Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 432
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Molecular markers for prediction of response and progression free survival to novel therapies in cutaneous malignant melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-22)Drugs inhibiting the MAPK-pathway (MAPKi) and immune checkpoint inhibitors (ICI) have changed the clinical outcome of metastatic cutaneous malignant melanoma (CMM) in a significant way. Nonetheless, many patients have ... -
Mechanisms of cancer cell death by mutant p53-reactivating compound APR-246
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-02-11)Tumor suppressor TP53 is the most frequently mutated gene in cancer. A majority of TP53 mutations result in a mutant p53 that disrupts its DNA binding capabilities but may also acquire novel gain-of-function activities ... -
Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2021-01-12)The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome ... -
Assisted reproductive technologies for fertility preservation and fertility treatment in young women with cancer
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2020-12-30)Loss of fertility as a potential side effect of anti-neoplastic treatments may have a significant negative impact on the survivors’ quality of life. Assisted reproductive technologies (ART) have been adapted and further ... -
Tumors of the adrenal glands : genetic and diagnostic aspects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Adrenal tumors have varying clinical presentation, malignancy rates and patient morbidity. Adrenal cortical carcinomas (ACCs) are malignant tumors originating from the adrenal cortex. Pheochromocytomas (PCCs) arise from ... -
Radiation dose and related risk in interventional cardiology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-12-21)Cardiac catheterization procedures are classified as high radiation dose procedures, European Directive 2013/59/Euratom, and may result in skin injuries (deterministic effects) and/or increased cancer risk (stochastic ... -
Real-world studies on B-cell malignancies
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-18)Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and ... -
Biomarkers for CNS metastasis in non-small cell lung cancer (NSCLC)
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-18)Non-small cell lung cancer (NSCLC) comprises more than 75% of lung cancer cases and is usually diagnosed in advanced stages. Lung cancer is the leading cause of cancer death among all solid tumours and the second most ... -
Low-dose methadone as add-on to ongoing opioid treatment in cancer-related pain
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-17)Background: In complex cancer-related pain in imminently dying patients, even high doses of ordinary opioids may have an insufficient effect. The addition of low-dose methadone to another ongoing opioid has been proposed ... -
Radiation dose and x-ray beam modelling in diagnostic and interventional radiology using Monte Carlo methods
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-11-03)Although medical imaging is essential for the diagnosis and treatment of a wide range of medical conditions, the radiation dose from x-ray examinations is one of the largest contributors to the exposure of the world’s ... -
Improving chemotherapy in advanced urothelial cancer : real-world data studies and prospective clinical trials
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-23)Advanced urothelial cancer (UC) is an aggressive disease with high morbidity and mortality. The primary aim of this thesis was to improve chemotherapy with respect to treatment efficacy, safety, and health-related quality ... -
Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-08)The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. This thesis ... -
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-07)In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ... -
p53 and cancer-associated fibroblasts : implications for cancer therapy and drug resistance
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-10-01)Drug resistance remains as a major problem and a daunting challenge to successful anticancer treatment. Cancer cells are masters of adaptation. Novel drugs that attack cancer in new ways and target key drivers of cancer ... -
MicroRNA and energy metabolism in gastrointestinal tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-09-09)MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in ... -
Improving biomarker assessment in breast pathology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-09-02)The accuracy of prognostic and therapy-predictive biomarker assessment in breast tumours is crucial for management and therapy decision in patients with breast cancer. In this thesis, biomarkers used in clinical practice ... -
Individualized Prostate Cancer Testing : men's views on participation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-08-19)Prostate cancer (PCa) is the second most common cancer in men in the world and the fourth most common occurring cancer overall. However, because the harms from testing with prostate-specific antigen (PSA) are considered ... -
Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-08-06)Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs ... -
Understanding the response to EGFR targeting therapy in non-small-cell lung cancer using -omics approach
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-07-21)NSCLC is the leading cause of cancer-related death worldwide. EGFR targeted therapy is used to inhibit the progress of NSCLC, but patients inevitably develop resistance to EGFRTKIs. The work presented in this thesis ... -
Prognosis based classification and tumor biology of uterine sarcomas
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-05-15)Uterine stromal sarcomas are a heterogenous group of tumors ranging from low-grade stromal sarcomas with a relatively good survival but high risk of recurrence, to undifferentiated uterine sarcomas with a far worse ...