TFAM forces mtDNA to make a U-turn

Abstract

The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and imported into mitochondria, where it functions as an activator of mtDNA transcription and packages mtDNA into DNA-protein aggregates called mitochondrial nucleoids. Two X-ray crystallography studies in this issue reveal that TFAM shapes mtDNA into a sharp U-turn, thereby providing a molecular mechanism for its dual roles in the expression and maintenance of mtDNA.