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CMV-infection in gay men with AIDS

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posted on 2024-09-02, 18:48 authored by Sven Grützmeier

Background: Before the era of combination therapy (c-ART) more than 90 % of the patients with HIV-infection died of one or more opportunistic infections (OI). We and others noted early on that CMV was an important pathogen in these patients. We investigated the OIs related to causes of death in all Venhälsan patients, with these specific questions 1) All OIs and opportunistic cancers (OC)s in patients who died with CD4+ counts below 100 x 106/mL; 2) The prevalence of CMV encephalitis (CMV-E) and Korsakoff syndrome (Paper 1); 3) CMV retinitis (CMV-R) in relation to CMV-E (Paper II); 4) CMV adrenalitis (CMV-A) and its relation to CMV-R and CMV-E, including comparison of CMV assessment by PCR in blood and the Synacthen test; 5) The correlation between CMV disease and other OIs and OCs (Papers I, II and III); 6) The interaction between CMV, Epstein Barr virus (EBV) and other human herpes viruses in a case of anaplastic large cell lymphoma (ALCL) (Paper IV).

Material end methods: We followed all patients that died at Venhälsan from 1989-1996, with intensive blood testing, biopsies, culturing, X-ray, computer tomography CT, magnetic resonance imaging MRI as well as autopsy when permission was provided. We focused especially on Synacthen tests to diagnose CMV-A, neurological examinations to diagnose CMV-E and Korsakoff, and ophthalmologic examinations to diagnose CMV-R. In a case of anaplastic large cell lymphoma, we did extensive analysis of all human herpes viruses in the course of the disease.

Results: Of all 219 patients, that died with CD4+ < 100 x 106/mL 87% showed signs of reactivated CMV-infection. CMV-R was found in 84, CMV-E in 65, CMV-A in 41 and CMV in the gastrointestinal tract in 21. Mycobacterial infection was found in 87 and toxoplasmosis in 29. Kaposi’s sarcoma was the most common tumour (68 cases) followed by 22 patients with malignant lymphoma and 20 with CNS-lymphoma. CMV-reactivation was seen in most diagnostic. A case of primary CMV-infection leading to a malignant lymphoma by interaction with two other herpes viruses was also seen.

Conclusion: CMV-infection was the main OI in AIDS-patients during the pre-c-ART era and also the main cause of death by itself or together with other OIs. Reactivation of CMV was found in 87%. The most important CMV manifestations were CMV-R, CMV-E and CMV-A that seemed to occur at the same time. All of them have characteristic symptoms. Thus, when one of these is diagnosed investigation for the other two should be done. This is still today important in patients with CD4+ < 100 x 106/mL without access to modern HIV-treatment. These findings reveal the intimate interaction between HIV and CMV which should be considered in all co-infected patients also today.

List of scientific papers

I. Impairment of short-term memory and Korsakoff syndrome are common in AIDS patients with cytomegalovirus encephalitis. Pirskanen-Matell R, Grützmeier S, Nennesmo I, Sandström E, Ehrnst A. Eur J Neurol. 2009 Jan;16(1):48-53.
https://doi.org/10.1111/j.1468-1331.2008.02337.x

II. CMV-retinitis in relation to CMV-encephalitis in HIV-infected patients with CD4 cell counts < 100 x 106/mL. Sven Grützmeier, Bo Hedquist, Paniz Erfan, Börje Åkerlund, Eric Sandström, Ingemar Ernberg. [Submitted]

III. Cytomegalovirus-adrenalitis (CMV-A) in HIV-patients with CD4 counts < 100 x 106/mL - The value of ACTH-stimulating tests and blood CMV-PCR analysis. Sven Grützmeier, Johan Bergström, Börje Åkerlund, Torbjörn Lindström, Eric Sandström, Inger Nennesmo, Ingemar Ernberg. [Manuscript]

IV. Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection. Grützmeier S, Porwit A, Schmitt C, Sandström E, Åkerlund B, Ernberg I. Infect Agent Cancer. 2016 Aug 22;11:46.
https://doi.org/10.1186/s13027-016-0094-5

History

Defence date

2017-02-24

Department

  • Department of Microbiology, Tumor and Cell Biology

Publisher/Institution

Karolinska Institutet

Main supervisor

Ernberg, Ingemar

Publication year

2017

Thesis type

  • Doctoral thesis

ISBN

978-91-7676-600-2

Number of supporting papers

4

Language

  • eng

Original publication date

2017-02-03

Author name in thesis

Grützmeier, Sven

Original department name

Department of Microbiology, Tumor and Cell Biology

Place of publication

Stockholm

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