Contemporary and future prostate cancer detection
The landscape of prostate cancer diagnostics and management continues to evolve, driven by efforts to balance early detection, minimize overdiagnosis, and enhance clinical outcomes. This thesis aims to examine critical aspects of this field, encompassing the relationship between lower urinary tract symptoms (LUTS) and prostate cancer, the validation of risk calculators, the integration of magnetic resonance imaging (MRI) in diagnostic pathways, and the implications of biopsy strategies.
The association between LUTS and prostate cancer was assessed in Study I, which is a population-based study involving men aged 50-69 years. Using data from the STHLM3 screening cohort, we compared International Prostate Symptom Score (IPSS) and biopsy outcomes and thereby the risk of prostate cancer. Among 45,595 men, 75% reported no or mild LUTS, and only 3% experienced severe symptoms. Also, men with high-risk prostate cancer (ISUP grade group ≥3 or cT ≥3) did not have higher IPSS values than those with benign biopsies. In multivariate logistic regression analysis, adjusting for age, PSA, prostate volume and clinical T-stage, there was no significant association between LUTS and prostate cancer risk. These findings challenge the assumption that prostate cancer commonly presents with worsening urinary symptoms, suggesting that reliance on LUTS for cancer suspicion may lead to unnecessary testing and overdiagnosis. Clinicians should instead focus on validated biomarkers and imaging tools for early detection.
The accurate prediction of prostate cancer risk is essential to optimize diagnostic and therapeutic decision-making. In Study II, we evaluated the Rotterdam Prostate Cancer Risk Calculator (RPCRC) and the Prostate Biopsy Collaborative Group Risk Calculator (PBCG-RC). We again used available data from the STHLM3 trial, identifying 5,841 men with PSA 23 ng/ml who underwent systematic biopsies. We assessed the performance of both RCs in predicting clinically significant prostate cancer (ISUP grade group ≥2) by calculating the risk for all men and comparing to biopsy outcome.
Both risk calculators exhibited good discriminatory ability, with area under the curve (AUC) values of 0.74 for the RPCRC and 0.70 for the PBCG-RC. The PBCG- RC demonstrated adequate calibration and clinical utility in its current form, offering a net benefit in decision curve analyses. In contrast, the RPCRC underestimated the risk of csPCa and showed no clinical benefit before recalibration. Recalibration of the RPCRC improved its performance, narrowing the differences between the two calculators. This study underscores the necessity of external validation and recalibration of risk prediction tools to ensure their reliability and applicability in various clinical settings.
The adoption of MRI before prostate biopsy has reshaped the field of prostate cancer diagnostics. MRI facilitates the detection of significant cancer by enabling targeted biopsies of suspicious lesions. In Study III we explored the implications of omitting systematic biopsies completely. Using data from the STHLM3-MRI screening trial, we included 395 men with either elevated PSA (>3 ng/ml) or Stockholm3 test (>11%) who had had a positive MRI (PI-RADS ≥3) followed by combined targeted and systematic biopsies. In total, 13% had ISUP grade group 1, and 58% had ISUP grade group ≥2 cancer. Omitting systematic biopsies decreased detection rates for both ISUP grade group 1 (risk ratio (RR) 0.83) and ISUP grade group ≥2 (RR 0.85) tumors. For every case of ISUP grade group 1 averted, there were 3.8 of missed ISUP grade group ≥2 and 1.1 ISUP grade group >3 cancer. Furthermore, omitting systematic biopsies increased the rate of misclassification at radical prostatectomy, with a higher proportion of men being upgraded following targeted-only biopsies compared to those receiving combined biopsies (31% vs. 19%, p <0.05). Assessing another strategy using PSA density >0.05 ng/ml2 as a threshold for biopsy yielded similar reductions in ISUP grade group 1 detection while improving the detection rates for clinically significant cancers. These findings highlight the need for future research to further improve biopsy strategies that would maximize cancer detection while minimizing overdiagnosis and misclassification.
In Study IV, we conducted a longitudinal, population-based study examining trends in prostate cancer diagnostics in the Stockholm region from 2010 to 2023. Using data from the Stockholm PSA and Biopsy Register, we included all men aged 40 years and older without a prior prostate cancer diagnosis. We analyzed how the use of PSA testing, MRI, and prostate biopsies evolved over time, particularly in the context of MRI being incorporated into the diagnostic pathway. We also examined changes in the distribution of ISUP grade groups on biopsy.
PSA testing remained common and stable throughout the study period, with 59% of all men - and over 75% of men aged 60 and above - being tested at least once. Following an elevated PSA, MRI usage increased markedly from 3% to 30%, while biopsy rates declined from 23% to 16% (RR 0.66; 95% CI: 0.64- 0.69)). By 2023, 83% of men undergoing biopsy had had a pre-biopsy MRI. Additionally, we observed a reduction in the proportion of benign biopsies and ISUP grade group 1 cancers, alongside a substantial increase in detection of ISUP grade group >2 cancers. These findings offer real-world evidence of improved diagnostic precision following the integration of MRI into routine clinical practice.
This thesis aims to give an overview in the rapidly evolving field of prostate cancer diagnostics. The four outlined studies discuss various aspects of patient selection, risk prediction and diagnostic strategies. In summary, they highlight the need for a more precise, evidence-based approach to improve clinical outcomes and reduce unnecessary interventions.
List of scientific papers
I. Chandra Engel J, Palsdottir T, Aly M, Egevad L, Grönberg H, Eklund M, Nordström T. Lower urinary tract symptoms (LUTS) are not associated with an increased risk of prostate cancer in men 50-69 years with PSA ≥3 ng/ml. Scand J Urol. 2020 Feb;54(1):1-6. https://doi.org/10.1080/21681805.2019.1703806
II. Chandra Engel J, Palsdottir T, Ankerst D, Remmers S, Mortezavi A, Chellappa V, Egevad L, Grönberg H, Eklund M, Nordström T. External Validation of the Prostate Biopsy Collaborative Group Risk Calculator and the Rotterdam Prostate Cancer Risk Calculator in a Swedish Population-based Screening Cohort. Eur Urol Open Sci. 2022 May 19;41:1-7. https://doi.org/10.1016/j.euros.2022.04.010
III. Chandra Engel J, Eklund M, Jäderling F, Palsdottir T, Falagario U, Discacciati A, Nordström T. Diagnostic Effects of Omitting Systematic Biopsies in Prostate Cancer Screening. Eur Urol Oncol. 2024 Oct 22:S2588-9311(24)00229-3. https://doi.org/10.1016/j.euo.2024.10.002
IV. Chandra Engel J, Rai B, Eklund M, Jäderling F, Clements M, Nordström T. Trends and patterns in prostate cancer diagnostics during the era of MRI implementation - real world evidence from a population-based study in the Stockholm Region, Sweden 2010- 2023. [Manuscript]
History
Defence date
2025-05-23Department
- Department of Clinical Sciences, Danderyd Hospital
Publisher/Institution
Karolinska InstitutetMain supervisor
Tobias NordströmCo-supervisors
Martin Eklund; Fredrik Jäderling; Thorgerdur PalsdottirPublication year
2025Thesis type
- Doctoral thesis
ISBN
978-91-8017-504-3Number of pages
61Number of supporting papers
4Language
- eng