Now showing items 21-25 of 25

    • Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile 

      Lundberg, Karin; Bengtsson, Camilla; Kharlamova, Nastya; Reed, Evan; Jiang, Xia; Källberg, Henrik; Pollak-Dorocic, Iskra; Israelsson, Lena; Kessel, Christoph; Padyukov, Leonid; Holmdahl, Rikard; Alfredsson, Lars; Klareskog, Lars (Inst för medicin, Solna / Dept of Medicine, Solna, 2013-07-04)
      OBJECTIVES: To increase understanding of the aetiology and pathogenesis of rheumatoid arthritis (RA), genetic and environmental risk factors for RA subsets, defined by the presence or absence of different anticitrullinated ...
    • The impact of birth mode of delivery on childhood asthma and allergic diseases : a sibling study 

      Almqvist, Catarina; Cnattingius, Sven; Lichtenstein, Paul; Lundholm, Cecilia (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2013-05-15)
      Background: Caesarean section (CS) has been reported to increase the risk of asthma in offspring. This may be due to that infants delivered by CS are unexposed to vaginal flora, according to the ‘hygiene hypothesis’. ...
    • Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes 

      Gyllenberg, Alexandra; Asad, Samina; Piehl, Fredrik; Swanberg, Maria; Padyukov, Leonid; van Yserloo, Brian; Graham, Jinko; Rutledge, Elizabeth; Orho-Melander, Marju; Lindholm, Eero; Graff, Caroline; Forsell, Charlotte; Åkesson, Karin; Landin-Olsson, Mona; Carlsson, Annelie; Forsander, Gun; Ivarsson, Sten; Larsson, Helena; Alfredsson, Lars; Åkesson, Kristina; Olsson, Tomas; Kockum, Ingrid; Lindblad, Bengt; Ludvigsson, Johnny; Marcus, Claude; Lernmark, Åke; McNeney, Brad; Swedish Childhood Diabetes Study Group; Diabetes Incidence in Sweden Study Group; Better Diabetes Diagnosis Study Group (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2013-03-25)
      The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to ...
    • Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses 

      Yan, Zhong-qun; Ketelhuth, Daniel F J; Rios, Francisco J O; Wang, Yajuan; Liu, Huiqing; Johansson, Maria E; Fredrikson, Gunilla N; Hedin, Ulf; Gidlund, Magnus; Nilsson, Jan; Hansson, Göran K (Inst för medicin, Solna / Dept of Medicine, Solna, 2013-02-05)
      Background: Subendothelial deposited low-density lipoprotein particles are a known inflammatory factor in atherosclerosis. However, the causal components derived from low-density lipoprotein are still poorly defined. ...
    • Immunotherapy with tolerogenic apolipoprotein B-100–loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice 

      Hermansson, Andreas; Johansson, Daniel K; Ketelhuth, Daniel F J; Andersson, John; Zhou, Xinghua; Hansson, Göran K (Inst för medicin, Solna / Dept of Medicine, Solna, 2011-05-31)
      BACKGROUND: Atherosclerosis is a chronic inflammatory disease characterized by a massive intimal accumulation of low-density lipoprotein that triggers chronic vascular inflammation with an autoimmune response to low-density ...