Molecular epidemiology of pneumococcal carriage and invasive disease
Author: Sjöström, Karin
Date: 2007-02-23
Location: Föreläsningssalen Gard-aulan, Smittskyddsinstitutet, Nobels väg 18, Solna
Time: 09.00
Department: Institutionen för mikrobiologi, tumör- och cellbiologi / Department of Microbiology, Tumor and Cell Biology
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thesis.pdf (4.503Mb)
Abstract
Streptococcus pneumoniae, also known as pneumococcus, is a major
contributor to morbidity and mortality worldwide. It is the main cause of
respiratory tract infections such as otitis media and sinusitis, but also
causes millions of deaths each year due to pneumonia, meningitis and
septicemia, especially among children and the elderly. Pneumococci are
frequently carried in the nasopharynx of healthy children attending day
care centers, where up to 70% may be colonised. The purpose of the
studies within this thesis was to investigate the molecular epidemiology
of invasive pneumococcal disease and carriage, as well as the spread and
mechanisms for spread of pneumococcal isolates with a reduced
susceptibility to penicillin.
Invasive and carriage isolates from the same period of time and the same
geographic area were compared. Depending on serotypes the isolates could
be grouped into at least two classes. One class caused mainly invasive
disease (serotype 1, 4, 7F and 9V) and the other class included serotypes
found both among carriers and patients with invasive disease (6A, 6B, 14
and 19F). Moreover, serotypes and clones of invasive isolates were
correlated to clinical parameters such as the APACHE 11 score (a
measurement of severity of disease at admittance to the hospital), age,
mortality, underlying disease and pneumococcal disease type. Serotype 1
and 7F isolates were found genetically highly related within each
serotype. These types caused invasive disease mainly in young adults and
previously healthy individuals, suggesting that type 1 and 7F might act
as primary pathogens. In contrast, serotype 19F and 11 A caused disease
mainly in elderly patients with underlying diseases, suggesting these
types to act as opportunistic pathogens. An emerging frequency of
antibiotic resistant pneumococci has been observed globally. During
1997-2003, in Sweden, the prevalence of PNSP (isolates with a reduced
susceptibility to penicillin) remained stable around 2%, even though the
prescription of antibiotics decreased. However, the prevalence of multi
resistant isolates increased. Among PNSP, serotype 14 increased due to
one clonal cluster, the internationally spread clone Spain9v-3 with STI
56. One reason for the successful spread was suggested to be the presence
of adhesive pilus-like structures encoded by the rIrA islet. In
conclusion, pneumococcal serotype in combination with clonal type is
important for disease outcome. Furthermore, the recently identified
pneumococcal pili may be important for successful spread of antibiotic
resistant Streptococcus pneumoniae.
List of papers:
I. Sandgren A, Sjostrom K, Olsson-Liljequist B, Christensson B, Samuelsson A, Kronvall G, Henriques Normark B (2004). "Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae." J Infect Dis 189(5): 785-96. Epub 2004 Feb 16
Pubmed
II. Sjostrom K, Spindler C, Ortqvist A, Kalin M, Sandgren A, Kuhlmann-Berenzon S, Henriques-Normark B (2006). "Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen." Clin Infect Dis 42(4): 451-9. Epub 2006 Jan 17
Pubmed
III. Hogberg L, Ekdahl K, Sjostrom K, Olsson-Liljequist B, Walder M, Melander E, Ringberg H, Normark BH (2006). "Penicillin-resistant pneumococci in Sweden 1997-2003: increased multiresistance despite stable prevalence and decreased antibiotic use." Microb Drug Resist 12(1): 16-22
Pubmed
IV. Sjostrom K, Blomberg C, Fernebro J, Dagerhamn J, Morfeldt E, Barocchi M, Browall S, Moschioni M, Andersson M, Albiger B, Henriques F, Rappuoli R, Normark S, Henriques-Normark B (2006). "Clonal success of piliated penicillin non-susceptible Pneumococci" (Submitted)
I. Sandgren A, Sjostrom K, Olsson-Liljequist B, Christensson B, Samuelsson A, Kronvall G, Henriques Normark B (2004). "Effect of clonal and serotype-specific properties on the invasive capacity of Streptococcus pneumoniae." J Infect Dis 189(5): 785-96. Epub 2004 Feb 16
Pubmed
II. Sjostrom K, Spindler C, Ortqvist A, Kalin M, Sandgren A, Kuhlmann-Berenzon S, Henriques-Normark B (2006). "Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen." Clin Infect Dis 42(4): 451-9. Epub 2006 Jan 17
Pubmed
III. Hogberg L, Ekdahl K, Sjostrom K, Olsson-Liljequist B, Walder M, Melander E, Ringberg H, Normark BH (2006). "Penicillin-resistant pneumococci in Sweden 1997-2003: increased multiresistance despite stable prevalence and decreased antibiotic use." Microb Drug Resist 12(1): 16-22
Pubmed
IV. Sjostrom K, Blomberg C, Fernebro J, Dagerhamn J, Morfeldt E, Barocchi M, Browall S, Moschioni M, Andersson M, Albiger B, Henriques F, Rappuoli R, Normark S, Henriques-Normark B (2006). "Clonal success of piliated penicillin non-susceptible Pneumococci" (Submitted)
Issue date: 2007-02-02
Rights:
Publication year: 2007
ISBN: 978-91-7357-094-7
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