Now showing items 21-40 of 8206

    • Immunopathogenesis of multiple sclerosis : big roles for small RNAs 

      Piket, Eliane (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-21)
      Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and the leading cause of neurological disability in young adults. The exact cause of MS remains elusive despite enormous progress ...
    • FtsH protease and ClpG disaggregase confer fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C 

      Kamal, Shady Mansour (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2020-05-20)
      Pseudomonas aeruginosa is an environmental bacterium and a frequent nosocomial pathogen causing a wide range of opportunistic infections, especially in immunocompromised patients. Clone C is one of the most prevalent ...
    • Magnetic resonance imaging techniques for diagnostics in Parkinson’s disease and atypical parkinsonism 

      Sjöström, Henrik (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-20)
      Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history ...
    • Total hip arthroplasty, osteolysis and cardiovascular disease in patients with osteoarthritis of the hip 

      Rysinska, Agata (Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2020-05-20)
      The pathogenesis of OA and CVD is currently related to inflammatory processes. It is unknown how OA and its surgical treatment impact the cardiovascular system. Hypotheses We hypothesized that (1) THA ...
    • Outcome of gastric cancer surgery in Sweden 

      Kung, Chih-Han (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-20)
      Gastric cancer worldwide is the fifth most common cancer and has the third highest cancer related mortality. Curative treatment includes surgical resection but comes with risk of complications and the optimal surgery ...
    • Evaluation of biomarkers in chronic inflammatory diseases 

      Golabkesh, Zahra (Institutet för miljömedicin / Institute of Environmental Medicine, 2020-05-20)
      The overall aim of this thesis was to assess the role of biomarkers in chronic inflammatory disease. The goal of the first study was to investigate the association of sIL-6R and sgp130 levels and risk of first myocardial ...
    • Innate-like T cells in the immunopathogenesis of HIV-1 infection 

      Lal, Kerri Guth (Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-20)
      The immunodynamics of HIV infection have been studied for over three decades in the hopes of determining underlying mechanisms that contribute to the sustained immune dysfunction observed even in individuals on therapy. ...
    • Redesigning an emergency department for interprofessional teamwork : a longitudinal evaluation of the impact on patient flow and team behaviour 

      Liu, Jenny (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-19)
      Objective: Crowding in emergency departments (EDs) has negative effects on patients and staff, whereas effective teamwork in healthcare has positive effects. Triage interventions and streaming of specific patient categories ...
    • Etiology and prognosis of gastroesophageal cancers 

      Ekheden, Isabella (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2020-05-19)
      Gastric and esophageal cancer – gastroesophageal cancers, belong to the most fatal malignancies in the world. Understanding the cause of these diseases is key to interventions such as primary prevention and/or surveillance ...
    • From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes 

      Herzog Croona, Laura Katharina (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-18)
      Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, ...
    • Investigating and explaining sex differences in episodic memory 

      Asperholm, Martin (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-05-18)
      Sex differences can be seen in a lot of different areas, one of them being cognition where, among other things, men tend to perform better at more spatial tasks and women at more verbal. When it comes to episodic memory ...
    • Intralymphatic immunotherapy in allergic rhinitis : Evaluating safety, efficacy and mechanisms 

      Hellkvist, Laila (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Allergic rhinitis (AR) deprives work capacity, social activities and quality of life, and costs the Swedish society about €1.3 billion annually. Allergen-specific immunotherapy (AIT) amends the symptoms and improves the ...
    • New diagnostic approaches for venous thromboembolism and thrombophilia 

      Farm, Maria (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      Background: Venous thromboembolism is a serious disease comprising both pulmonary embolism and deep vein thrombosis. Venous thromboembolism causes considerable mortality and morbidity, with residual symptoms such as pulmonary ...
    • Glutamine kinetics in critically ill patients 

      Smedberg, Marie (Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2020-05-15)
      Critical illness, defined as a life-threatening organ failure, entails an extreme stress that results in a pathophysiology of its own. The abnormal metabolism of these patients causes a severe muscle wasting that is poorly ...
    • Surgeon-performed ultrasound and timing of surgery in acute cholecystitis 

      Gustafsson, Camilla (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2020-05-15)
      Introduction: The use of bedside ultrasound has increased, as equipment has become accessible, user friendly, and ultrasound education is expanding in many specialties. The aim of this project was to validate surgeon-performed ...
    • Methods for studying memory B-cell immunity against malaria 

      Jahnmatz, Peter (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)
      Plasmodium falciparum malaria remains one of the world’s deadliest infectious diseases and the search for an effective vaccine is highly warranted. Memory B cells (MBCs) and the antibodies they produce, once activated, ...
    • Applications of the golden angle in cardiovascular MRI 

      Fyrdahl, Alexander (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-15)
      The use of radial trajectories has been seen as a potential solution to highly efficient cardiovascular magnetic resonance imaging (MRI). By acquiring a broad range of spatial frequencies per repetition time, the acquisition ...
    • Prognosis based classification and tumor biology of uterine sarcomas 

      Hardell, Elin (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2020-05-15)
      Uterine stromal sarcomas are a heterogenous group of tumors ranging from low-grade stromal sarcomas with a relatively good survival but high risk of recurrence, to undifferentiated uterine sarcomas with a far worse ...
    • Psoriasis : from transcriptome to miRNA function and biomarkers 

      Pasquali, Lorenzo (Inst för medicin, Solna / Dept of Medicine, Solna, 2020-05-15)
      Psoriasis is a chronic inflammatory, immune-mediated skin condition that affects in average 2 to 3% of the world population, phenotypically characterized by red and scaly plaques on the skin of affected patients. It is a ...
    • Genetic causes and underlying disease mechanisms in early-onset osteoporosis 

      Kämpe, Anders (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2020-05-14)
      Adult-onset osteoporosis is a disorder that affects a significant proportion of the elderly population worldwide and entails a substantial disease burden for the affected individuals. Childhood-onset osteoporosis is a ...