Licentiatavhandlingar / Licentiate Theses - C2 (MBB)
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(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2008-11-05)Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints with a complex aetiology affected by largely unknown genetic and environmental factors. Because ~60% of susceptibility to RA is genetically inherited, ...
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2006-11-27)Leukotrienes (LT) are potent lipid mediators, synthesized from arachidonic acid (AA) upon cell activation. The essential enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), converting AA, through a two step process ...