New aspects on timing and graft morbidity in anterior cruciate ligament reconstruction
Author: Essen, Christoffer von
Date: 2021-01-21
Location: Aulan, plan 6, hiss C, Södersjukhuset, Sjukhusbacken 10, Stockholm
Time: 14.00
Department: Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset
View/ Open:
Thesis (803.5Kb)
Abstract
The aim of this thesis was to investigate the effect of different surgical techniques on knee function and outcomes after an anterior cruciate ligament (ACL) reconstruction (ACLR).
In Study I, 70 patients with a Tegner level of six or more were assessed after randomisation between acute ACLR (within 8 days after the injury) and delayed ACLR (after normalised range of motion [ROM] 6–10 weeks after the injury) using a four-strand semi-tendinosus tendon graft. The primary endpoint was range of motion at three months, and in this first study the patients were followed up for six months. The results for stiffness, laxity, functional tests and functional scores were comparable for both groups. Patients who underwent delayed surgery had more muscle hypotrophy in the early phase of the rehabilitation process.
In Study II, 70 patients from the same randomised controlled trial as in Study I were assessed to compare total number of sick-leave days taken during the first year following an ACL rupture in those undergoing acute and delayed reconstruction as a means of measuring indirect socioeconomic costs. Acute reconstruction resulted in significant fewer sick-leave days during the first year after the injury. Acute and delayed ACL reconstruction provided similar clinical outcomes after 12 months with no significant differences.
In Study III, the patients in Study I were assessed at 24 months post-surgery. Twelve patients were lost to follow-up, six in each group. While no significant differences regarding outcome measurements between the groups could be found, both groups showed better functional outcome scores compared to the Swedish Knee Ligament Register (SKLR).
In Study IV, 140 patients were randomised between ipsilateral (IL) and contralateral (CL) four-strand semitendinosus tendon autograft and followed up for 24 months. The aim was to compare muscle strength and patient reported outcomes following ACLR using a semitendinosus (ST) graft from the IL leg compared to a graft from the CL leg and the primary endpoint was isometric hamstring strength at 6 months The results did not show any measurable subjective differences. The CL group showed early symmetrical strength between the limbs, while the IL group stayed asymmetrical during the whole trial with significant differences between the groups in both isometric and isokinetic strength.
In conclusion, acute ACLR can be performed safely without an increased risk of developing stiffness, and a reconstruction performed before recurrent giving ways occur increases the likelihood of achieving better functional scores. There is also, from a society viewpoint, a potential economic benefit to identifying individuals who would benefit from acute ACL reconstruction. Using a CL autograft is a safe option and could have benefits regarding regaining symmetrical strength between the limbs.
In Study I, 70 patients with a Tegner level of six or more were assessed after randomisation between acute ACLR (within 8 days after the injury) and delayed ACLR (after normalised range of motion [ROM] 6–10 weeks after the injury) using a four-strand semi-tendinosus tendon graft. The primary endpoint was range of motion at three months, and in this first study the patients were followed up for six months. The results for stiffness, laxity, functional tests and functional scores were comparable for both groups. Patients who underwent delayed surgery had more muscle hypotrophy in the early phase of the rehabilitation process.
In Study II, 70 patients from the same randomised controlled trial as in Study I were assessed to compare total number of sick-leave days taken during the first year following an ACL rupture in those undergoing acute and delayed reconstruction as a means of measuring indirect socioeconomic costs. Acute reconstruction resulted in significant fewer sick-leave days during the first year after the injury. Acute and delayed ACL reconstruction provided similar clinical outcomes after 12 months with no significant differences.
In Study III, the patients in Study I were assessed at 24 months post-surgery. Twelve patients were lost to follow-up, six in each group. While no significant differences regarding outcome measurements between the groups could be found, both groups showed better functional outcome scores compared to the Swedish Knee Ligament Register (SKLR).
In Study IV, 140 patients were randomised between ipsilateral (IL) and contralateral (CL) four-strand semitendinosus tendon autograft and followed up for 24 months. The aim was to compare muscle strength and patient reported outcomes following ACLR using a semitendinosus (ST) graft from the IL leg compared to a graft from the CL leg and the primary endpoint was isometric hamstring strength at 6 months The results did not show any measurable subjective differences. The CL group showed early symmetrical strength between the limbs, while the IL group stayed asymmetrical during the whole trial with significant differences between the groups in both isometric and isokinetic strength.
In conclusion, acute ACLR can be performed safely without an increased risk of developing stiffness, and a reconstruction performed before recurrent giving ways occur increases the likelihood of achieving better functional scores. There is also, from a society viewpoint, a potential economic benefit to identifying individuals who would benefit from acute ACL reconstruction. Using a CL autograft is a safe option and could have benefits regarding regaining symmetrical strength between the limbs.
List of papers:
I. Eriksson K, von Essen C, Jönhagen S, Barenius B. No risk of arthrofibrosis after acute anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2018 Oct;26(10):2875-2882.
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. von Essen C, McCallum S, Barenius B, Eriksson K. Acute reconstruction results in less sick-leave days and as such fewer indirect costs to the individual and society compared to delayed reconstruction for ACL injuries. Knee Surg Sports Traumatol Arthrosc. 2020 Jul;28(7):2044-2052.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. von Essen C, Eriksson K, Barenius B. Acute ACL reconstruction shows superior clinical results and can be performed safely without an increased risk of developing arthrofibrosis. Knee Surg Sports Traumatol Arthrosc. 2020 Jul;28(7):2036-2043.
Fulltext (DOI)
Pubmed
View record in Web of Science®
IV. von Essen C, Barenius B, Eriksson K. Utilizing a contralateral hamstring autograft facilitates earlier isokinetic and isometric strength recovery after anterior cruciate ligament reconstruction. [Submitted]
I. Eriksson K, von Essen C, Jönhagen S, Barenius B. No risk of arthrofibrosis after acute anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2018 Oct;26(10):2875-2882.
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. von Essen C, McCallum S, Barenius B, Eriksson K. Acute reconstruction results in less sick-leave days and as such fewer indirect costs to the individual and society compared to delayed reconstruction for ACL injuries. Knee Surg Sports Traumatol Arthrosc. 2020 Jul;28(7):2044-2052.
Fulltext (DOI)
Pubmed
View record in Web of Science®
III. von Essen C, Eriksson K, Barenius B. Acute ACL reconstruction shows superior clinical results and can be performed safely without an increased risk of developing arthrofibrosis. Knee Surg Sports Traumatol Arthrosc. 2020 Jul;28(7):2036-2043.
Fulltext (DOI)
Pubmed
View record in Web of Science®
IV. von Essen C, Barenius B, Eriksson K. Utilizing a contralateral hamstring autograft facilitates earlier isokinetic and isometric strength recovery after anterior cruciate ligament reconstruction. [Submitted]
Institution: Karolinska Institutet
Supervisor: Eriksson, Karl
Co-supervisor: Barenius, Björn
Issue date: 2020-12-28
Rights:
Publication year: 2020
ISBN: 978-91-8016-043-8
Statistics
Total Visits
Views | |
---|---|
New ... | 350 |
Total Visits Per Month
October 2023 | November 2023 | December 2023 | January 2024 | February 2024 | March 2024 | April 2024 | |
---|---|---|---|---|---|---|---|
New ... | 1 | 3 | 7 | 1 | 0 | 2 | 1 |
File Visits
Views | |
---|---|
Thesis_Christoffer_von_Essen.pdf | 233 |
Top country views
Views | |
---|---|
Sweden | 157 |
United States | 47 |
China | 34 |
Germany | 16 |
France | 9 |
Ireland | 9 |
Russia | 8 |
Turkey | 7 |
Finland | 5 |
South Korea | 5 |
Top cities views
Views | |
---|---|
Hangzhou | 19 |
Stockholm | 19 |
Bromma | 15 |
Sundsvall | 12 |
Ashburn | 9 |
Dublin | 9 |
Norrköping | 7 |
Umeå | 6 |
Kalmar | 4 |
Ludwigshafen am Rhein | 4 |