Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 439
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Assessment of prognostic factors of prostate cancer : limitations and possibilities of morphology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-07)Prostate cancer is a leading cause of cancer morbidity and mortality. It is a morphologically, genetically, and clinically heterogeneous disease. Stage and grade are important predictors of patient outcome. Extraprostatic ... -
Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-06)Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways ... -
Advancing antiviral strategies against emerging RNA viruses by phenotypic drug discovery
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-21)Pathogenic RNA viruses can emerge from unexpected sources at unexpected times and cause severe disease in humans, as exemplified by the ongoing coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory ... -
Improving endometrial carcinoma diagnostics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-08)Endometrial carcinoma is the most common gynecological malignancy and greatly affects global disease burden. Despite it being among the most common cancers it is relatively understudied and until recently poorly understood. ... -
Cell and organoid models to develop new antivirals and diagnostic methods for emerging viruses
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-08)The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is only the latest reminder of the urgent need for new antiviral strategies and diagnostic tools to improve preparedness for ... -
From natural to eximious : harnessing the power of natural killer cells against solid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-01)Cancer heterogeneity, which enables clonal survival and treatment resistance, is shaped by active immune responses. Unchallenged results from clinical trials show the power of stimulating our immune system to attack tumor ... -
Developing analytical tools to investigate the role of translation in homeostasis and disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-03-31)Transcriptome-wide studies of translation efficiencies are required to improve understanding of translational regulation and its role in homeostatic mechanisms. In Study 1, we developed an algorithm for analysis of ... -
Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-22)Drugs inhibiting the MAPK-pathway (MAPKi) and immune checkpoint inhibitors (ICI) have changed the clinical outcome of metastatic cutaneous malignant melanoma (CMM) in a significant way. Nonetheless, many patients have ... -
Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-11)Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ... -
Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-01-12)The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome ... -
Assisted reproductive technologies for fertility preservation and fertility treatment in young women with cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2020-12-30)Loss of fertility as a potential side effect of anti-neoplastic treatments may have a significant negative impact on the survivors’ quality of life. Assisted reproductive technologies (ART) have been adapted and further ... -
Tumors of the adrenal glands : genetic and diagnostic aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Adrenal tumors have varying clinical presentation, malignancy rates and patient morbidity. Adrenal cortical carcinomas (ACCs) are malignant tumors originating from the adrenal cortex. Pheochromocytomas (PCCs) arise from ... -
Radiation dose and related risk in interventional cardiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Cardiac catheterization procedures are classified as high radiation dose procedures, European Directive 2013/59/Euratom, and may result in skin injuries (deterministic effects) and/or increased cancer risk (stochastic ... -
Real-world studies on B-cell malignancies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-18)Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and ... -
Biomarkers for CNS metastasis in non-small cell lung cancer (NSCLC)
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-18)Non-small cell lung cancer (NSCLC) comprises more than 75% of lung cancer cases and is usually diagnosed in advanced stages. Lung cancer is the leading cause of cancer death among all solid tumours and the second most ... -
Low-dose methadone as add-on to ongoing opioid treatment in cancer-related pain
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-17)Background: In complex cancer-related pain in imminently dying patients, even high doses of ordinary opioids may have an insufficient effect. The addition of low-dose methadone to another ongoing opioid has been proposed ... -
Radiation dose and x-ray beam modelling in diagnostic and interventional radiology using Monte Carlo methods
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-03)Although medical imaging is essential for the diagnosis and treatment of a wide range of medical conditions, the radiation dose from x-ray examinations is one of the largest contributors to the exposure of the world’s ... -
Improving chemotherapy in advanced urothelial cancer : real-world data studies and prospective clinical trials
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-23)Advanced urothelial cancer (UC) is an aggressive disease with high morbidity and mortality. The primary aim of this thesis was to improve chemotherapy with respect to treatment efficacy, safety, and health-related quality ... -
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-08)The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ... -
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-07)In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...