Quality of life and femoral neck fractures

The worldwide increase of hip fractures is a major challenge for the health care system and society. The treatment of femoral neck fractures in the elderly is still controversial, and even more so from an international perspective. Optimising the treatment for improved outcome and a reduced need for secondary surgery is mandatory for humanitarian and economical reasons. The importance of incorporating the patients's perspective of outcome in clinical trials is acknowledged and there are now numerous instruments for assessing the quality of life. We evaluated two quality of life instruments, the EQ-5D and the SF-36, in patients with femoral neck fractures and also measured the quality of life two years after different interventions.

In two prospective studies the EQ-5D was validated and it appeared to be an appropriate quality of life instrument in elderly patients with femoral neck fractures. There was a good correlation between the quality of life (EQ-5D index scores) and other outcome measures such as pain, mobility and independence in activities of daily living (ADL). The results also showed high responsiveness, i.e. ability to capture clinically important changes, for both the EQ-5D and the SF-36. The questionnaire response rate for both instruments was high.

The rated prefracture EQ-5D index scores showed good correspondence with the scores of an age- matched Swedish reference population. The quality of life in patients with femoral neck fractures treated with internal fixation (IF) decreased, particulary in patients with fracture healing complications. The fracture healing complications rate at two years in patients with displaced femoral neck fractures treated with IF was 36% compared to 7% in patients with undisplaced fractures. The quality of life of patients with uneventfully healed fractures at two year was significantly lower in patients with primarily displaced fractures compared with patients with undisplaced fractures.

In a prospective randomised trial patients with displaced femoral neck fractures were randomised to IF or a total hip replacement (THR). The failure rate after two years was higher in the IF group compared with the THR group with regard to hip complications, 36% and 4%, and the number of reoperated patients, 42% and 4%. Hip function and quality of life (EQ-5D) were generally better in the THR group. In summary, THR provided a better outcome than IF for an elderly, relatively healthy, lucid patient with a displaced femoral neck fracture.

In a study of elderly women with femoral neck fractures almost half of the patients displayed signs of protein-energy malnutrition. Underweight was associated with muscle fatigue, cognitive dysfunction and low quality of life (Nottingham Health Profile, NHP).

In a prospective randomised trial protein rich liquid supplementation in combination with an anabolic steroid given during 6 months to lean elderly women after a femoral neck fracture was shown to positively affect lean body mass, ADL and quality of life (EQ-5D). Fracture healing complications had a negative impact on body weight, lean body mass and quality of life.

List of scientific papers

I. Tidermark J, Zethraeus N, Svensson O, Tornkvist H, Ponzer S (2002). Femoral neck fractures in the elderly: functional outcome and quality of life according to EuroQol. Qual Life Res. 11(5): 473-81.
https://pubmed.ncbi.nlm.nih.gov/12113394

II. Tidermark J, Zethraeus N, Svensson O, Tornkvist H, Ponzer S (2002). Quality of life related to fracture displacement among elderly patients with femoral neck fractures treated with internal fixation. J Orthop Trauma. 16(1): 34-8.
https://pubmed.ncbi.nlm.nih.gov/11782631

III. Tidermark J, Bergstrom G, Svensson O, Tornkvist H, Ponzer S (2002). Responsiveness of the EuroQol (EQ-5D) and the SF-36 in elderly patients with displaced femoral neck fractures. Quality of Life Research.

IV. Tidermark J, Ponzer S, Svensson O, Soderqvist A, Tornkvist H (2002). Internal fixation versus total hip arthroplasty for displaced femoral neck fractures - a randomised controlled trial. Journal of Bone and Joint Surgery (Br). [Accepted]

V. Ponzer S, Tidermark J, Brismar K, Soderqvist A, Cederholm T (1999). Nutritional status, insulin-like growth factor-1 and quality of life in elderly women with hip fractures. Clin Nutr. 18(4): 241-6.
https://pubmed.ncbi.nlm.nih.gov/10578024

VI. Tidermark J, Ponzer S, Carlsson P, Soderqvist A, Brismar K, Tengstrand B, Cederholm T (2002). Effects of protein-richsupplementation and nandrolone in lean elderly women with femoral neck fractures. [Submitted]