Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions

Now showing items 21-40 of 514

    • Radiotherapy in advanced head and neck cancer 

      Embring, Anna (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-03-17)
      Head and neck cancer (HNC) is a group of malignant tumours located in the mucosa of the upper aero-digestive tract. The location of the tumour, close to several critical organs, can often result in great suffering for the ...

    • Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy 

      Palomar Siles, Mireia (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-03-09)
      A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. Tumor suppressor ...

    • Prognostic and predictive factors for colorectal cancer 

      Karimi, Masoud (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2023-01-19)
      Colorectal cancer is the third most common cancer worldwide of which approximately 30% of cases are localized in the rectum. Rectal cancer accounts for around 700, 000 cases and 310, 000 deaths annually across the world ...

    • When the bear lost its tail : targeting the GRK/β-arrestins downstream IGF1R in non-epithelial malignancies 

      Cismas, Oana-Sonia (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-11-25)
      Plasma membrane receptors are highly specialized cell surface structures that receive extracellular information and process them into biological responses. Among them, this thesis focuses on two major receptor families: ...

    • Cancer proteogenomics : connecting genotype to molecular phenotype 

      Siavelis, Ioannis (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-11-24)
      The central dogma of molecular biology describes the one-way road from DNA to RNA and finally to protein. Yet, how this flow of information encoded in DNA as genes (genotype) is regulated in order to produce the observable ...

    • Long-term oncological outcome and health-related quality of life after curative treatment of prostate cancer with HDR-brachytherapy and external beam radiotherapy 

      Hjälm-Eriksson, Marie (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-10-24)
      Prostate cancer (PC) is a major health problem among men in the western world. The prognosis of PC varies, with high mortality rates for high-risk disease in contrast to a mild course in low risk cancers with almost no ...

    • Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer 

      Schoutrop, Esther (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-09-19)
      Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR ...

    • Beyond transcription : a post-transcriptional role of 3D chromatin crosstalk in oncogene regulation 

      Vestlund, Johanna (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-09-09)
      This thesis explores how stochastic chromatin fibre interactions, chromatin organization in the 3D nuclear architecture, and environmental signals collaborate to regulate MYC oncogene expression in human colon cancer cells. ...

    • Advanced machine learning methods for oncological image analysis 

      Astaraki, Mehdi (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-09-06)
      Cancer is a major public health problem, accounting for an estimated 10 million deaths worldwide in 2020 alone. Rapid advances in the field of image acquisition and hardware development over the past three decades have ...

    • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function 

      Michel, Maurice; Benitez-Buelga, Carlos; Calvo, Patricia A; Hanna, Bishoy M F; Mortusewicz, Oliver; Masuyer, Geoffrey; Davies, Jonathan; Wallner, Olov; Sanjiv, Kumar; Albers, Julian J; Castaneda-Zegarra, Sergio; Jemth, Ann-Sofie; Visnes, Torkild; Saste-Perona, Ana; Danda, Akhilesh N; Homan, Evert J; Marimuthu, Kartrick; Zhenjun, Zhao; Chi, Celestine N; Sarno, Antonio; Wiita, Elisee; von Nicolai, Catharina; Komor, Anna J; Rajagopal, Varshni; Müller, Sarah; Hank, Emily C; Varga, Marek; Scaletti, Emma R; Pandey, Monica; Karsten, Stella; Haslene-Hox, Hanne; Loevenich, Simon; Marttila, Petra; Rasti, Azita; Mamonov, Kirill; Ortis, Florian; Schömberg, Fritz; Loseva, Olga; Stewart, Josephine; D'Arcy-Evans, Nicholas; Koolmeister, Tobias; Henriksson, Martin; Michel, Dana; de Ory, Ana; Acero, Lucia; Calvete, Oriol; Scobie, Martin; Hertweck, Christian; Vilotijevic, Ivan; Kalderén, Christina; Osorio, Ana; Perona, Rosario; Stolz, Alexandra; Stenmark, Pal; Warpman Berglund, Ulrika; de Vega, Miguel; Helleday, Thomas (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-08-19)
      Oxidative DNA damage is recognised by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1), initiating repair. Here, we describe a small molecule ...

    • Morphologic and genetic features of sarcomas : improving diagnosis and exploring biomarkers 

      Zhang, Yifan (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-08-16)
      Sarcomas are malignant tumors of soft tissue and bone origin. They are a family of rare but diverse neoplasms which pose clinical challenges due to their heterogeneous properties. In order to increase our understanding of ...

    • Evaluation of genetic cancer predisposition and potential cancer genes 

      Liu, Yaxuan (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-05-30)
      Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer ...

    • Investigating the treatment of metastatic breast cancer : real-world evidence on treatment patterns, safety and efficacy 

      Edman Kessler, Luisa (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-05-25)
      Metastatic breast cancer is an incurable disease causing a spectrum of symptoms and leading to a continuous deterioration of performance status and quality of life. It is a heterogeneous disease, with survival being ...

    • Studies on human papillomavirus (HPV) and other markers in the development and prognosis of HPV associated cancer 

      Ährlund-Richter, Andreas (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-05-18)
      Background and aims: Human papilloma virus (HPV) is a risk factor for anogenital and oropharyngeal cancer (OPSCC) and commonly transmitted sexually although most infections are cleared without adverse effects. Notably, the ...

    • Morphological, immunohistochemical and genetic aspects of acinar and ductal adenocarcinoma of the prostate 

      Lindh, Claes (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-05-04)
      Prostate cancer is one of the most common causes of cancer-related death in developed countries. Acinar adenocarcinoma is by far the most common subtype of prostate cancer, with ductal adenocarcinoma being the second most ...

    • Current and possible future diagnostic methods for upper tract urothelial carcinoma 

      Grahn, Alexandra (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-04-27)
      Background: Urothelial carcinoma is a type of cancer originating from the mucus membrane of the urinary tract. It most commonly occurs in the bladder but may also occur in the upper urinary tract, then called UTUC. UTUC ...

    • Dissecting the roles of viral T-antigens in Merkel cell carcinoma 

      Gao, Jiwei (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-04-11)
      Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced ...

    • Upper-tract urothelial carcinoma : diagnostics and prognostic factors 

      Malm, Camilla (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-04-08)
      Upper-tract urothelial carcinoma (UTUC) is rare, constituting 5-10% of all urothelial cancers. Urothelial carcinoma of the bladder is a common disease and is more studied than UTUC. The incidence of UTUC is rising, with ...

    • Immunoregulatory properties of CD137-CD137 ligand axis in tumours and chronic inflammatory conditions 

      Khang, Luu Nguyen (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-03-11)
      CD137 (4-1BB/TNFRSF9) is a member of the TNF receptor superfamily. CD137 expression is activation-dependent, and usually reported on T cells and NK cells. Its natural ligand is CD137 ligand (CD137L), mainly found on ...

    • Development of radiometal-based labelling techniques and tracers for non-invasive molecular imaging 

      Jussing, Emma (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-03-03)
      Metallic radionuclides, radiometals, have an important role in nuclear medicine. Their straightforward coordination radiochemistry allows for a large variety of applications. The similarities and differences between the ...