Evaluation of isovolumic myocardial motions in human subjects using tissue velocity echocardiography
Author: Lind, Britta
Date: 2006-04-07
Location: Föreläsningssal 4V, plan 4, Alfred Nobels allé 8, Karolinska Institutet, Huddinge
Time: 9.00
Department: Institutionen för laboratoriemedicin / Department of Laboratory Medicine
Abstract
Colour-coded tissue velocity imaging (TVE) with Echocardiography is an established method for evaluation of the global cardiac function and of the regional myocardial movements. The TVE-technique allows measurements of velocity and deformation variables from any discrete point in the myocardial wall during the cardiac cycle with high temporal and longitudinal spatial resolution. Even the rapid kinetic events during the isovolumic phases can be analysed which has been reported to be involved in the process of pre and postsystolic ventricular reshaping. However, the optimal sampling requirements for a proper rendering of the tissue velocity variables and the effect of different temporal smoothing filters incorporated in the WE software have not yet been established.
The aims for current thesis were to establish optimal values for temporal resolution and also to study the effect of temporal filtering algorithms on colour-coded tissue derived duration and velocity variables registered at the base of left ventricle in apical views. After ensuring adequate sampling rate and temporal filter width for the myocardial velocity profiles the isovolumic periods were analysed in fortynine healthy subjects to describe normal reference values in the base of four different cardiac walls. The influence of gender and age were also studied for isovolumic time, velocity variables as well their respectively amplitude motion. The reproducibility for the longitudinal and radial myocardial velocity and displacement variables was studied and varied between 5-12% (CV).
The temporal resolution should at least 100 frames/s for a proper rendering of the myocardial velocity variables during the entire cardiac cycle. Increased temporal filter width affected the results by decreased myocardial velocities and the effect was most pronounced during the rapid isovolumic events. The longitudinal motions of left ventricular wall showed biphasic patterns during the isovolumic contraction and relaxation periods and the segmental velocities and displacements differs among the four walls. The relative myocardial isovolumic displacement was most pronounced in anterior wall (5.0 of the total longitudinal myocardial shortening). Except prolonged duration of the TVE-IVRT in the older age group, no other larger gender and age differences occurred.
The aims for current thesis were to establish optimal values for temporal resolution and also to study the effect of temporal filtering algorithms on colour-coded tissue derived duration and velocity variables registered at the base of left ventricle in apical views. After ensuring adequate sampling rate and temporal filter width for the myocardial velocity profiles the isovolumic periods were analysed in fortynine healthy subjects to describe normal reference values in the base of four different cardiac walls. The influence of gender and age were also studied for isovolumic time, velocity variables as well their respectively amplitude motion. The reproducibility for the longitudinal and radial myocardial velocity and displacement variables was studied and varied between 5-12% (CV).
The temporal resolution should at least 100 frames/s for a proper rendering of the myocardial velocity variables during the entire cardiac cycle. Increased temporal filter width affected the results by decreased myocardial velocities and the effect was most pronounced during the rapid isovolumic events. The longitudinal motions of left ventricular wall showed biphasic patterns during the isovolumic contraction and relaxation periods and the segmental velocities and displacements differs among the four walls. The relative myocardial isovolumic displacement was most pronounced in anterior wall (5.0 of the total longitudinal myocardial shortening). Except prolonged duration of the TVE-IVRT in the older age group, no other larger gender and age differences occurred.
List of papers:
I. Gaballa M, Lind B, Storaa C, Brodin LA (2001). Intra- and interobserver reproducibility in off-line extracted cardiac tissue Doppler velocity measurements and derived variables. Proc of IEEE. Engineering in Medicine and Biology. 4-6: 1.
II. Lind B, Nowak J, Dorph J, van der Linden J, Brodin LA (2002). Analysis of temporal requirements for myocardial tissue velocity imaging. Eur J Echocardiogr. 3(3): 214-9.
Pubmed
III. Gunnes S, Storaa C, Lind B, Nowak J, Brodin LA (2004). Analysis of the effect of temporal filtering in myocardial tissue velocity imaging. J Am Soc Echocardiogr. 17(11): 1138-45.
Pubmed
IV. Lind B, Nowak J, Cain P, Quintana M, Brodin LA (2004). Left ventricular isovolumic velocity and duration variables calculated from colour-coded myocardial velocity images in normal individuals. Eur J Echocardiogr. 5(4): 284-93.
Pubmed
V. Lind B, Eriksson M, Roumina S, Nowak J, Brodin LA (2006). Longitudinal isovolumic displacement of the left ventricular myocardium assessed by tissue velocity echocardiography in healthy individuals. J Am Soc Echocardiogr. 19(3): 255-65.
Pubmed
I. Gaballa M, Lind B, Storaa C, Brodin LA (2001). Intra- and interobserver reproducibility in off-line extracted cardiac tissue Doppler velocity measurements and derived variables. Proc of IEEE. Engineering in Medicine and Biology. 4-6: 1.
II. Lind B, Nowak J, Dorph J, van der Linden J, Brodin LA (2002). Analysis of temporal requirements for myocardial tissue velocity imaging. Eur J Echocardiogr. 3(3): 214-9.
Pubmed
III. Gunnes S, Storaa C, Lind B, Nowak J, Brodin LA (2004). Analysis of the effect of temporal filtering in myocardial tissue velocity imaging. J Am Soc Echocardiogr. 17(11): 1138-45.
Pubmed
IV. Lind B, Nowak J, Cain P, Quintana M, Brodin LA (2004). Left ventricular isovolumic velocity and duration variables calculated from colour-coded myocardial velocity images in normal individuals. Eur J Echocardiogr. 5(4): 284-93.
Pubmed
V. Lind B, Eriksson M, Roumina S, Nowak J, Brodin LA (2006). Longitudinal isovolumic displacement of the left ventricular myocardium assessed by tissue velocity echocardiography in healthy individuals. J Am Soc Echocardiogr. 19(3): 255-65.
Pubmed
Issue date: 2006-03-17
Publication year: 2006
ISBN: 91-7140-651-4
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