HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

https://hdl.handle.net/10616/ki.30618926

journal contribution

posted on 2025-11-14, 14:41 authored by Johan HolmbergJohan Holmberg, Oscar Bedoya ReinaOscar Bedoya Reina, Per KognerPer Kogner, Susanne SchlisioSusanne Schlisio

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Funding

Barncancerfonden (Swedish Childhood Cancer Foundation) | PR2023-0013

Cancerfonden (Swedish Cancer Society) | 23 3144 Pj

Vetenskapsrådet (VR) | VR2022-000731

National Microscopy Infrastructure : Swedish Research Council | 2019-00217_VR

History

File version

Published

Publication status

Published

Sub type

Article

Journal

Proc Natl Acad Sci U S A

ISSN

0027-8424

eISSN

1091-6490

Volume

122

Issue

43

Pagination

e2516922122-

Article number

e2516922122

DOI

http://doi.org/10.1073/pnas.2516922122

PubMed link

https://www.ncbi.nlm.nih.gov/pubmed/41118218

Language

eng

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Keywords

Adrenergic Neurons Basic Helix-Loop-Helix Transcription Factors Neuroblastoma N-Myc Proto-Oncogene Protein

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