Doktorsavhandlingar / Doctoral Theses - C2 (MBB): Recent submissions
Now showing items 1-20 of 300
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Lineage, cell state and cell identity in the developing human brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-04)Organisms are complex systems consisting of thousands of distinct types of cells that perform a wide array of functions, yet for the most part share the same DNA. To regulate the expression of genes, the genome contains a ... -
Development and function of GABAergic neurons in health and in a predisposition model of schizophrenia
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-03-21)In this thesis, I present four studies which examine i) the role of transcript factor Sox6 in the development and maintenance of cortical Sst interneurons, ii) the involvement of cortical neurogliaform cells (NGFCs) in the ... -
Imaging the spatial organization of healthy human brain and glioblastoma
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Multicellular biological systems have a single genetic plan that contains the set of instructions to shape the three-dimensional architecture of specialized tissues and organs. The genetic plan is contained in the DNA, and ... -
Regulation of mtDNA gene expression and the role of respiratory chain supercomplexes in mammalian mitochondria
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-22)Mitochondria are cellular organelles found in nearly all eukaryotic cells, where they fulfill a plethora of functions, including energy conversion. They harness energy from carbon sources to synthesize adenosine triphosphate ... -
The role of endoglin in vascular patterning and malformation across diverse vascular beds
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-01-09)During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of ... -
Impact of commonly prescribed drugs on the risk of colorectal cancer
(Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2023-11-23)Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for ... -
Beyond conventional care : developing novel therapeutic approaches to combat arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-10-30)Rheumatoid arthritis (RA) is an autoimmune disorder without a definitive cure. Although RA is driven by systemic autoimmunity, its most pronounced manifestation is organspecific inflammation, particularly synovitis in ... -
Novel methods of tandem mass spectrometry in life sciences
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-09-06)Mass spectrometry (MS) is a powerful analytical technique widely employed for isotopic analysis and species identification in numerous research fields. Isotopic analysis involves precisely measuring stable isotopes within ... -
Computational and chemical approaches to drug repurposing
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-08-31)Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two ... -
Functional screening and molecular characterisation of small proteins
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-08-23)Proteins are one of the main drivers of cellular function. Most known proteins constitute various hundred amino acids, but growing evidence suggests that additionally thousands of short open reading frames (sORFs) are ... -
Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-22)Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for ... -
Oxidative regulation of NCF1 in B cells and mouse models of arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-12)Autoimmune diseases (ADs) are chronic pathologies that result from a dysregulation of autoreactive B and T cells leading to autoantibody production and ultimately destruction of self. In paper I, we studied inflammation ... -
Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-11)RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over ... -
Identification and functional analysis of anti-citrullinated protein antibodies in rheumatoid arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-11)Rheumatoid arthritis (RA) is a complex autoimmune disease and typically manifested by joint inflammation and bone erosion with approximately 0.5% of the global population affected. To date, it is believed that genetic ... -
Unveiling the protective mechanisms of NOX2-derived ROS against autoimmune diseases
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-09)Autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), pose a significant burden on society, affecting a considerable portion of the global population. Both SLE and RA are known ... -
Characterisation of epitope-specific B cells and the role of IgG Fc sialylation in murine arthritis models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-05-03)Autoimmune diseases are a major burden for society and economy. One of the most common autoimmune diseases is rheumatoid arthritis (RA) characterized by joint inflammation, swelling and pain. If left untreated, it ultimately ... -
Developing molecular tools for probing and modulating genomic spatial adjacency
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-04-20)In addition to the vast information encoded in DNA sequence, the genome has physical features that are also essential for its function, including its organization in three-dimensional space. The development of high-throughput ... -
Custom-tailored DNA origami mechanics for cellular applications
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-02-22)DNA molecules have been used as the building block for the self-assembly of artificial nanostructures. In particular, the DNA origami method has made the design of DNA nanostructures more robust and approachable. Different ... -
Characterization of GTPBPs involved in ribosome assembly and function in human mitochondria
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-01-30)Mitochondria are organelles often referred to as the powerhouses of the cell as they provide most of the chemical energy via aerobic respiration. However, in the last half a century, it has become clear that their function ... -
Transcriptomic cellular diversity of the early human developing brain
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2023-01-27)The complexity of the mammalian brain is partly reflected in its cell type diversity which influences the function of neurons that encode the behavior of animals. Brain cell type diversity emerges during embryonic stages, ...