Artiklar / Articles: Recent submissions

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    • Wearable neuromuscular electrical stimulation on quadriceps muscle can increase venous flow 

      Flodin, Johanna; Wallenius, Philip; Guo, Li; Persson, Nils-Krister; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase peak venous velocity ...

    • Residual substance P levels after capsaicin treatment correlate with tendon repair 

      Bring, Daniel K I; Paulson, Kent; Renstrom, Per; Salo, Paul; Hart, David A; Ackermann, Paul W (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      The aim of the study was to assess healing after capsaicin-induced SP depletion during rat Achilles tendon repair by biomechanical testing. Capsaicin treatment reduced the concentrations of substance P (SP) by ~60% ...

    • Prolonged immobilization compromises up-regulation of repair genes after tendon rupture in a rat model 

      Bring, D; Reno, C; Renstrom, P; Salo, P; Hart, D; Ackermann, P (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      It was hypothesized that mobilization versus immobilization after injury would promote tissue healing by regulating gene expression for molecules associated with repair. Cast immobilization versus free mobilization was ...

    • High plantar force loading after Achilles tendon rupture repair with early functional mobilization 

      Aufwerber, Susanna; Heijne, Annette; Grävare Silbernagel, Karin; Ackermann, Paul W; Ackermann, Paul (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      Background: Mechanical loading is essential for tendon healing and may explain variability in patient outcomes after Achilles tendon rupture (ATR) repair. However, there is no consensus regarding the optimal postoperative ...

    • Knee extensor force production and discomfort during neuromuscular electrical stimulation of quadriceps with and without gluteal muscle co-stimulation 

      Flodin, J; Mikkelsen, C; Ackermann, P W; Flodin, Johanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      Purpose: To investigate whether Neuromuscular Electrical Stimulation (NMES) simultaneously applied on the quadriceps (Q) and gluteal (G) muscles, as compared to single Q-stimulation alters the knee extensor force production ...

    • The effect of neuromuscular electrical stimulation on the human skeletal muscle transcriptome 

      Flodin, Johanna; Reitzner, Stefan M; Emanuelsson, Eric B; Sundberg, Carl Johan; Ackermann, Paul; Flodin, Johanna (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-03)
      Aim: The influence on acute skeletal muscle transcriptomics of neuromuscular electrical stimulation (NMES), as compared to established exercises, is poorly understood. We aimed to investigate the effects on global ...

    • Protein intake and healthy aging : sooner rather than later? 

      Carballo-Casla, Adrián; Ortolá, Rosario; Calderón-Larrañaga, Amaia (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-03-05)

    • Standardization of antigen-emulsion preparations for the induction of autoimmune disease models 

      Topping, Louise M; Romero-Castillo, Laura; Urbonaviciute, Vilma; Bolinsson, Hans; Clanchy, Felix I; Holmdahl, Rikard; Bäckström, B Thomas; Williams, Richard O (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-09)
      Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models, and the ...

    • Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice 

      Aoun, Mike; Coelho, Ana; Krämer, Alexander; Saxena, Amit; Sabatier, Pierre; Beusch, Christian Michel; Lönnblom, Erik; Geng, Manman; Do, Nhu-Nguyen; Xu, Zhongwei; Zhang, Jingdian; He, Yibo; Romero Castillo, Laura; Abolhassani, Hassan; Xu, Bingze; Viljanen, Johan; Rorbach, Joanna; Fernandez Lahore, Gonzalo; Gjertsson, Inger; Kastbom, Alf; Sjöwall, Christopher; Kihlberg, Jan; Zubarev, Roman A; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
      B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, ...

    • Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis 

      Urbonaviciute, Vilma; Romero-Castillo, Laura; Xu, Bingze; Luo, Huqiao; Schneider, Nadine; Weisse, Sylvia; Do, Nhu-Nguyen; Oliveira-Coelho, Ana; Fernandez Lahore, Gonzalo; Li, Taotao; Sabatier, Pierre; Beusch, Christian M; Viljanen, Johan; Zubarev, Roman A; Kihlberg, Jan; Bäcklund, Johan; Burkhardt, Harald; Holmdahl, Rikard (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)
      A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we ...

    • Being prevented from providing good care : a conceptual analysis of moral stress among health care workers during the COVID-19 pandemic 

      Gustavsson, Martina E; von Schreeb, Johan; Arnberg, Filip K; Juth, Niklas (Inst för global folkhälsa / Dept of Global Public Health, 2024-01-31)
      Background Health care workers (HCWs) are susceptible to moral stress and distress when they are faced with morally challenging situations where it is difficult to act in line with their moral standards. In times of crisis, ...

    • Reduced variability of bursting activity during working memory 

      Lundqvist, Mikael; Rose, Jonas; Brincat, Scott L; Warden, Melissa R; Buschman, Timothy J; Herman, Pawel; Miller, Earl K; Lundqvist, Mikael (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)
      Working memories have long been thought to be maintained by persistent spiking. However, mounting evidence from multiple-electrode recording (and single-trial analyses) shows that the underlying spiking is better characterized ...

    • Working memory control dynamics follow principles of spatial computing 

      Lundqvist, Mikael; Brincat, Scott L; Rose, Jonas; Warden, Melissa R; Buschman, Timothy J; Miller, Earl K; Herman, Pawel; Lundqvist, Mikael (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-01-30)
      Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts of beta and gamma oscillations. However, it is not clear how ...

    • Moral stress among Swedish health care workers during the COVID-19 pandemic : a cross-sectional study 

      Gustavsson, Martina E; Juth, Niklas; von Schreeb, Johan; Arnberg, Filip K (Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)
      Aims: This study quantifies to what extent Health care workers (HCWs) experienced moral stress and to what extent their experiences of moral stress were related to gender and age as well as to working directly with COVID-19 ...

    • Dealing with difficult choices : a qualitative study of experiences and consequences of moral challenges among disaster healthcare responders 

      Gustavsson, Martina E; Juth, Niklas; Arnberg, Filip K; von Schreeb, Johan (Inst för global folkhälsa / Dept of Global Public Health, 2023-12-21)
      Background: Disasters are chaotic events with healthcare needs that overwhelm available capacities. Disaster healthcare responders must make difficult and swift choices, e.g., regarding who and what to prioritize. Responders ...

    • Pregnancy outcomes in women with a prior cervical intraepithelial neoplasia grade 3 diagnosis : a nationwide population-based cohort study with sibling comparison design 

      He, Wei; Sparén, Pär; Fang, Fang; Sengpiel, Verena; Strander, Björn; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)
      Background: Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) removes or destroys part of the cervix and might subsequently influence pregnancy outcomes. Objective: To investigate pregnancy outcomes in women ...

    • Heritability of mammographic breast density, density change, microcalcifications, and masses 

      Holowko, Natalie; Eriksson, Mikael; Kuja-Halkola, Ralf; Azam, Shadi; He, Wei; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)
      Background: Mammographic features influence breast cancer risk and are used in risk prediction models. Understanding how genetics influence mammographic features is important since the mechanisms through which they are ...

    • Chemotherapy, genetic susceptibility, and risk of venous thromboembolism in breast cancer patients 

      Brand, Judith S; Hedayati, Elham; Humphreys, Keith; Ludvigsson, Jonas F; Johansson, Anna L V; Bergh, Jonas; Hall, Per; Czene, Kamila (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-10-25)
      Purpose: Venous thromboembolism (VTE) is highly heritable and a serious complication of cancer and its treatment. We examined the individual and joint effects of chemotherapy and genetic susceptibility on VTE risk in ...

    • MicroRNA-210 regulates dendritic morphology and behavioural flexibility in mice 

      Watts, Michelle; Williams, Gabrielle; Lu, Jing; Nithianantharajah, Jess; Claudianos, Charles (Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2023-08-16)
      MicroRNAs are known to be critical regulators of neuronal plasticity. The highly-conserved, hypoxia- regulated microRNA-210 (miR-210) has been shown to be associated with long term memory in invertebrates and dysregulated ...

    • Could dietary nitrate affect dementia development? 

      Carballo-Casla, Adrián; Dunk, Michelle M.; Donat-Vargas, Carolina; Xu, Weili (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2023-08-16)