Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 457
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Untangling the contribution of untranslated regions to mRNA translation in health and disease
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2022-01-19)Protein homeostasis is essential for living organisms and a consequence of steps of the gene expression pathway such as transcription, mRNA translation as well as the degradation of mRNA and proteins. These major cellular ... -
Molecular biomarkers in melanoma susceptibility and therapy response
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-30)Melanoma accounts for the majority of the mortality from all types of skin cancers. Five to ten percent of the cases are familial melanoma, yet more than 50% of the melanoma families cannot be explained by established ... -
The DNA repair enzymes MTH1 and OGG1 as targets to treat inflammation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-25)Chronic and acute inflammatory diseases, such as multiple sclerosis (MS), psoriasis and sepsis, account for vast disability and morbidity in the world. Several new immunomodulating treatment alternatives have been developed ... -
Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-25)Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common ... -
At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-19)The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies ... -
Novel in vitro methods aiming at improving fertility preservation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-11)The well-established fertility preservative methods for female cancer patients include the cryopreservation of embryos, mature oocytes and ovarian tissue before the initiation of gonadotoxic cancer treatment. Due to a ... -
ROR1 − a druggable target : preclinical studies of ROR1 and combinatorial partners in malignancies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-11-11)Cancer cells are masters of adaption, and their ability to sustain proliferative signaling presents a complicated challenge to cancer treatment. Therefore, novel drugs that attack key drivers of cancer cell growth are ... -
Uniquely NK cells: the multifaceted roles of the natural killers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-28)Natural killer cells (NK cells) were primarily discovered through the study of tumor cell recognition during immune surveillance. Till date, many studies had characterized NK cells to have immune regulatory roles in both ... -
Fertility-sparing surgery in young women with ovarian cancer and borderline ovarian tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-21)Background: Based on the cell origin of the tumor, ovarian cancer (OC) is divided in epithelial ovarian cancer (EOC), including borderline ovarian tumors (BOT), and nonepithelial ovarian cancer (NEOC), which includes sex ... -
Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-05)The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote ... -
Deciphering the complexity of biological systems using machine learning applied to big data
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-10-01)With the rising of the omics era and the recent technological advancements in biology and medicine, the generated data is growing exponentially. Increasing the volume of the data in parallel to complexity and heterogeneity ... -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-16)T cell-driven diseases account for considerable morbidity and disability globally and there is an urgent need for new targeted therapies. Both cancer cells and activated T cells have an altered redox balance, and up-regulate ... -
Long-term follow-up after risk-reducing mastectomy and immediate breast reconstruction : from a patient, partner, and 3D perspective
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-09-10)BACKGROUND: Breast cancer is the most common type of cancer among women. Approximately 5–10% of all breast cancer cases have an inherited pattern, and ~20% of all hereditary cases have an identifiable mutation. Through ... -
Autophagy and VPS34 as targets in anti-cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-08-20)Autophagy (Greek for self-eating) is a cellular pathway that breaks down cytoplasmic components to fuel metabolism. In this way, autophagy maintains cellular homeostasis and sustains survival during stress conditions. In ... -
Genetic and molecular characterization of follicular thyroid tumors : diagnostic and prognostic aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-08-16)Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and it sometimes metastasize to lungs and bone. A substantial subset of these tumors lacks an identified driver event and no well-established ... -
Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues ... -
Exploring mTOR-dependent regulation of mRNA translation in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)Modulation of mRNA translation via the mammalian target of rapamycin (mTOR) pathway is primarily achieved by integrating internal or external signals onto the translation machinery, especially on the rate-limiting initiation ... -
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-06-01)The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ... -
Assessment of prognostic factors of prostate cancer : limitations and possibilities of morphology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-07)Prostate cancer is a leading cause of cancer morbidity and mortality. It is a morphologically, genetically, and clinically heterogeneous disease. Stage and grade are important predictors of patient outcome. Extraprostatic ... -
Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-05-06)Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways ...