Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset: Recent submissions
Now showing items 41-60 of 257
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Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ... -
Bridging the gap in asthma management among adolescents and young adults
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-04)Background: Asthma can develop at any age. During childhood, the prevalence of asthma is higher in boys, but after puberty it grows higher in girls. The goals of asthma treatment are to achieve and maintain asthma control ... -
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ... -
Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence and early life ... -
New aspects on timing and graft morbidity in anterior cruciate ligament reconstruction
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-12-28)The aim of this thesis was to investigate the effect of different surgical techniques on knee function and outcomes after an anterior cruciate ligament (ACL) reconstruction (ACLR). In Study I, 70 patients with a ... -
Non-conveyed patients : a thesis on epidemiology, and patients' and ambulance clinicians' experiences
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-25)BACKGROUND: As a consequence of the increased overall number of ambulance assignments in combination with an increase in patients assessed as having non-urgent complaints, new demands are being placed on the ambulance ... -
Pregnancies with decreased fetal movements : risk factors and strategies for mitigation of poor neonatal outcomes
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-18)Background and aims: The most feared complication of pregnancy is stillbirth. Globally there are 2.6 million stillbirths annually with more than 7000 deaths a day. Pregnancies with reduced fetal movements have a higher ... -
Screening for silent cardiac disease in an elderly population aiming at stroke reduction
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-11-09)INTRODUCTION: Atrial Fibrillation is the most common clinical arrhythmia and affects over 30 million people worldwide. Atrial fibrillation is a leading cause of morbidity and mortality worldwide with death, stroke and heart ... -
Blood pressure in atrial fibrillation
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-06)Introduction: Hypertension is a leading risk factor for cardiovascular morbidity and premature death. Prevalence of hypertension in the adult population in Sweden has been estimated to 27%. Atrial fibrillation (AF) is the ... -
Distal radius fractures : epidemiology and aspects of surgical management
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-06)Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ... -
Pharmacological prevention of ischemic stroke and TIA : epidemiological aspects and how to improve treatment
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-10-19)Background: Medications can prevent stroke but are not used optimally. The overarching aim of this thesis was to study medication use in patients with previous ischemic stroke or transient ischemic attack (TIA) and in all ... -
Clinical quality and performance measurement in the prehospital emergency medical services in the low-to-middle-income setting : developing clinical quality and performance indicators as a measure of care in South Africa
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-08)BACKGROUND: Measuring quality and safety in any healthcare setting however is highly contextual, and depends on the manner in which quality is defined or viewed within that setting. It is this contextual nature that has ... -
Pregnancies complicated by obesity : focus on stillbirth and infants born large for gestational age
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-07)Background: The prevalence of obesity has increased globally and reached pandemic levels. Obesity is associated with increased risks of complications during conception, pregnancy and delivery as well as during the postpartum ... -
Studies of cell-on-chip technology and basophil regulation for improved allergy diagnostics
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-08-17)Allergic diseases affect approximately 30% of adults and has an impact on both the individual’s quality of life as well as an economic impact on society. Two effector cells involved in allergic disease are mast cells and ... -
Redesigning an emergency department for interprofessional teamwork : a longitudinal evaluation of the impact on patient flow and team behaviour
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-19)Objective: Crowding in emergency departments (EDs) has negative effects on patients and staff, whereas effective teamwork in healthcare has positive effects. Triage interventions and streaming of specific patient categories ... -
Surgeon-performed ultrasound and timing of surgery in acute cholecystitis
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-15)Introduction: The use of bedside ultrasound has increased, as equipment has become accessible, user friendly, and ultrasound education is expanding in many specialties. The aim of this project was to validate surgeon-performed ... -
The value of new sonographic modalities, demographic, biometric and proliferative variables for the risk prediction in endometrial cancer
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-11)Background: Endometrial cancer is the sixth most common type of cancer among women worldwide and constitutes 4.8% of all cancer in women. The incidence is highest in high-income countries, given how age and obesity are the ... -
Coronary angiography in out-of-hospital cardiac arrest : why, when and for whom?
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-02-27)Study I. A national observational retrospective study, evaluating the effect on survival of early coronary angiography vs. no early coronary angiography in witnessed, unconscious OHCA patients with shockable rhythm and ... -
Prognostic factors for whiplash associated disorders
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-02-21)Disability and chronic pain secondary to low- speed vehicle collisions has been a known condition since the nineteenth century. Today, whiplash-associated disorders (WAD) are the most common personal injuries reported to ... -
Female pelvic floor disorders : clinical aspects on surgical treatments
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-02-07)Background and aims: The life-time risk for a woman to undergo pelvic floor reconstructive surgery due to prolapse or incontinence is 20% and the high risk for recurrence after prolapse surgery is a major challenge. Surgical ...