Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics
C8 (MEB)
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Evaluation of new and current preventive strategies for cervical and vaginal cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-05-08)This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ... -
Exploring statistical models for estimating remaining life years & loss in life expectancy for cancer patients
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-03-08)As advancements in cancer prognosis and treatment continue for many cancer types, there is a growing interest in estimating survival over longer time periods. The assessment of the years remaining after a cancer diagnosis, ... -
On suicide and self-harm in university students and outcomes in persons with bipolar disorder and their offspring
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-01-05)Suicide is one of the leading causes of death in young persons in Sweden and globally. The last decades have seen an increasing proportion of the youth population engaging in university level education. The university ... -
Appeasing the wheezing : determinants and outcomes of respiratory disease in childhood
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-01-03)The aim of this thesis was to study the determinants and outcomes asthma and cystic fibrosis in childhood by using study populations of persons born in Sweden and data from a clinical cohort and national health and demographic ... -
Mental illness in chronic kidney disease : prognosis, drug utilization, and treatment outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-12-11)Chronic kidney disease (CKD) is a common yet heterogeneous condition, covering a wide spectrum of disease severity ranging from mildly decreased kidney function to kidney failure. Patients with CKD can often encounter ... -
Pregnancy outcomes in women with a prior cervical intraepithelial neoplasia grade 3 diagnosis : a nationwide population-based cohort study with sibling comparison design
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)Background: Treatment of cervical intraepithelial neoplasia grade 3 (CIN3) removes or destroys part of the cervix and might subsequently influence pregnancy outcomes. Objective: To investigate pregnancy outcomes in women ... -
Heritability of mammographic breast density, density change, microcalcifications, and masses
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-27)Background: Mammographic features influence breast cancer risk and are used in risk prediction models. Understanding how genetics influence mammographic features is important since the mechanisms through which they are ... -
Genetic epidemiology of depression subgroups and suicide attempts
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-17)Major depressive disorder (MDD) is a common psychiatric disorder, affecting 20% of the global population. Individuals with MDD exhibit variable disease manifestations, aetiologies, and treatment responses. This heterogeneity ... -
Genetic and environmental factors influencing the risk and course of eating disorders
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-11-07)Eating disorders are debilitating conditions characterized by dysregulated eating and/or weight-control behaviors leading to significant impairment of psychosocial functioning and/or physical health. Both environmental ... -
Chemotherapy, genetic susceptibility, and risk of venous thromboembolism in breast cancer patients
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-10-25)Purpose: Venous thromboembolism (VTE) is highly heritable and a serious complication of cancer and its treatment. We examined the individual and joint effects of chemotherapy and genetic susceptibility on VTE risk in ... -
Potential overtreatment during life-limiting illness and end of life in older adults
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-10-11)Background. A growing body of evidence suggests that older patients are subject to potential overtreatment at the end of life, characterised by disease modifying therapies, preventive medications, and frequent care ... -
Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-10-09)Frailty is an age-related, dynamic state of multisystem physiological decline and is a strong predictor of disability and mortality. To move towards an individualized management of frailty, a better understanding of its ... -
Artificial intelligence in histopathology image analysis for cancer precision medicine
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-09-29)In recent years, there have been rapid advancements in the field of computational pathology. This has been enabled through the adoption of digital pathology workflows that generate digital images of histopathological ... -
Epidemiological studies on breast cancer risk factors and screening
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-09-27)This thesis aims to enhance cancer prevention by investigating the factors and outcomes associated with false-positive (FP) mammography recalls, as well as understanding the association between breast cancer risk factors ... -
Epidemiological aspects of type 1 diabetes : early life origins, childhood comorbidities, and adult outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-09-04)Type 1 diabetes is an autoimmune disease, often with onset during childhood, that requires lifelong insulin therapy due to the loss of pancreatic beta-cells. Several aspects of type 1 diabetes epidemiology remained to be ... -
Comorbidity between neurodevelopmental disorders and childhood-onset type 1 diabetes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-08-28)Childhood-onset type 1 diabetes and neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and intellectual disability, globally represent substantial health ... -
The general factor of psychopathology : precursors and consequences
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-08-03)Comorbidity among different types of psychopathology is very common whether they are treated as discrete diagnostic categories or continuous dimensions. Empirical methods to describing these dimensions of dysfunction and ... -
Prognosis of nasopharyngeal carcinoma : body mass index, plasma Epstein-Barr virus DNA and oral microbiome
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-05-29)Nasopharyngeal carcinoma (NPC) has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. Although hospital-based studies suggest that the development of new radiotherapy ... -
Adjuvant hormone therapy in breast cancer patients : a special focus on treatment discontinuation
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-04-19)Purpose: Breast cancer is the most common cancer among women, with approximately 80% of cases being estrogen-receptor (ER) positive. Adjuvant hormone therapy is a standard treatment that is recommended for ER-positive ... -
Beyond mammography : an evaluation of complementary modalities in breast imaging
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2023-03-31)Breast cancer is the main cause of cancer death among women worldwide and the goal of mammography screening is to reduce breast cancer-specific mortality. The reduction of the sensitivity of mammography for detecting cancer ...