Artiklar / Articles - C6 (IMM)
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Recent submissions
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Limited association between markers of stress during pregnancy and fetal growth in 'Born into Life' : a new prospective birth cohort
(Institutet för miljömedicin / Institute of Environmental MedicineInst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and BiostatisticsInst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 2023-01-17)Aims: We aimed to investigate the associations between perceived maternal stress or salivary cortisol levels during pregnancy and birthweight. Methods: In 2010-2012, we recruited 92 women living in Stockholm, Sweden, ... -
Number of siblings and survival from childhood leukaemia : a national register-based cohort study from Sweden
(Institutet för miljömedicin / Institute of Environmental Medicine, 2021-05-31)Background: Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of ... -
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-03-05)Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ... -
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ... -
Assessment of chronic bronchitis and risk factors in young adults : results from BAMSE
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2021-02-09)BACKGROUND: Chronic bronchitis is associated with substantial morbidity among elderly adults, but little is known about its prevalence and risk factors in young adults. Our aim was to assess the prevalence and early life ... -
Effects of inhaled corticosteroids on DNA methylation in peripheral blood cells in children with asthma
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2019-09-25) -
Cesarean delivery, preterm birth and risk of food allergy : nationwide Swedish cohort study of over 1 million children
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2019-08-06)Background & Objectives: Little is known about early life risk factors for food allergy in children. We examined the association between perinatal characteristics and future risk of food allergy in offspring. Methods: ... -
Allergen-specific IgE over time in women before, during and after pregnancy
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-11-26)The trajectory of IgE levels before, during and after pregnancy in sensitized individuals is characterized by significant increase in specific IgE to birch allergens but not to other allergens after multiple testing. This ... -
Does treating vascular risk factors prevent dementia and Alzheimer’s disease? A systematic review and meta-analysis
(Institutet för miljömedicin / Institute of Environmental Medicine, 2018-07-05)Background: Epidemiological evidence has associated Alzheimer’s disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain. Objective: To ... -
Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2018-01-11)Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric ... -
Sensitivity of Salmonella YG5161 for detecting PAH-associated mutagenicity in air particulate matter
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)The Salmonella/microsome assay is the most used assay for the evaluation of air particulate matter (PM) mutagenicity and a positive correlation between strain TA98 responses and benzo[a]pyrene (B[a]P) levels in PM has been ... -
Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo on mechanisms related to carcinogenesis. Of particular concern regarding exposure to complex PAH mixtures is how interactions ... -
Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular ... -
Benzo[a]pyrene-specific online high-performance liquid chromatography fractionation of air particulate extracts : a tool for evaluating biological interactions
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)Benzo[a]pyrene (B[a]P) is a known human carcinogen and is commonly used as a surrogate for assessing the carcinogenic risk posed by complex mixtures of polycyclic aromatic hydrocarbons (PAHs) present in air particulate ... -
Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are present in air particulate matter (PM) and have been associated with many adverse human health effects including cancer and respiratory disease. However, due ... -
Detection of benz[j]aceanthrylene in urban air and evaluation of its genotoxic potential
(Institutet för miljömedicin / Institute of Environmental Medicine, 2017-07-07)Benz[j]aceanthrylene (B[j]A) is a cyclopenta-fused polycyclic aromatic hydrocarbon with strong mutagenic and carcinogenic effects. We have identified B[j]A in air particulate matter (PM) in samples collected in Stockholm, ... -
Individual maternal and child exposure to antibiotics in hospital : a national population-based validation study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)Aim: Exposure to antibiotics in early life may affect future health. Most antibiotics are prescribed in outpatient care, but inpatient exposure is also important. We estimated how specific diagnoses in hospitals corresponded ... -
Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome : a randomized controlled trial
(Institutionen för klinisk neurovetenskap / Departement for clinical neuroscience, 2017-06-30)OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective ... -
Asthma and height in twins : a cohort and within-pair analyses study
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-06-14)In singletons, asthma may be associated with shorter height and delayed growth during adolescence. Yet, these studies do not account for heritability of asthma, puberty/menarche, and height. We aimed to study the association ... -
Marital status, education, and income in relation to the risk of esophageal and gastric cancer by histological type and site
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-05-10)BACKGROUND: Marital status, income, and education might influence the risk of esophageal and gastric cancer, but the literature is limited. A large study addressing subtypes of these tumors was used to clarify these ...