Inst för laboratoriemedicin / Dept of Laboratory Medicine: Recent submissions
Now showing items 21-40 of 467
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Characterizing and exploiting the endocytic pathway for macromulecular delivery
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-04-29)Macromolecular drugs with cytosolic or nuclear targets often exhibit low therapeutic activity due, at least in part, to their inability to escape endosomal compartments following cellular internalization. There exist a ... -
Immunometabolic regulation in natural HIV-1 control
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-04-28)The elite controllers (EC) are a rare group of people living with HIV-1 infection (PLHIV) that can control viral replication in the absence of antiretroviral therapy for a prolonged time. The mechanisms behind elite control ... -
Evaluation of vaccine candidates for HIV prevention in Tanzania
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-04-21)Background: This thesis describes the capability of an HIV-1 DNA and HIV-1 modified vaccinia virus Ankara (MVA) prime boost vaccination strategy to elicit immune responses known to correlate with reduced risk of HIV ... -
Cancer associated fibroblasts and T cells in pancreatic cancer : an immune perspective
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-04-21)About 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC) and its deadly hallmarks, including a prominent fibrotic stroma, low mutational burden, lack of early diagnosis and rapid metastasis, contribute ... -
Engineered extracellular vesicles for biomedical applications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-12-28)Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The ... -
Studies of nuclear encoded mitochondrial proteins in metabolism
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-11-19)Mitochondrial function is vital for human health. Inherited genetic disease can cause mitochondrial DNA (mtDNA) deficiency, disorders with generally poor prognosis. The majority of the genesinvolved in keeping a normal ... -
Muscular aging and its relation to physical activity and function : longitudinal and cross-sectional analyses
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-11-09)With age, muscle mass decreases and muscle function and strength decline, which is associated with loss of independence, hospitalization, morbidity and mortality. The aim of this thesis was to investigate the mechanisms ... -
Physical capacity, physical activity and skeletal muscle in heart failure : studies of pathophysiology
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-15)The overall aim of the present thesis was to provide a better understanding of the pathophysiology of heart failure (HF), especially to explore possible mechanistic links between the failing heart and the periphery, as ... -
Gene regulation in normal and malignant B-lineage cells
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-13)B-cells are the central players of humoral immunity. It is known that their development is orchestrated by a small group of transcription factors including the E-proteins and the FOXO proteins, yet this process is far from ... -
Anti-gene oligonucleotides : DNA binding and therapeutic application
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-10-01)The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics ... -
Dynamic changes in chemotactic and metabolic properties in tumor cells undergoing TGFb1-induced Epithelial-Mesenchymal Transition (EMT)
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-09-30)Epithelial-Mesenchymal Transition (EMT) is a process linked to several hallmarks of cancer including metabolic switching, inflammation, and chemotactic properties. Tumor cells that undergo EMT lose epithelial characteristics ... -
Pharmaceutical insights into improving oligonucleotide delivery and efficacy
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-08-13)The power of gene therapy lies in their capacity to target a disease on a genetic level. Nucleic acid containing therapeutics can be utilized to treat, diagnose or prevent a possible disease or condition. However, the ... -
Optimization of intermittent preventive therapy for malaria during pregnancy : effectiveness of dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-28)Malaria is a Tropical disease caused by different parasites species of genius Plasmodium. Because of pregnancy associated lowered immunity, women who are pregnant are at higher risk to malaria infection than non-pregnant ... -
Pancreatic cancer : investigation of the prognostic significance of tumor immunophenotype and establishment of a novel ex-vivo tissue slice culture system for drug sensitivity testing
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-27)Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, is associated with a dismal 5-year overall survival of 9 to 6 %. A major reason for the high mortality is the pronounced resistance to ... -
Novel combination chemotherapy for treatment and control of schistosomiasis among school children
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-21)Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate schistosomiasis, partly due to its poor efficacy against ... -
Human papillomavirus as a target for cancer prevention
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-12)If we would know more about virus causing cancer, we would have the possibility to prevent the disease. Human Papillomavirus (HPV) causes cervical cancer and is one of the world’s most common sexually transmitted diseases ... -
Novel injectable calcium sulfate depot formulations for local cancer treatment
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-07)In the present thesis, a novel drug delivery technology named NanoZolid® based on hydrating inorganic calcium sulfate, is investigated. NanoZolid is injected as a liquid suspension of calcium sulfate, which solidifies in ... -
Translational studies of syndecan-1 as angiogenesis inhibitor : from basic research to clinical applications
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-05-03)Malignant mesothelioma (MM) is a highly aggressive primary tumor of the pleura, associated with poor prognosis. MM is mainly related to exposure to mineral fibers such as asbestos. The diagnosis of MM, despite multiple ... -
In vitro and in vivo studies of Bruton tyrosine kinase (BTK) mutations and inhibition
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-04-14)Bruton tyrosine kinase (BTK) is a non-receptor protein kinase that belongs to the TEC family kinases. It plays an important role in the B-cell receptor signaling pathway (BCR) and its pharmacological inhibition has been ... -
Modelling and genetic correction of liver genetic diseases
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-03-24)The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being ...