Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics: Recent submissions
Now showing items 41-60 of 405
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The gut-brain axis in Parkinson’s disease : epidemiological studies on causes, underlying mechanisms and novel treatments
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-02-24)Parkinson’s disease (PD) is an age-related neurodegenerative disease with highly heterogeneous symptomatology. Little is known about why PD occurs. The gastrointestinal tract has been postulated as an origin of PD pathology, ... -
Depression in youth and adults : etiology, outcomes, and comorbidities
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-02-02)Depression is a common and debilitating mental disorder characterized by low mood, loss of interest in activities, and long-lasting functional impairment. It is a worldwide psychiatric illness with a wide range of ages of ... -
The development of psychiatric disorders and adverse behaviors : from context to prediction
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-28)Psychiatric disorders by definition cause significant impairment in an individual’s daily functioning. Certain disorders, such as borderline personality disorder (BPD) and eating disorders, have worse prognosis and high ... -
Medical and surgical treatment of inflammatory bowel disease
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-01-19)Inflammatory bowel disease (IBD), with its two main entities Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated ... -
Convergent etiology among schizophrenia, eating disorders, and other medical conditions
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)Schizophrenia and eating disorders (EDs) are complex traits with considerable somatic and psychiatric morbidity. Despite distinct diagnostic criteria and few symptoms in common, significant genetic correlations between ... -
Behavioural outcomes of treatment with selective serotonin reuptake inhibitors
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-12-13)Mood and anxiety disorders are some of the biggest contributors to morbidity worldwide, and may be lethal. Appropriate treatment is therefore paramount. Antidepressant medications constitute the primary pharmacological ... -
Drug safety and effectiveness in relation to kidney function : a pharmacoepidemiological approach
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-11)Kidney function plays an important role in drug safety and effectiveness. As many medications are excreted by the kidneys, patients with reduced kidney function are at a higher risk of supra-therapeutic or toxic drug levels. ... -
Etiology and early detection of pancreatic cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-11-08)Pancreatic cancer is one of the most dismal malignancies. Although its incidence and prevalence are relatively low, the disease burden is still an important health issue, especially in terms of mortality. Primary prevention ... -
An epidemiological study on nasopharyngeal carcinoma
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-25)Nasopharyngeal carcinoma (NPC) is a malignancy known for its unique geographic and ethnic distribution characterized by particularly high incidence in southern China, Southeast Asia, and North and East Africa, but being ... -
Biological ages : correlations, genetic determinants, and health outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-10-08)Population aging is a global trend and requires better evidence-based guidance. This thesis studied population aging from a molecular epidemiological angle. The overall work is centered on the “biological age (BA)”, which, ... -
Attention-deficit/hyperactivity disorder and educational outcomes : etiology, treatment effects, and occupational outcomes
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-08-12)Attention-Deficit/Hyperactivity Disorder is one of the most prevalent childhood-onset developmental disorders, and is associated with a wide range of problematic functional outcomes such as low educational attainment (EA), ... -
Improved statistical methodology for high-throughput omics data analysis
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-07-19)Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ... -
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ... -
Causes and consequences of stress and tobacco exposure in utero on birth size, asthma and academic achievement
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-03-01)The objective of this thesis was to further the understanding of the consequences of stress and smoking during pregnancy, the causes of intrauterine growth and asthma as well as the consequences of asthma on school performance ... -
Circulating proteins as predictors of cardiovascular mortality in endstage renal disease
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2021-02-24)Introduction: Proteomic profiling of end-stage renal disease (ESRD) patients could lead to improved risk prediction and novel insights into cardiovascular disease mechanisms. Plasma levels of 92 cardiovascular disease-associated ... -
Chlamydia trachomatis infection in Sweden : time trends, risk factors, and prevalence
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2021-02-18)Chlamydia trachomatis (chlamydia) infection is the most common bacterial sexually transmitted infection (STI), with an estimated 127 million new cases occurring every year worldwide. Due to the asymptomatic nature of the ... -
Risk assessment and prevention of breast cancer
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-12-21)One woman in eight develops breast cancer during her lifetime in the Western world. Measures are warranted to reduce mortality and to prevent breast cancer. Mammography screening reduces mortality by early detection. ... -
Attention-deficit/hyperactivity disorder and adverse health outcomes : from association to prevention
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-23)Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder, characterized by persistent inattention and/or hyperactivity-impulsivity that are inappropriate for one’s developmental ... -
Dietary habits, commensal microbiome, and nasopharyngeal carcinoma
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-19)Nasopharyngeal carcinoma (NPC) is a malignant disease characterized by unique geographic distribution endemic to southern China, Southeast Asia, and the Middle East/North Africa. It has been widely accepted that the ... -
Determinants and influence of mammographic features on breast cancer risk
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-11-16)Mammographic density and mammographic microcalcifications are the key imaging features in mammography examination. Mammographic density is known as a strong risk factor for breast cancer and is the radiographic appearance ...