Inst för onkologi-patologi / Dept of Oncology-Pathology: Recent submissions
Now showing items 1-20 of 391
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Transcriptional gene signatures : passing the restriction point for routine clinical implementation
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2019-01-03)Uncontrolled cell growth and cell division are central to the process of tumorigenesis and a number of gene expression signatures have been developed based on genes that are involved in the cell cycle. Notably, gene ... -
Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-29)Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being ... -
Fishing for cures : the zebrafish as a powerful tool to identify novel therapies against glioblastoma by targeting MTH1 and beyond
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-27)Glioblastoma (GBM) is the most aggressive form of brain cancer. Despite today’s combinatory therapy consisting of surgery, radio- and chemotherapy, the prognosis remains dismal. Fostered by extensive tumor heterogeneity, ... -
War and peace in the tumor microenvironment : tumor-associated cells as facilitators or adversaries during tumor development
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-23)The tumor microenvironment, including immune cells, fibroblasts and vasculature, profoundly affects tumor development by initially opposing, but eventually facilitating tumor growth, vascularization and spread. Though ... -
Impact of alcohol and drug abuse on hippocampal neurogenesis in humans
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-16)Hippocampus is one of the few brain regions in which adult neurogenesis is known to occur. Adult neurogenesis in the hippocampus is considered to be important for higher cognitive function, most notably in memory processes ... -
Human papillomavirus and other molecular markers in cancer of different oropharyngeal sub-sites
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-11-09)Background: Human papillomavirus (HPV) is a known risk factor for oropharyngeal cancer (OPSCC), and over the past few decades OPSCC has increased drastically due to an HPV epidemic. The oropharynx contains different ... -
Multimodality treatment of oesophageal cancer : effects and side effects
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-10-22)Background: Oesophageal cancer is highly fatal and treatment with curative intent is beset with many side effects. Treatment options are (1) chemoradiotherapy, (2) chemotherapy with or without the addition of radiotherapy ... -
Tumor-associated macrophages and microglia : double-edged sword in tumor evolvement and invasion
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-10-02)Tumor-associated macrophages (TAMs) are among the most abundant cell types in the tumor microenvironment. TAM infiltration is usually linked to tumor progression, metastasis and poor clinical outcome in most human cancers. ... -
Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-08-29)Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, ... -
The role of autophagy in anticancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-08-24)Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject ... -
A study of two major challenges in prostate cancer : effective chemo-prevention and overcoming resistance to hormonal and chemotherapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-06-29)For men, over the course of a lifetime the risk of developing prostate cancer is 1 in 9. Both the illness itself and treatment affect quality of life in multiple aspects, including urinary problems, pain, and sexual ... -
Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-30)A large fraction of human tumors carry inactivating mutations in the TP53 tumor suppressor gene. Approximately 75% of these mutations are missense mutations and around 10% are nonsense mutations. TP53 inactivation allows ... -
Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-25)Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors ... -
Understanding p53 structure and targeting mutant p53 for improved cancer therapy
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-24)The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA-binding domains but have rather different functions. The tumor suppressor p53 acts as the ... -
Mass spectrometry based proteomics : data analysis and applications
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-08)Mass spectrometry (MS) based proteomics has become a widely used high throughput method to investigate protein expression and functional regulation. From being able to study only dozens of proteins, state-of-art MS ... -
Exploring mechanisms regulating the heterogeneity of Tumor-Associated Macrophages
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-05-03)Accumulation of macrophages in the tumor microenvironment is associated to poor prognoses in most human cancers. Tumor-associated macrophages (TAMs) represent a heterogeneous and plastic population of cells that contribute ... -
Human papillomavirus and other biomarkers in neck masses of unknown origin and in head and neck cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)Background. Human papillomavirus (HPV) is, in addition to smoking and alcohol, a risk factor for developing oropharyngeal squamous cell carcinoma (OPSCC), and more specifically tonsillar- and base of tongue squamous cell ... -
Discovery and validation of prognostic markers for cutaneous melanoma
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-04-13)During the last years there has been an alarming increase in incidence of cutaneous melanoma (CMM) which is the deadliest form of skin cancer. There has been a paradigm shift in treatment of disseminated stage IV disease ... -
WRAP53β and scaRNA2 on their journey to repair the DNA
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-22)WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and ... -
Fatal attraction : NK cell migration toward and activity in solid tumors
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2018-03-14)Natural killer (NK) cells play a key role in tumor immunosurveillance due to their ability to induce apoptosis of tumor cells and produce pro-inflammatory cytokines, without prior immune sensitization. In particular, NK ...