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Artiklar / Articles - H5 (LABMED)

 

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  • Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles 

    Gupta, Dhanu; Wiklander, Oscar P B; Görgens, André; Conceição, Mariana; Corso, Giulia; Liang, Xiuming; Seow, Yiqi; Balusu, Sriram; Feldin, Ulrika; Bostancioglu, Beklem; Jawad, Rim; Mamand, Doste R; Lee, Yi Xin Fiona; Hean, Justin; Mäger, Imre; Roberts, Thomas C; Gustafsson, Manuela; Mohammad, Dara K; Sork, Helena; Backlund, Alexandra; Lundin, Per; de Fougerolles, Antonin; Smith, C I Edvard; Wood, Matthew J A; Vandenbroucke, Roosmarijn E; Nordin, Joel Z; El-Andaloussi, Samir (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2022-12-06)
    Extracellular vesicles (EVs) can be functionalized to display specific protein receptors on their surface. However, surface-display technology typically labels only a small fraction of the EV population. Here, we show that ...

  • Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress 

    Nilsonne, Gustav; Sun, Xiaojuan; Nyström, Christina; Rundlöf, Anna-Klara; Fernandes, Aristi Potamitou; Björnstedt, Mikael; Dobra, Katalin (Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2021-02-08)
    Malignant mesothelioma cells differentiate into sarcomatoid or epithelioid phenotypes. The sarcomatoid cell type is more resistant to chemotherapy and yields a worse prognosis. We have investigated whether selenite alone ...

  • Making proteins in the powerhouse 

    Hällberg, B Martin; Larsson, Nils-Göran (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2014-08-04)
    Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest as mitochondrial dysfunction is important in human pathology and ageing. Similar to the situation in bacteria, there is no ...

  • Ligation of human Fc receptor like-2 (FCRL2) by monoclonal antibodies downregulates B cell receptor mediated signaling 

    Shabani, Mahdi; Bayat, Ali-Ahmad; Jeddi-Tehrani, Mahmood; Rabbani, Hodjatallah; Hojjat-Farsangi, Mohammad; Ulivieri, Cristina; Amirghofran, Zahra; Tatiana Baldari, Cosima; Shokri, Fazel (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2014-05-27)
    B cell antigen receptor (BCR) signaling and its regulation through negative and positive regulators are critical for balancing B cell response and function. Human Fc receptor like-2 (FCRL2), a member of the newly identified ...

  • Inhibition of proteasome deubiquitinating activity as a novel cancer therapy 

    D'Arcy, Pádraig; Brnjic, Slavica; Olofsson, Maria Hägg; Fryknäs, Mårten; Lindsten, Kristina; De Cesare, Michelandrea; Perego, Paola; Sadeghi, Behnam; Hassan, Moustapha; Larsson, Rolf; Linder, Stig (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-04-22)
    Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit complex comprising a proteolytic 20S core particle capped by 19S regulatory particles. The approval of bortezomib for the treatment ...

  • Analysis of colorectal cancer morpohology in relation to sex, location and family history 

    Ghazi, Sam; Lindforss, Ulrik; Lindberg, Greger; Berg, Elisabeth; Lindblom, Annika; Papadogiannakis, Nikos; The Low-Risk Colorectal Cancer Study Group (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2013-02-13)
    Background: Studies of colorectal cancer (CRC) have suggested different mechanisms of carcinogenesis in men and women, young and old patients, right- and left sided tumors, and sporadic and familial tumors. These differences ...