Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 405
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Ready to pull : force transmission during vascular development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-12-17)The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ... -
Regulation of chromatin transitions in the 3D architecture of the nucleus
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-27)The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation ... -
Long non-coding RNAs and cellular interactions : investigating underlying mechanisms of oncogenesis
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-06)Cancer is a leading cause of death worldwide with one in 8 men and one in 11 women dying from the disease (World Health Organization, 2018). Despite vast improvements in cancer diagnosis and therapy, the global cancer ... -
Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-09-26)Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy ... -
Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-08-08)Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of ... -
Consequences of inadequate use of glucose lowering drugs and associated risk factors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-21)Diabetes Mellitus is characterized by chronically elevated blood glucose levels, hyperglycaemia. Consistent adherence to appropriate glucose-lowering drug therapy is fundamental to prevent disease progression, diabetes-related ... -
Evaluation of postmortem toxicological results
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-20)Postmortem diagnosis of fatal intoxications is complicated. Autopsy findings indicative of an intoxication related death are scarce and mostly unspecific. Instead, the diagnosis is more dependent on the circumstances ... -
Molecular mechanisms of human mitochondrial dynamics : inspiration and challenge
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-15)Mitochondria are highly dynamic organelles in cells. They frequently change the morphology via continuous fission and fusion events, referred to as mitochondrial dynamics, which includes the shape, size and number of ... -
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-03)The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ... -
From risk indices to reconstitution of immunity : studies of outcome-related factors in patients undergoing allogeneic hematopoietic stem cell transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-02)Allogeneic hematopoietic stem cell transplantation (HSCT) is a potent immunotherapeutic procedure which has the possibility to cure otherwise lethal hematological diseases. Its usability in clinical practice is limited by ... -
Genetic and morphological studies of tumor heterogeneity, multifocality and outcome in locally advanced prostate cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-04-12)Prostate cancer is a leading cause of mortality worldwide. Patients with locally advanced disease have a higher risk of relapse after treatment with curative intent. Examples of risk factors are seminal vesicle invasion ... -
Feeling the force : role of AmotL2 in normal development and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-03-21)Cells that fabricate the body, dwell in a very heterogeneous environment. Self-organization of individual cells into complex tissues and organs at the time of growth and revival is brought about by the combinatory action ... -
Cripto-1: potential target for cancer immunotherapy?!
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-02-20)Cancer immunotherapy refers to the stimulation of the immune system to eliminate cancer cells and can be applied by several different means. One form of cancer immunotherapy is therapeutic vaccination with the goal to ... -
Person-centered shift handovers in oncological inpatient care
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-01-31)Surveys show that patients are not sufficiently involved in decisions and planning regarding their own care, and patients have reported unfulfilled information needs in inpatient settings. To develop inpatient cancer care ... -
Transcriptional gene signatures : passing the restriction point for routine clinical implementation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-01-03)Uncontrolled cell growth and cell division are central to the process of tumorigenesis and a number of gene expression signatures have been developed based on genes that are involved in the cell cycle. Notably, gene ... -
Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-29)Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being ... -
Fishing for cures : the zebrafish as a powerful tool to identify novel therapies against glioblastoma by targeting MTH1 and beyond
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-27)Glioblastoma (GBM) is the most aggressive form of brain cancer. Despite today’s combinatory therapy consisting of surgery, radio- and chemotherapy, the prognosis remains dismal. Fostered by extensive tumor heterogeneity, ... -
War and peace in the tumor microenvironment : tumor-associated cells as facilitators or adversaries during tumor development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-23)The tumor microenvironment, including immune cells, fibroblasts and vasculature, profoundly affects tumor development by initially opposing, but eventually facilitating tumor growth, vascularization and spread. Though ... -
Impact of alcohol and drug abuse on hippocampal neurogenesis in humans
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-16)Hippocampus is one of the few brain regions in which adult neurogenesis is known to occur. Adult neurogenesis in the hippocampus is considered to be important for higher cognitive function, most notably in memory processes ... -
Human papillomavirus and other molecular markers in cancer of different oropharyngeal sub-sites
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-09)Background: Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPSCC), and over the past few decades OPSCC has increased drastically due to an HPV epidemic. The oropharynx contains different ...