Now showing items 1-20 of 212

    • Population-based analyses of incidence, prognostic determinants and outcome of aortic dissection 

      Smedberg, Christian (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-09-02)
      Background: Aortic dissection (AD) is a potentially life-threatening disease caused by a tear in the innermost layer of the aortic wall, the intima, resulting in blood flow between the layers of the aortic vessel wall. ...
    • Cardiovascular risk assessments in peripheral arterial disease : results of a ten-year follow-up of a Swedish population-based cohort 

      Sartipy, Fredrik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-05-20)
      Background An updated knowledge on natural history in Peripheral Arterial Disease (PAD) is lacking, in particular for the asymptomatic stage (APAD). The disease has strong associations with other atherosclerotic ...
    • Closing the abdominal wall in high-risk abdominal surgery 

      Söderbäck, Harald (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-05-12)
      Background: Incisional hernia and Wound dehiscence are potentially serious complications to midline incisions. Recent studies have shown that a meticulous suturing technique can reduce the rate of these complications ...
    • Translational studies on mechanical hemostasis and coagulopathy in trauma 

      Brännström, Andreas (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-05-07)
      Trauma, in terms of physical injury, is the leading cause of death and disability among children and young adults worldwide. Hemorrhage and coagulation dysfunction are two important causes of preventable deaths after ...
    • Communication, coping and social networking regarding infertility 

      Sormunen, Taina (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-04-29)
      Infertility is a worldwide problem and is experienced as psychologically stressful. Communication about infertility varies depending on clinical aspects, personal relationships, and culture. The aim of this thesis was ...
    • Diagnosis of dog allergy in children : molecular assessment and refined characterization 

      Käck, Ulrika (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-26)
      Dog allergy is a common cause of rhinitis and asthma in children, yet the diagnosis is a clinical challenge. Allergic sensitization, i.e. the presence of serum IgE antibodies, to dog dander affect up to 30 % of all children ...
    • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age 

      Merid, Simon Kebede; Novoloaca, Alexei; Sharp, Gemma C.; Kupers, Leanne K.; Kho, Alvin T.; Roy, Ritu; Gao, Lu; Annesi-Maesano, Isabella; Jain, Pooja; Plusquin, Michelle; Kogevinas, Manolis; Allard, Catherine; Vehmeijer, Florianne O.; Kazmi, Nabila; Salas, Lucas A.; Rezwan, Faisal I.; Zhang, Hongmei; Sebert, Sylvain; Czamara, Darina; Rifas-Shiman, Sheryl L.; Melton, Phillip E.; Lawlor, Debbie A.; Pershagen, Göran; Breton, Carrie V.; Huen, Karen; Baiz, Nour; Gagliardi, Luigi; Nawrot, Tim S.; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; Nohr, Ellen Aagaard; Bustamante, Mariona; Ewart, Susan L.; Karmaus, Wilfried; Zhao, Shanshan; Page, Christian M.; Herceg, Zdenko; Jarvelin, Marjo-Riitta; Lahti, Jari; Baccarelli, Andrea A.; Anderson, Denise; Kachroo, Priyadarshini; Relton, Caroline L.; Bergström, Anna; Eskenazi, Brenda; Soomro, Munawar Hussain; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; Jaddoe, Vincent W.; Sorensen, Thorkild I. A.; Vrijheid, Martine; Arshad, S. Hasan; Holloway, John W.; Haberg, Siri E.; Magnus, Per; Dwyer, Terence; Binder, Elisabeth B.; DeMeo, Dawn L.; Vonk, Judith M.; Newnham, John; Tantisira, Kelan G.; Kull, Inger; Wiemels, Joseph L.; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Munthe-Kaas, Monica C.; Raikkonen, Katri; Oken, Emily; Huang, Rae-Chi; Weiss, Scott T.; Anto, Josep Maria; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catarina; Cardenas, Andres; Gruzieva, Olena; Xu, Cheng-Jian; Reese, Sarah E.; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matthias; Holland, Nina; Ghantous, Akram; Hivert, Marie-France; Felix, Janine F.; Koppelman, Gerard H.; London, Stephanie J.; Melen, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)
      Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
    • Bridging the gap in asthma management among adolescents and young adults 

      Ödling, Maria (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-04)
      Background: Asthma can develop at any age. During childhood, the prevalence of asthma is higher in boys, but after puberty it grows higher in girls. The goals of asthma treatment are to achieve and maintain asthma control ...
    • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure 

      Merid, Simon Kebede; Bustamante, Mariona; Standl, Marie; Sunyer, Jordi; Heinrich, Joachim; Lemonnier, Nathanaël; Aguilar, Daniel; Antó, Josep Maria; Bousquet, Jean; Santa-Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, SödersjukhusetKarolinska Institutet, 2021-02-09)
      Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
    • Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE 

      Wang, Gang; Hallberg, Jenny; Bergström, Petra Um; Janson, Christer; Pershagen, Göran; Gruzieva, Olena; van Hage, Marianne; Georgelis, Antonios; Bergström, Anna; Kull, Inger; Lindén, Anders; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)
      BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence ...
    • New aspects on timing and graft morbidity in anterior cruciate ligament reconstruction 

      Essen, Christoffer von (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-12-28)
      The aim of this thesis was to investigate the effect of different surgical techniques on knee function and outcomes after an anterior cruciate ligament (ACL) reconstruction (ACLR). In Study I, 70 patients with a ...
    • Non-conveyed patients : a thesis on epidemiology, and patients’ and ambulance clinicians’ experiences 

      Lederman, Jakob (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-25)
      BACKGROUND As a consequence of the increased overall number of ambulance assignments in combination with an increase in patients assessed as having non-urgent complaints, new demands are being placed on the ambulance ...
    • Pregnancies with decreased fetal movements : risk factors and strategies for mitigation of poor neonatal outcomes 

      Sterpu, Irene (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-18)
      Background and aims: The most feared complication of pregnancy is stillbirth. Globally there are 2.6 million stillbirths annually with more than 7000 deaths a day. Pregnancies with reduced fetal movements have a higher ...
    • Screening for silent cardiac disease in an elderly population aiming at stroke reduction 

      Kemp Guðmundsdóttir, Katrín Ragna (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-11-09)
      INTRODUCTION: Atrial Fibrillation is the most common clinical arrhythmia and affects over 30 million people worldwide. Atrial fibrillation is a leading cause of morbidity and mortality worldwide with death, stroke and heart ...
    • Blood pressure in atrial fibrillation 

      Olbers, Joakim (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-06)
      Introduction: Hypertension is a leading risk factor for cardiovascular morbidity and premature death. Prevalence of hypertension in the adult population in Sweden has been estimated to 27%. Atrial fibrillation (AF) is the ...
    • Distal radius fractures : epidemiology and aspects of surgical management 

      Rundgren, Johanna (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-11-06)
      Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ...
    • Pharmacological prevention of ischemic stroke and tia : epidemiological aspects and how to improve treatment 

      Geary, Lukas (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-10-19)
      Background: Medications can prevent stroke but are not used optimally. The overarching aim of this thesis was to study medication use in patients with previous ischemic stroke or transient ischemic attack (TIA) and ...
    • Clinical quality and performance measurement in the prehospital emergency medical services in the low-to-middle-income setting : developing clinical quality and performance indicators as a measure of care in South Africa 

      Howard, Ian (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-08)
      BACKGROUND: Measuring quality and safety in any healthcare setting however is highly contextual, and depends on the manner in which quality is defined or viewed within that setting. It is this contextual nature that has ...
    • Pregnancies complicated by obesity : focus on stillbirth and infants born large for gestational age 

      Åmark, Hanna (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-09-07)
      Background: The prevalence of obesity has increased globally and reached pandemic levels. Obesity is associated with increased risks of complications during conception, pregnancy and delivery as well as during the postpartum ...
    • Studies of cell-on-chip technology and basophil regulation for improved allergy diagnostics 

      Kalm, Frida (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-08-17)
      Allergic diseases affect approximately 30% of adults and has an impact on both the individual’s quality of life as well as an economic impact on society. Two effector cells involved in allergic disease are mast cells and ...