Now showing items 21-40 of 326

  • Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux 

    Maret-Ouda, John; Wahlin, Karl; El-Serag, Hashem B.; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-09)
    IMPORTANCE: Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence ...
  • Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo) 

    Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-03-06)
    PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare ...
  • Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-02-12)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...
  • Serum proteases potentiate BMP-induced cell cycle re-entry of dedifferentiating muscle cells during newt limb regeneration 

    Wagner, Ines; Wang, Heng; Weissert, Philipp; Straube, Werner; Shevchenko, Anna; Gentzel, Marc; Brito, Goncalo; Tazaki, Akira; Oliveira, Catarina; Sugiura, Takuji; Shevchenko, Andrej; Simon, András; Drechsel, David; Tanaka, Elly (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-02-12)
    Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic ...
  • Limited association between markers of stress during pregnancy and fetal growth in “Born into Life”, a new prospective birth cohort 

    Smew, Awad Idris; Hedman, Anna M.; Chiesa, Flaminia; Ullemar, Vilhelmina; Andolf, Ellika; Pershagen, Göran; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-02-12)
    AIMS: We aimed to investigate the associations between perceived maternal stress or salivary cortisol levels during pregnancy and birth weight. METHODS: In 2010-2012 we recruited 92 women living in Stockholm, ...
  • Tenascin-C and fibronectin in normal esophageal mucosa, Barrett's esophagus, dysplasia and adenocarcinoma. 

    Kauppila, Joonas Henrikki; Bogdanoff, Sara; Leppänen, Joni; Lehenkari, Petri; Saarnio, Juha; Karttunen, Tuomo; Huhta, Heikki; Helminen, Olli (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: Tenascin-C and fibronectin are adhesive glycoproteins modulating the structure of the extracellular matrix and cellular functions. Their expression and function in esophageal adenocarcinoma is ...
  • Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease : a systematic review and meta-analysis 

    Flanigan, Catherine; Sheikh, Aziz; DunnGalvin, Audrey; Brew, Bronwyn K; Almqvist, Catarina; Nwaru, Bright I (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-01-31)
    BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary-axis (HPA), leading to Th2-biased cell differentiation ...
  • Meta-analysis of health-related quality of life after minimally invasive versus open oesophagectomy for oesophageal cancer. 

    Kauppila, Joonas Henrikki; Xie, Shaohua; Johar, Asif; Markar, Sheraz; Lagergren, Pernilla (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-31)
    BACKGROUND: The aim of this systematic review and meta-analysis was to compare health-related quality of life (HRQoL) outcomes between minimally invasive and open oesophagectomy for cancer at different postoperative time ...
  • Skeletal muscle dedifferentiation during salamander limb regeneration 

    Wang, Heng; Simon, Andras (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2018-01-24)
    Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been ...
  • Neoadjuvant therapy in relation to lymphadenectomy and resection margins during surgery for oesophageal cancer. 

    Kauppila, Joonas Henrikki; Wahlin, Karl; Lagergren, Pernilla; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-17)
    It is unclear whether gastrectomy or oesophagectomy offer better outcomes for gastro-oesophageal junction (GOJ) cancer. A total of 240 patients undergoing total gastrectomy (n = 85) or oesophagectomy (n = ...
  • Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study 

    Peura, Sari; Fall, Tove; Almqvist, Catarina; Andolf, Ellika; Hedman, Anna; Pershagen, Göran; Helmersson-Karlqvist, Johanna; Larsson, Anders (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-01-11)
    Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a ...
  • Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease – a population-based study 

    Örtqvist, Anne K; Lundholm, Cecilia; Halfvarson, Jonas; Ludvigsson, Jonas F; Almqvist, Catarina (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-01-11)
    Objective Earlier studies on antibiotics exposure and development of IBD (Crohn’s disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association ...
  • All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study) 

    Ness-Jensen, Eivind; Gottlieb-Vedi, Eivind; Wahlin, Karl; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-11)
    OBJECTIVE: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of ...
  • Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loc 

    Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and ...
  • Quality of life and psychological and gastrointestinal symptoms after cholecystectomy : a population-based cohort study 

    Talseth, Arne; Edna, Tom-Harald; Hveem, Kristian; Lydersen, Stian; Ness-Jensen, Eivind (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    OBJECTIVE: The study aims to examine gastrointestinal symptoms, quality of life and the risk of psychological symptoms after cholecystectomy. DESIGN: This is a prospective population-based cohort study based ...
  • Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease 

    Ness-Jensen, Eivind; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2018-01-08)
    Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include ...
  • Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder : a pilot study 

    Tangen, Ämma; Borg, Jacqueline; Tiger, Mikael; Varnäs, Katarina; Sorjonen, Kimmo; Lindefors, Nils; Halldin, Christer; Lundberg, Johan (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2018-01-04)
    The neurotransmitter serotonin has been widely implicated in the pathophysiology of major depressive disorder (MDD). In animal studies and human neuroimaging studies, involvement of the serotonin receptor 1B (5-HT1BR) in ...
  • Education in twins and their parents across birth cohorts over 100 years : an individual-level pooled analysis of 42 twin cohorts 

    Silventoinen, Karri; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Yokoyama, Yoshie; Ullemar, Vilhelmina; Almqvist, Catarina; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth JF; Kandler, Christian; Honda, Chika; Inui, Fujio; Iwatani, Yoshinori; Watanabe, Mikio; Rebato, Esther; Stazi, Maria A; Fagnani, Corrado; Brescianini, Sonia; Hur, Yoon-Mi; Jeong, Hoe-Uk; Cutler, Tessa L; Hopper, John L; Busjahn, Andreas; Kaprio, Jaakko (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-12-22)
    Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed ...
  • A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders 

    Mataix-Cols, David; Frans, Emma; Pérez-Vigil, Ana; Kuja-Halkola, Ralf; Gromark, Caroline; Isomura, Kayoko; Fernández de la Cruz, Lorena; Serlachius, Eva; Leckman, James F; Crowley, James J; Rück, Christian; Almqvist, Catarina; Lichtenstein, Paul; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-11-29)
    The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns ...
  • Why doesn’t everyone love reading e-books? 

    Myrberg, Caroline (Karolinska Institutet Universitetsbiblioteket / Karolinska Institutet University Library7404042983, 2017-11-15)
    Why do many students still prefer paper books to e-books? This article summarizes a number of problems with e-books mentioned in different studies by students of higher education, but it also discusses some of the ...