Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition: Recent submissions

Now showing items 21-40 of 316

    • Inhibition in cognition : neurophysiology and connectivity of gabaergic interneurons in the prefrontal cortex 

      Lunteren, Josina Anna van (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-11-12)
      The prefrontal cortex (PFC) is a cortical region involved in higher-order cognitive functions, it is widely connected to the rest of the neocortex and is involved in tasks that require temporal integration of information. ...

    • Improving animal models to understand gene regulation in human diseases 

      Mukarram, Abdul Kadir (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-10-29)
      The role of animal models in understanding biological processes and their dysregulations in humans is imperative and established in the research community. While extensive resources and knowledge on the genetic information ...

    • Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria 

      Chen, Xue (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-10-01)
      Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities ...

    • Gene regulation of acute insulin response in human adipose tissue in obesity and after weight-loss 

      Mileti, Enrichetta (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-09-10)
      The incidence and prevalence of obesity and type 2 diabetes is reaching epidemic proportions worldwide and insulin resistance, the pathophysiological link between the two conditions is consequently the focus of intense ...

    • A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1) in cancer 

      Song, Dandan (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-08-24)
      Activator protein-1 (AP-1) is a transcriptional factor complex that mainly consists of Fos and Jun family members. Jun proteins can form both homodimers and heterodimers, whereas Fos family members only form heterodimers ...

    • Characterization of the genome and tumor microenvironment of human B-cell lymphoma 

      Ye, Xiaofei (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-08-10)
      Non-Hodgkin lymphoma (NHL) is the 13th most common type of cancer worldwide in 2020 and consists mainly of human B-cell lymphoma (approximately 85%). Diffuse large B-cell lymphoma (DLBCL) is the most common NHL subtype ...

    • Network asynchrony underlying increased broadband gamma power 

      Guyon, Nicolas; Zacharias, Leonardo Rakauskas; de Oliveira, Eliezyer Fermino; Kim, Hoseok; Leite, João Pereira; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
      Synchronous activity of cortical inhibitory interneurons expressing parvalbumin (PV) underlies expression of cortical γ rhythms. Paradoxically, deficient PV inhibition is associated with increased broadband γ power in the ...

    • Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics 

      Guyon, Nicolas; Zacharias, Leonardo Rakauskas; van Lunteren, Josina Anna; Immenschuh, Jana; Fuzik, Janos; Märtin, Antje; Xuan, Yang; Zilberter, Misha; Kim, Hoseok; Meletis, Konstantinos; Lopes-Aguiar, Cleiton; Carlén, Marie (Inst för neurovetenskap / Dept of Neuroscience, 2021-05-31)
      Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network dynamics, generation of c oscillations, and cognition. Dysfunction of PV interneurons disrupts cortical information processing and cognitive ...

    • Objectively measured eating behaviors and their relation to food intake in school and hospital settings 

      Fagerberg, Petter (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-05-28)
      Introduction. The measurement of food intake (what and how much we eat and drink) is of great importance due to its involvement in three great challenges facing humanity: 1) obesity/overnutrition, 2) undernutrition and 3) ...

    • PAK4 in organ development and cancer initiation 

      Rabieifar, Parisa (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-05-28)
      Tumors are complex organs with a unique ecosystem containing tumor cells entangled with various infiltrating cells. Tumors have distinct signaling signatures, which confers upon it the ability to grow in the primary host ...

    • Estrogen receptor beta transcriptional regulation : a potential mechanism for colon cancer prevention 

      Indukuri, Rajitha (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-05-07)
      Colorectal cancer (CRC) is the third leading cause of death from cancer in both men and women in the Western world. Improved screening efforts, surveillance, and treatment have reduced CRC mortality in older patients. ...

    • Skin cell heterogeneity and dynamics during morphogenesis, tissue homeostasis, and regeneration 

      Jacob, Tina (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2021-03-31)
      Skin is our protective barrier against various environmental harms. For the skin to fulfill its crucial function, it relies on multiple cell types working in concert; but most importantly it relies on skin-resident epithelial ...

    • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age 

      Merid, Simon Kebede; Novoloaca, Alexei; Sharp, Gemma C; Küpers, Leanne K; Kho, Alvin T; Roy, Ritu; Gao, Lu; Annesi-Maesano, Isabella; Jain, Pooja; Plusquin, Michelle; Kogevinas, Manolis; Allard, Catherine; Vehmeijer, Florianne O; Kazmi, Nabila; Salas, Lucas A; Rezwan, Faisal I; Zhang, Hongmei; Sebert, Sylvain; Czamara, Darina; Rifas-Shiman, Sheryl L; Melton, Phillip E; Lawlor, Debbie A; Pershagen, Göran; Breton, Carrie V; Huen, Karen; Baiz, Nour; Gagliardi, Luigi; Nawrot, Tim S; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; Nohr, Ellen Aagaard; Bustamante, Mariona; Ewart, Susan L; Karmaus, Wilfried; Zhao, Shanshan; Page, Christian M; Herceg, Zdenko; Jarvelin, Marjo-Riitta; Lahti, Jari; Baccarelli, Andrea A; Anderson, Denise; Kachroo, Priyadarshini; Relton, Caroline L; Bergström, Anna; Eskenazi, Brenda; Soomro, Munawar Hussain; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; Jaddoe, Vincent W; Sørensen, Thorkild I A; Vrijheid, Martine; Arshad, S Hasan; Holloway, John W; Håberg, Siri E; Magnus, Per; Dwyer, Terence; Binder, Elisabeth B; DeMeo, Dawn L; Vonk, Judith M; Newnham, John; Tantisira, Kelan G; Kull, Inger; Wiemels, Joseph L; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Munthe-Kaas, Monica C; Räikkönen, Katri; Oken, Emily; Huang, Rae-Chi; Weiss, Scott T; Antó, Josep Maria; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catarina; Cardenas, Andres; Gruzieva, Olena; Xu, Cheng-Jian; Reese, Sarah E; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matthias; Holland, Nina; Ghantous, Akram; Hivert, Marie-France; Felix, Janine F; Koppelman, Gerard H; London, Stephanie J; Melén, Erik (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)
      Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...

    • Role of GPS2 in the regulation of adipocyte fate and function : a multi-omics approach 

      Barilla, Serena (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)
      The escalating prevalence of obesity and its association with comorbidities like insulin resistance and type 2 diabetes have raised the interest in adipose tissue biology and its therapeutic potential. Adipose tissue ...

    • Estrogen signaling in colon inflammation and colorectal cancer 

      Hases, Linnea (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-10-09)
      Colorectal cancer (CRC) is the third most deadly form of cancer in the Western world. Although screening efforts have reduced the overall mortality, the incidence is increasing among young adults. The frequency of inflammatory ...

    • Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential 

      Azatyan, Ani (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-08-13)
      Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog signaling ...

    • Exploring chromatin organization and transcription in S. pombe and hematopoietic development 

      Dong, Wenbo (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-05-28)
      DNA in the eukaryotic nucleus is organized into histone-DNA complex, so-called chromatin, through forming an array of nucleosomes. Each nucleosome consists of a 147bp DNA wrapped around a histone octamer harboring two of ...

    • Epigenetic regulation of transcription and cellular development 

      Shahin Varnoosfaderani, Farzaneh (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2020-03-11)
      Epigenetic machinery can regulate different biological processes via different mechanisms. In this thesis, we explore the effects of the epigenetic system on transcription and how it can differ during cellular development ...

    • PAK4 signaling in development and cancer 

      Costa, Tânia (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-10-17)
      Our understanding of cancer biology has been evolving rapidly shaped by groundbreaking discoveries. We now understand that cancer is not one disease but many, and that tumors are not foreign objects in the human body but ...

    • A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer 

      He, Huan (Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2019-09-27)
      Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy ...