Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 413
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Prognosis based classification and tumor biology of uterine sarcomas
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-05-15)Uterine stromal sarcomas are a heterogenous group of tumors ranging from low-grade stromal sarcomas with a relatively good survival but high risk of recurrence, to undifferentiated uterine sarcomas with a far worse ... -
Targeted therapy in chronic lymphocytic leukemia
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-28)Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. Historically, patients with TP53 aberration and with refractoriness to ... -
Hitting the right targets : a study of molecular mediators of sensitivity to novel potential targeted therapies in cutaneous malignant melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-24)Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer with a 5-year overall survival (OS) rate of less than 10% among patients diagnosed with disseminated disease. During the past decade the emergence and ... -
Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer: biology and clinical implications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-04-03)Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed ... -
Studies of side effects related to adjuvant breast cancer regimens with focus on chemotherapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-03-26)Radiotherapy, endocrine therapy, chemotherapy and targeted therapy adjunct to surgery have a critical role in the management of early breast cancer for outcome improvement. Anthracycline containing chemotherapy reduces ... -
Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-02-18)The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence ... -
Investigation of small-cell lung cancer epidemiology in Sweden and analysis of clinical and tumor specific prognostic biomarkers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-02-10)Small-cell lung cancer (SCLC) accounts for approximately 13% of all newly diagnosed lung cancer (LC) cases. This disease is correlated with heavy smoking. It is characterized by a rapid doubling time combined with a ... -
Coordination of gene expression programs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-01-24)Most cellular processes depend on the activity and interactions of proteins. The proteome, i.e. the entire set of proteins in a specific condition, is shaped by regulation of transcription, mRNA-degradation, -processing, ... -
Ready to pull : force transmission during vascular development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-12-17)The transmission of mechanical forces controls a multitude of cellular processes such as migration, the formation of new organs, muscle contraction, and resistance to the continuous stress that blood flow exerts on the ... -
Regulation of chromatin transitions in the 3D architecture of the nucleus
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-27)The thesis explores the dynamic features and functions of chromatin crosstalk in the 3D nucleus space, with a focus on the regulation of chromatin transitions. In Paper I we employed the circular chromosome conformation ... -
Long non-coding RNAs and cellular interactions : investigating underlying mechanisms of oncogenesis
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-11-06)Cancer is a leading cause of death worldwide with one in 8 men and one in 11 women dying from the disease (World Health Organization, 2018). Despite vast improvements in cancer diagnosis and therapy, the global cancer ... -
Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-09-26)Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy ... -
Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-08-08)Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of ... -
Consequences of inadequate use of glucose lowering drugs and associated risk factors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-21)Diabetes Mellitus is characterized by chronically elevated blood glucose levels, hyperglycaemia. Consistent adherence to appropriate glucose-lowering drug therapy is fundamental to prevent disease progression, diabetes-related ... -
Evaluation of postmortem toxicological results
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-20)Postmortem diagnosis of fatal intoxications is complicated. Autopsy findings indicative of an intoxication related death are scarce and mostly unspecific. Instead, the diagnosis is more dependent on the circumstances ... -
Molecular mechanisms of human mitochondrial dynamics : inspiration and challenge
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-15)Mitochondria are highly dynamic organelles in cells. They frequently change the morphology via continuous fission and fusion events, referred to as mitochondrial dynamics, which includes the shape, size and number of ... -
Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-03)The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, ... -
From risk indices to reconstitution of immunity : studies of outcome-related factors in patients undergoing allogeneic hematopoietic stem cell transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-05-02)Allogeneic hematopoietic stem cell transplantation (HSCT) is a potent immunotherapeutic procedure which has the possibility to cure otherwise lethal hematological diseases. Its usability in clinical practice is limited by ... -
Genetic and morphological studies of tumor heterogeneity, multifocality and outcome in locally advanced prostate cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-04-12)Prostate cancer is a leading cause of mortality worldwide. Patients with locally advanced disease have a higher risk of relapse after treatment with curative intent. Examples of risk factors are seminal vesicle invasion ... -
Feeling the force : role of AmotL2 in normal development and cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-03-21)Cells that fabricate the body, dwell in a very heterogeneous environment. Self-organization of individual cells into complex tissues and organs at the time of growth and revival is brought about by the combinatory action ...