Avhandlingar / Theses: Recent submissions
Now showing items 1-20 of 9553
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Evaluation of new and current preventive strategies for cervical and vaginal cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2024-05-08)This thesis addresses clinical research questions on primary and secondary prevention of cervical and vaginal cancer by targeting four groups of women in the organized cervical screening program; women entering the screening ... -
Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Major lower extremity amputations : outcomes, complications, and patient perspectives
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-07)An amputation is considered to be one of the oldest surgical procedures; yet, despite advancements in medical care, it continues to be associated with high rates of complications and postoperative mortality. This thesis ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ... -
Pyrocarbon in shoulder hemi arthroplasty
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Pyrolytic carbon, or pyrocarbon (PyC), has biocompatibility, a low friction coefficient and good wear resistance, making it a material of great potential for use in orthopaedics. PyC shoulder implants have shown promising ... -
Diet, genetic susceptibility, latent autoimmune diabetes in adults, type 1 and type 2 diabetes
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-03)Diabetes is one of the most common chronic diseases, yet our understanding of modifiable risk factors remains incomplete. This project aimed to elucidate the role of diet in the risk of latent autoimmune diabetes in adults ... -
Hepatic diseases at the molecular level : identifying novel targets and biomarkers through transcriptomics
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2024-05-03)In the last few decades, the prevalence of obesity and metabolic diseases have dramatically increased and pose a major threat to global healthcare systems. The chronic excess of carbohydrates and fat is a risk factor for ... -
Mortality prediction and equity in emergency care
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-05-03)Introduction: Emergency departments (EDs) face crowding and long patient waiting times due to resource-demand imbalances. Waiting exposes patients to sufferings and risks, such as pain, anxiety, permanent organ damage, or ... -
Impact of non-health sector determinants on child health the role of the Sustainable Development Goals : models, practices and perceptions in Cambodia and globally
(Inst för global folkhälsa / Dept of Global Public Health, 2024-05-02)Background. Child health has improved significantly over the last decades in Cambodia and globally. With the global adoption of the Sustainable Development Goals (SDGs) in 2015, a broad set of interlinked global goals to ... -
Surgical treatment of lung cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-02)Background: Surgery is a central part in the treatment of lung cancer. There have been recent advances in minimal invasive and lung sparing surgical techniques, but evidence regarding safety and implementability is not ... -
Automated microfluidic-based production of PET radioligands for clinical and preclinical use
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-02)In recent decades, microfluidic technologies have been explored for PET radiopharmaceutical production. Moreover, radiotracer production models have been gradually transitioning from centralized to decentralized models ... -
Sexual health in young adult survivors of childhood cancer : prevalence, predictors and web-based support
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-02)Aim: The overall aim of this thesis was to investigate the prevalence of sexual activity and dysfunction in young adult survivors (19-40 years) of childhood cancer in comparison to the general population. A further aim was ... -
Exposures through drinking water and risk of chronic disease
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-02)Drinking water is the most important constituent of our diet. Yet, the importance of drinking water quality for population health is understudied. The overall aim of this thesis was to increase this knowledge by examining ... -
Exploring allergic and irritant contact dermatitis : biomarkers, mechanisms, and allergen uptake
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-30)Contact dermatitis (CD) is a common disease resulting from direct skin contact with allergens or irritants and greatly affects the life quality of suffering individuals. It is categorized into two main forms, namely allergic ... -
Immune responses after SARS-CoV-2 infection and/or vaccination
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2024-04-30)From the start of the COVID-19 pandemic, it was clear that studying immune responses after SARS-CoV-2 infection and later on, after vaccination, was of outmost importance in battling the pandemic. To understand immunological ... -
Neuromuscular electrical stimulation in physical inactivity
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-04-30)Physical inactivity and immobilization have emerged as major health issues. Neuromuscular electrical stimulation (NMES) is a potential treatment to prevent the negative effects of physical inactivity, such as muscle atrophy ... -
Catheter ablation of atrial fibrillation : methods for improving outcome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-30)Introduction: The most common arrhythmia world-wide is atrial fibrillation (AF). The arrhythmia is diagnosed through an electrocardiogram (ECG). Patients with AF often experience symptoms including palpitations, dyspnoea, ... -
Volumetric and cortical brain development and outcome in children born extremely preterm
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-04-30)Children born extremely preterm (EPT) survive at an increasing rate. But they continue to have an increased risk for neurodevelopmental impairments. Magnetic resonance imaging (MRI) is used in a clinical setting, but can ...