Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 446
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MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Long-term follow-up after risk-reducing mastectomy and immediate breast reconstruction : from a patient, partner, and 3D perspective
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-10)BACKGROUND: Breast cancer is the most common type of cancer among women. Approximately 5–10% of all breast cancer cases have an inherited pattern, and ~20% of all hereditary cases have an identifiable mutation. Through ... -
Autophagy and VPS34 as targets in anti-cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-08-20)Autophagy (Greek for self-eating) is a cellular pathway that breaks down cytoplasmic components to fuel metabolism. In this way, autophagy maintains cellular homeostasis and sustains survival during stress conditions. In ... -
Genetic and molecular characterization of follicular thyroid tumors : diagnostic and prognostic aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-08-16)Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and it sometimes metastasize to lungs and bone. A substantial subset of these tumors lacks an identified driver event and no well-established ... -
Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues ... -
Exploring mTOR-dependent regulation of mRNA translation in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation ... -
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ... -
Assessment of prognostic factors of prostate cancer : limitations and possibilities of morphology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-07)Prostate cancer is a leading cause of cancer morbidity and mortality. It is a morphologically, genetically, and clinically heterogeneous disease. Stage and grade are important predictors of patient outcome. Extraprostatic ... -
Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-06)Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways ... -
Advancing antiviral strategies against emerging RNA viruses by phenotypic drug discovery
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-21)Pathogenic RNA viruses can emerge from unexpected sources at unexpected times and cause severe disease in humans, as exemplified by the ongoing coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory ... -
Improving endometrial carcinoma diagnostics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-08)Endometrial carcinoma is the most common gynecological malignancy and greatly affects global disease burden. Despite it being among the most common cancers it is relatively understudied and until recently poorly understood. ... -
Cell and organoid models to develop new antivirals and diagnostic methods for emerging viruses
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-08)The ongoing global pandemic of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is only the latest reminder of the urgent need for new antiviral strategies and diagnostic tools to improve preparedness for ... -
From natural to eximious : harnessing the power of natural killer cells against solid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-04-01)Cancer heterogeneity, which enables clonal survival and treatment resistance, is shaped by active immune responses. Unchallenged results from clinical trials show the power of stimulating our immune system to attack tumor ... -
Developing analytical tools to investigate the role of translation in homeostasis and disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-03-31)Transcriptome-wide studies of translation efficiencies are required to improve understanding of translational regulation and its role in homeostatic mechanisms. In Study 1, we developed an algorithm for analysis of ... -
Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-22)Drugs inhibiting the MAPK-pathway (MAPKi) and immune checkpoint inhibitors (ICI) have changed the clinical outcome of metastatic cutaneous malignant melanoma (CMM) in a significant way. Nonetheless, many patients have ... -
Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-11)Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ... -
Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-01-12)The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome ... -
Assisted reproductive technologies for fertility preservation and fertility treatment in young women with cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2020-12-30)Loss of fertility as a potential side effect of anti-neoplastic treatments may have a significant negative impact on the survivors’ quality of life. Assisted reproductive technologies (ART) have been adapted and further ... -
Tumors of the adrenal glands : genetic and diagnostic aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Adrenal tumors have varying clinical presentation, malignancy rates and patient morbidity. Adrenal cortical carcinomas (ACCs) are malignant tumors originating from the adrenal cortex. Pheochromocytomas (PCCs) arise from ... -
Radiation dose and related risk in interventional cardiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Cardiac catheterization procedures are classified as high radiation dose procedures, European Directive 2013/59/Euratom, and may result in skin injuries (deterministic effects) and/or increased cancer risk (stochastic ...