Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 380
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Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ... -
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-25)Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ... -
Understanding p53 structure and targeting mutant p53 for improved cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-24)The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA-binding domains but have rather different functions. The tumor suppressor p53 acts as the ... -
Mass spectrometry based proteomics : data analysis and applications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-08)Mass spectrometry (MS) based proteomics has become a widely used high throughput method to investigate protein expression and functional regulation. From being able to study only dozens of proteins, state-of-art MS ... -
Exploring mechanisms regulating the heterogeneity of Tumor-Associated Macrophages
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-03)Accumulation of macrophages in the tumor microenvironment is associated to poor prognoses in most human cancers. Tumor-associated macrophages (TAMs) represent a heterogeneous and plastic population of cells that contribute ... -
Human papillomavirus and other biomarkers in neck masses of unknown origin and in head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)Background. Human papillomavirus (HPV) is, in addition to smoking and alcohol, a risk factor for developing oropharyngeal squamous cell carcinoma (OPSCC), and more specifically tonsillar- and base of tongue squamous cell ... -
Discovery and validation of prognostic markers for cutaneous melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)During the last years there has been an alarming increase in incidence of cutaneous melanoma (CMM) which is the deadliest form of skin cancer. There has been a paradigm shift in treatment of disseminated stage IV disease ... -
WRAP53β and scaRNA2 on their journey to repair the DNA
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-22)WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and ... -
Fatal attraction : NK cell migration toward and activity in solid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-14)Natural killer (NK) cells play a key role in tumor immunosurveillance due to their ability to induce apoptosis of tumor cells and produce pro-inflammatory cytokines, without prior immune sensitization. In particular, NK ... -
Vaginal morphological changes in cervical cancer survivors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-02-02)Background: Cervical cancer is globally the fourth most common cancer in women and has generally a good prognosis. Cervical cancer survivors report persistent changes in their sexual function, which result in considerable ... -
Prognostic factors in breast cancer with a focus on the role of tumour proliferation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-01-26)Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer ... -
MicroRNAs and their processing factors in Caenorhabditis elegans and human cancers
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-01-04)MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-22 nucleotides (nt) long. These small RNAs (sRNAs) was initially discovered in Caenorhabditis elegans (C. elegans), but is conserved in over 50 animal species. ... -
Functional analysis of long non-coding RNAs in cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-24)For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ... -
Tumor microenvironment derived biomarkers in renal cell cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-16)Renal cell carcinoma (RCC) is the 13th most common malignancy worldwide, and constitutes around 2% of all malignant tumors. The entity renal cell carcinoma comprises a heterogenous group of malignant tumors that originates ... -
Genetic studies in familial non-BRCA breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-11-09)Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. ... -
Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome‐wide analyses
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-09-11)Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling ... -
Insulin-like growth factor 1 receptor, novel functions and future possibilities
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-09-01)Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces ... -
Validation of biomarkers and digital image analysis in breast pathology
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-08-21)For women worldwide, the risk of developing breast cancer is second only to that of nonmelanoma skin cancer. Significant improvements have been made in survival over the past decades and today about 80 % of the patients ... -
The challenge of co-existence : from graft-versus-host disease to stable mixed chimerism after allogeneic hematopoietic stem cell transplantation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-08-08)The only curative treatment strategy for many hematologic and inborn immunodeficiency disorders is an allogeneic hematopoietic stem cell transplantation (HSCT). The treatment involves replacing the entire hematopoietic ... -
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-07-25)The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ...