Artiklar / Articles - C2 (MBB)
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Recent submissions
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Standardization of antigen-emulsion preparations for the induction of autoimmune disease models
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-09)Autoimmune murine disease models are vital tools for identifying novel targets and finding better treatments for human diseases. Complete Freund's adjuvant is commonly used to induce disease in autoimmune models, and the ... -
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, ... -
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-02-08)A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we ... -
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2021-12-14)Multiple sclerosis (MS) is a leading cause of incurable progressive disability in young adults caused by inflammation and neurodegeneration in the central nervous system (CNS). The capacity of microglia to clear tissue ... -
A DNA-nanoassembly-based approach to map membrane protein nanoenvironments
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ... -
X-chromosome upregulation is driven by increased burst frequency
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and BiophysicsInst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2020-05-12)Ohno's hypothesis postulates that X-chromosome upregulation rectifies X-dose imbalance relative to autosomal genes, present in two active copies per cell. Here we dissected X-upregulation into kinetics of transcription, ... -
Effects of design choices on the stiffness of wireframe DNA origami structures
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2019-04-24) -
Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2014-03-24)The glycosyltransferase SnogD from Streptomyces nogalater transfers a nogalamine moiety to the metabolic intermediate 3′,4′-demethoxynogalose-1-hydroxynogalamycinone during the final steps of biosynthesis of the aromatic ... -
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile
(Inst för medicin, Solna / Dept of Medicine, Solna, 2013-07-04)OBJECTIVES: To increase understanding of the aetiology and pathogenesis of rheumatoid arthritis (RA), genetic and environmental risk factors for RA subsets, defined by the presence or absence of different anticitrullinated ... -
Biochemical discrimination between selenium and sulfur 2 : mechanistic investigation of the selenium specificity of human selenocysteine lyase
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)Selenium is an essential trace element incorporated into selenoproteins as selenocysteine. Selenocysteine (Sec) lyases (SCLs) and cysteine (Cys) desulfurases (CDs) catalyze the removal of selenium or sulfur from Sec or ... -
Redox pioneer : Professor Arne Holmgren
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)Dr. Arne Holmgren (Ph.D., 1968) is recognized here as a redox pioneer, because he has published at least one article on redox biology that has been cited over 1000 times and has published at least 10 articles, each cited ... -
Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells : implications for oxidant-induced lung injury
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)Aims: Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans.We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in ... -
Biochemical discrimination between selenium and sulfur 1 : a single residue provides selenium specificity to human selenocysteine lyase
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-08)Selenium and sulfur are two closely related basic elements utilized in nature for a vast array of biochemical reactions. While toxic at higher concentrations, selenium is an essential trace element incorporated into ... -
Combining [(11)C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-02)BACKGROUND: In vivo imaging using Annexin A5-based radioligands is a powerful technique for visualizing massive cell death, but has been less successful in monitoring the modest cell death typically seen in solid tumors ... -
HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled sel-tagged affibody molecule
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2012-10-02)A rapid, reliable method for distinguishing tumors or metastases that overexpress human epidermal growth factor receptor 2 (HER2) from those that do not is highly desired for individualizing therapy and predicting prognoses. ...