Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

Dunlop, Malcolm G; Dobbins, Sara E; Farrington, Susan Mary; Jones, Angela M; Palles, Claire; Whiffin, Nicola; Tenesa, Albert; Spain, Sarah; Broderick, Peter; Ooi, Li-Yin; Domingo, Enric; Smillie, Claire; Henrion, Marc; Frampton, Matthew; Martin, Lynn; Grimes, Graeme; Gorman, Maggie; Semple, Colin; Ma, Yusanne P; Barclay, Ella; Prendergast, James; Cazier, Jean-Baptiste; Olver, Bianca; Penegar, Steven; Lubbe, Steven; Chander, Ian; Carvajal-Carmona, Luis G; Ballereau, Stephane; Lloyd, Amy; Vijayakrishnan, Jayaram; Zgaga, Lina; Rudan, Igor; Theodoratou, Evropi; Colorectal Tumour Gene Identification (CORGI) Consortium,; Starr, John M; Deary, Ian; Kirac, Iva; Kovacević, Dujo; Aaltonen, Lauri; Renkonen-Sinisalo, Laura; Mecklin, Jukka-Pekka; Matsuda, Koichi; Nakamura, Yusuke; Okada, Yukinori; Gallinger, Steven; Duggan, David J; Conti, David; Newcomb, Polly; Hopper, John; Jenkins, Mark A; Schumacher, Fredrick; Casey, Graham; Easton, Douglas; Shah, Mitul; Pharoah, Paul; Lindblom, Annika; Liu, Tao; Swedish Low-Risk Colorectal Cancer Study Group,; Smith, Christopher G; West, Hannah; Cheadle, Jeremy P; COIN Collaborative Group,; Midgley, Rachel; Kerr, David J; Campbell, Harry; Tomlinson, Ian P; Houlston, Richard S

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

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posted on 2024-10-22, 12:59 authored by Malcolm G Dunlop, Sara E Dobbins, Susan Mary Farrington, Angela M Jones, Claire Palles, Nicola Whiffin, Albert Tenesa, Sarah Spain, Peter Broderick, Li-Yin Ooi, Enric Domingo, Claire Smillie, Marc Henrion, Matthew Frampton, Lynn Martin, Graeme Grimes, Maggie Gorman, Colin Semple, Yusanne P Ma, Ella Barclay, James Prendergast, Jean-Baptiste Cazier, Bianca Olver, Steven Penegar, Steven Lubbe, Ian Chander, Luis G Carvajal-Carmona, Stephane Ballereau, Amy Lloyd, Jayaram Vijayakrishnan, Lina Zgaga, Igor Rudan, Evropi Theodoratou, Colorectal Tumour Gene Identification (CORGI) Consortium, John M Starr, Ian Deary, Iva Kirac, Dujo Kovacević, Lauri AaltonenLauri Aaltonen, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Koichi Matsuda, Yusuke Nakamura, Yukinori Okada, Steven Gallinger, David J Duggan, David Conti, Polly Newcomb, John Hopper, Mark A Jenkins, Fredrick Schumacher, Graham Casey, Douglas Easton, Mitul Shah, Paul Pharoah, Annika LindblomAnnika Lindblom, Tao Liu, Swedish Low-Risk Colorectal Cancer Study Group, Christopher G Smith, Hannah West, Jeremy P Cheadle, COIN Collaborative Group, Rachel Midgley, David J Kerr, Harry Campbell, Ian P Tomlinson, Richard S Houlston

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

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Published online

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Article

Journal

Nat Genet

ISSN

1061-4036

eISSN

1546-1718

Volume

44

Issue

7

Pagination

770-776

DOI

http://doi.org/10.1038/ng.2293

PubMed link

https://www.ncbi.nlm.nih.gov/pubmed/22634755

Language

eng

Original self archiving date

2013-02-07

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Keywords

Colorectal Neoplasms Cyclin-Dependent Kinase Inhibitor p21 DNA Polymerase III Membrane Proteins

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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

History

File version

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DOI

PubMed link

Language

Original self archiving date

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