Doktorsavhandlingar / Doctoral Theses - S1 (KI SÖS)
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Recent submissions
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Automated external defibrillator-equipped drones for facilitating early defibrillation in out-of-hospital cardiac arrest
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-20)Background: Each year, approximately 3.8 million out-of-hospital cardiac arrests (OHCAs) occur globally. Survival rates are low (8–12%) and have not increased during the past decade. It is known that early cardiopulmonary ... -
Pediatric eosinophilic esophagitis
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-19)Background and aims: Eosinophilic Esophagitis (EoE) is an immune-mediated antigentriggered inflammatory disease, strictly located to the esophagus. The pathogenesis is still partly unknown, and there is a lack of biomarkers ... -
Benefit-harm assessment in childbirth care, with breech presentation as an illustration
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-03-11)Introduction: Childbirth care is aiming at safe births and positive birth experience. Obstetric decision-making is often complicated. Breech presentation is an example of such complexity. Judgements about individual cases ... -
Severe poisonings in Sweden : demography, intensive care, and death
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)Background: Poisonings are common and diverse in their origins, clinical presentations, and outcomes. Poisoning accounts for a substantial number of hospital admissions with need for a higher level of care. The hospital ... -
Hemodynamic optimization in critically ill patients
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-02-23)Background: Intravenous fluids are one of the most common treatments in the health care setting and are usually given in response to hemodynamic instability or shock. However, this rests on the assumption that the cause ... -
On cardiovascular complications in people with type 2 diabetes : Aspects of incretin-based therapy and glycemic control
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-01-15)Background: Hyperglycemia, insulin resistance, and the presence of advanced glycation end products are key features of type 2 diabetes (T2DM) and the leading mechanisms behind the increased cardiovascular risk observed in ... -
Anterior cruciate ligament injuries : studies on the adverse events and long-term outcomes
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-12-15)The overall aims of this thesis were to identify the main adverse events after anterior cruciate ligament (ACL) injuries, to study the clinical presentation and the consequences of the adverse event (post-operative septic ... -
Distal radius fractures : a risk throughout life
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-11-06)Treating distal radius fractures (DRFs) is routine in most orthopedic clinics. Most fractures are treated non-operatively but, in some cases, surgery is needed to restore function. There are still controversies regarding ... -
The scaphoid : from fracture to fusion
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-11-02)In paper I, the incidence, treatment approaches, and rates of nonunion in scaphoid fractures were examined using data from 34,377 patients recorded in the Swedish National Patient Register (NPR) between 2006-2015. The ... -
Risks and risk monitoring in sotalol therapy for atrial fibrillation
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-10-26)Background: Atrial fibrillation (AF) stands as the most prevalent arrhythmia, significantly impacting both the prognosis and symptomatology of affected individuals. Healthcare expenditures associated with AF treatment and ... -
Colorectal surgery in Sweden and Ethiopia : stoma issues and covid-19 consequences
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-10-23)Creation and reversal of an ostomy are common procedures in colorectal surgery, and problems related to these surgeries are still in many aspects unsolved and affect people’s everyday life. Ostomy problems are closely ... -
CYP2D6-polymorphism and effect of adjuvant tamoxifen in breast cancer patients
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-09-04)Adjuvant tamoxifen at the standard dose of 20 mg daily for five to ten years reduces the risk for relapse and mortality in hormone sensitive breast cancer. The effect however varies and no early marker of poor response is ... -
Writing a bachelor's thesis in nursing education : a tool for the future
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-08-31)Writing a bachelor’s thesis is associated with the demonstration of generic, scientific, and transferable knowledge and skills in the main area of studies in their first cycle of higher education. The many goals are ... -
On stroke risk in type 2 diabetes : focus on glycemic control, insulin resistance, obesity and recovery
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-08-14)Background: People with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. In this thesis the focus is on stroke with different aspects of aims, e.g. the risk of stroke in people with T2D, the role of ... -
Emergency medical dispatching : protocols, experiences and priorities
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-05-04)Each year, millions of people call the emergency number with a wide variety of symptoms and various levels of illness severity. At its’ core, emergency medical dispatching encompasses the answering of these calls, the ... -
Treatment of coagulopathy in patients with critical COVID-19
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-04-20)Introduction: Thromboembolic complications affect a large proportion of patients with critical COVID-19, and it may be associated with an increased risk of death. It has been hypothesized that both the virus of SARS-CoV-2 ... -
Aspects of intensive care after cardiac arrest
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-03-31)Background: Cardiovascular disease, and in particular cardiac arrest with the subsequent associated brain injury, is the most common cause of death in many countries. Annually, around 6000 people suffer from Out-of-Hospital ... -
Early life exposures and lung function development
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-03-27)BACKGROUND: Lung development is a dynamic process, vulnerable to adverse environmental exposures. Starting in utero, development continues postnatally, and although lung structure is mainly set at around two years of age, ... -
Echocardiography in myocardial infarction : aspects on diastolic function and evaluation by cardiovascular magnetic resonance imaging
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2023-01-18)Background: Echocardiography is routinely used to evaluate patients with known or suspected myocardial infarction (MI). Cardiovascular magnetic resonance imaging (CMR) provides the ability to quantify myocardial infarction ... -
Treatment and consequences of atopic dermatitis from childhood to adulthood
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2022-11-14)Background: Atopic dermatitis (AD) is a common, itching, chronic disease from childhood up to adulthood, which requires daily treatment. The treatment goal is to achieve as the longest symptom-free periods possible. In ...