Prendergast, James; Cazier, Jean-Baptiste; Olver, Bianca; Penegar, Steven; Lubbe, Steven; Chandler, Ian; Carvajal-Carmona, Luis G; Ballereau, Stephane; Lloyd, Amy; Vijayakrishnan, Jayaram; Zgaga, Lina; Rudan, Igor; Theodoratou, Evropi; Colorectal Tumour Gene Identification (CORGI) Consortium; Starr, John M; Deary, Ian; Kirac, Iva; Kovacevic, Dujo; Aaltonen, Lauri A; Renkonen-Sinisalo, Laura; Mecklin, Jukka-Pekka; Matsuda, Koichi; Nakamura, Yusuke; Okada, Yukinori; Gallinger, Steven; Duggan, David J; Conti, David; Newcomb, Polly A; Hopper, John L; Jenkins, Mark A; Schumacher, Fredrick; Casey, Graham; Easton, Douglas; Shah, Mitul; Pharoah, Paul; Lindblom, Annika; Liu, Tao; Swedish Low-Risk Colorectal Cancer Study Group; Smith, Christopher G; West, Hannah; Cheadle, Jeremy P; COIN Collaborative Group; Midgley, Rachel; Kerr, David J; Campbell, Harry; Tomlinson, Ian; Houlston, Richard S (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2013-02-07)
    We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in ...
  • Hospital incident command system (HICS) performance in Iran : decision making during disasters 

    Djalali, Ahmadreza; Castrén, Maaret; Hosseinijenab, Vahid; Khatib, Mahmoud; Ohlen, Gunnar; Kurland, Lisa (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2012-05-25)
    Background: Hospitals are cornerstones for health care in a community and must continue to function in the face of a disaster. The Hospital Incident Command System (HICS) is a method by which the hospital operates when an ...
  • A fundamental, national, medical disaster management plan : an education-based model 

    Djalali, Ahmadreza; Hosseinijenab, Vahid; Hasani, Azadeh; Shirmardi, Kianoush; Castrén, Maaret; Öhlén, Gunnar; Panahi, Farzad (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2012-05-25)
    During disasters, especially earthquakes, health systems are expected to play an essential role in reducing mortality and morbidity. The most significant naturally occurring disaster in Iran is earthquakes; they have killed ...
  • Facilitators and obstacles in pre-hospital medical response to earthquakes : a qualitative study 

    Djalali, Ahmadreza; Khankeh, Hamidreza; Öhlén, Gunnar; Castrén, Maaret; Kurland, Lisa (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2012-03-28)
    BACKGROUND: Earthquakes are renowned as being amongst the most dangerous and destructive types of natural disasters. Iran, a developing country in Asia, is prone to earthquakes and is ranked as one of the most vulnerable ...