Now showing items 1-20 of 267

  • Mitochondria targeting and its consequences for cell death in neuroblastoma 

    Valter, Kadri (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-12-14)
    Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. ...
  • The impact of transcriptional mutagenesis on cellular homeostasis 

    Ezerskyte, Monika (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-16)
    DNA is exposed to chemical and physical agents that represent a continuous threat to its integrity by formation of DNA lesions. Despite the existence and efficiency of DNA repair systems in cells, some lesions may not be ...
  • Early-life selenium status and cognitive development 

    Skröder Löveborn, Helena (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-12)
    Selenium is an essential element that is found in food sources such as meat, fish, and cereals. The essentiality of selenium was demonstrated in the 1950s, and the interest in its health effects has been growing ever since. ...
  • Cellular effects of nickel and nickel oxide nanoparticles : focus on mechanisms related to carcinogenicity 

    Åkerlund, Emma (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-11-02)
    There has been a rapid increase in the production and useage of nanomaterials during the last decade and therefore it is of great importance to properly investigate safety of these materials. This thesis specifically focuses ...
  • Innate immune airway responses after exposure to ultrafine and ambient particles : in vivo and in vitro models 

    Steneholm, Anna (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-10-04)
    Inhalation of ultrafine and ambient particles in the air triggers a response in the innate immune system of the airways. This thesis explores measures to reduce exposure to organic dust, to dampen the adverse immune effects ...
  • Quantification of inflammatory mediators to explore molecular mechanisms and sub-phenotypes of asthma 

    Kolmert, Johan (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-09-07)
    This thesis summarizes a series of studies using liquid chromatography coupled to mass spectrometry methodologies to quantify metabolites of fatty acids (i.e., oxylipins) and histamine in different samples from experimental ...
  • Evidence by interaction : a new role of caspase-2 

    Forsberg, Jeremy (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-08-10)
    Caspase-2 is the best conserved member of the caspase family. Although being known to mediate cell death following DNA damage, many studies have implicated that this protease regulates a variety of cellular processes. ...
  • Occupational skin exposure to cobalt : origin and fate 

    Kettelarij, Jolinde (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-25)
    Exposure to cobalt is not without risk. Besides adverse health effects on the respiratory system, cobalt is one of the most important sensitising metals with a contact allergy prevalence of 2.2% in the general population. ...
  • Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions 

    Ji, Jie (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-17)
    It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against ...
  • Characterizing chemical exposure : focus on children's environment 

    Larsson, Kristin (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-05-07)
    Children are constantly exposed to chemicals in food, water, dust, air and consumer products. Compared to adults, children often have a higher exposure to chemicals due to physical and behavioural factors. Because of their ...
  • Use of novel statistical methods in assessing particulate air pollution and evaluating its association with mortality in China 

    Fang, Xin (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-30)
    Particle matter (PM) has been associated with numerous adverse health effects including cardiovascular disease, chronic obstructive pulmonary disease and lung cancer in experimental studies and observation studies. The ...
  • Long-term exposure to transportation noise in relation to metabolic and cardiovascular outcomes 

    Pyko, Andrei (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-26)
    Transportation noise exposure is increasing because of rapid urbanization and transportation growth. Environmental noise exposure affects a large part of the population and gives rise to widespread annoyance and sleep ...
  • Neutrophil extracellular traps : function in infectious and non-Infectious conditions 

    Lazzaretto, Beatrice (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-04-12)
    Neutrophil extracellular traps (NETs) are composed of a backbone of chromatin, decorated with microbicidal peptides and proteolytic enzymes, and are used by neutrophils as a weapon against pathogens. Since their initial ...
  • Overweight in relation to allergic disease in childhood and adolescence 

    Ekström, Sandra (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-03-28)
    The prevalences of childhood overweight and allergic diseases have increased in parallel during the last decades. The overall aim of this thesis was to investigate the associations between overweight (maternal and childhood) ...
  • Mathematical programming for optimal probability weighting 

    Santacatterina, Michele (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-03-23)
    In spite of the fact that probability weighting is widely used in statistics to correct for unequal sampling, control for confounding, and handle missing data, it has two main limitations. First, statistical inferences ...
  • Short-term exposure to ozone in relation to mortality and out-of-hospital cardiac arrest : exploring sensitive subgroups by previous hospitalizations 

    Raza, Auriba (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-01-26)
    Background: Several epidemiological studies have associated short-term ozone (O3) exposure with mortality, as well as with out-of-hospital cardiac arrest (OHCA) and other morbidity. Knowledge on which parts of the general ...
  • Postmenopausal hormone therapy and cardiovascular risk 

    Carrasquilla, Germán D. (Institutet för miljömedicin / Institute of Environmental Medicine, 2018-01-09)
    Introduction and aims: Postmenopausal hormone therapy (HT) is the most effective treatment for menopausal symptoms, but its safety has been debated during the past 15 years. Previous observational studies showed benefits ...
  • Genes and brain tumors 

    Adel Fahmideh, Maral (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-12-19)
    Although brain tumors are rare and combined with other nervous system tumors account for ~ 2% of all cancers, they are the second most common type of pediatric cancer. The etiology of brain tumors, known as multifactorial ...
  • Occupational factors and risk of rheumatoid arthritis : studies on silica, physical workload and cold work environment 

    Zeng, Pingling (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-11-21)
    Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that could lead to joint destruction and disabilities. Around 30-70 million people worldwide are affected by RA. Both genetic and environmental factors ...
  • Experimental studies on acute health effects of acrolein and other aldehydes 

    Dwivedi, Aishwarya Mishra (Institutet för miljömedicin / Institute of Environmental Medicine, 2017-11-17)
    Aldehydes are reactive and ubiquitous in indoor as well as outdoors and can give rise to significant health problems in humans, e.g. irritation of the eyes and toxic effects on the upper respiratory tract. This thesis ...