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Genetic studies of atopic dermatitis
q35, 3q21, 5q31, 6p21, 11q13, and 14q11), previously implicated as candidate regions in atopic, diseases, and one new candidate gene, the gene for Wiskott- Aldrich syndrome located on Xp 11. These candidate genes were investigated in 572 affected sib...
Smoking cessation during pregnancy
recorded together with other background factors. In stated non-smokers, 13 had cotinine levels between 6 and 17.5ng/ml, suggesting substantial exposition to environmental smoke. 25 women who reported to be non-smokers had cotinine levels consistent...
STAT5 expression and regulation in mammary epithelial cells
) can activate latent cytoplasmic transcription factors of the signal transducer and activator of transcription (STAT) family of proteins. In particular the two STAT5 isoforms, STAT5A and STAT5B, are associated with effects of PRL. In this thesis...
Genetic and experimental studies of seasonal affective disorder and related phenotypes
expression, has been reported to be associated with both SAD and seasonality. In the present study, no association was found for this polymorphism, called 5-HTTLPR, or six other serotonin or signal transduction related gene variants. Analysis of additional...
Serotonergic mechanisms in atopic dermatitis
Atopic dermatitis (AD) may be worsened by stress and anxiety. Serotonin (5-hydroxytryptamine; 5-HT) is an important mediator in stress and anxiety. In the present thesis serotonergic mechanisms were studied in ...
Modulatory effects and interactions of substance P, dopamine and 5-HT in a neuronal network
cart be modulated by a tachykinin, dopamine and 5- HT that are co-localized in midline neurons situated below the central canal. * The midline neurons are rhythmically active during NMDA-induced fictive locomotion and are thus an integral part...
Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
those of PBDEs. Among the PBDEs, 2,2',4,4'-tetraBDE (BDE-47) was the predominant congener in breast milk, adipose tissue, matemal and cord blood, while in liver samples 2,2',4,4',5pentaBDE (BDE-99) occurred at similar concentrations as BDE- 47. The PCB...
Transcriptional mechanisms directing terminal differentiation of B lineage cells
factors critical for the development of B lineage cells have been identified. Some of these factors, Pax5, PU. 1, NF-kappaB and Oct-2, are instrumental in the work presented in this thesis. The immunoglobulin heavy chain 3 enhancer (HS1...
Molecular mechanisms of alternative estrogen receptor signaling
potentiate the transcriptional activity of Stat5 when Stat5 is bound to the beta-casein promoter upon prolactin stimulation. The potentiation of Stat5 activity did not require the presence of the AF-1 and AF-2 domains of the receptor, and was observed...