Long term magnetic resonance imaging : follow up after preterm birth
Author: Nagy, Zoltán
Date: 2009-06-09
Location: Skandiasalen, Astrid Lindgren Children s Hospital, KS, Solna
Time: 13.00
Department: Institutionen för kvinnors och barns hälsa / Department of Women's and Children's Health
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thesis.pdf (1.227Mb)
Abstract
Background: Since the introduction of neonatal intensive care units, the survival
after preterm birth has improved drastically and development after
preterm birth has become an area of intense research. Many studies have
found increased rates of neonatal and long term morbidity. In particular,
preterm birth has been identified as a risk factor for cognitive and
structural brain development and cardiovascular diseases. However, it is
also appreciated that the outcome after preterm birth depends on
antenatal, neonatal and postnatal care.
Aims: The aims of these studies were twofold: to use a range of MRI imaging techniques to investigate whether preterm born children and adolescents show differences in structural brain and aortic development as well as to compare these results to those reported from other countries, involving similar cohorts.
Subjects & Methods: The volunteers of interest in these studies were participants in the Stockholm Neonatal Project, which was initiated in 1988 as a prospective follow up study and included preterm infants if their weight at birth was less than or equal to 1500g. At 5½ years of age a group of term born children were selected as a control group. In a pilot study (Paper V) a subgroup of these individuals were examined. Papers I IV involve those 74 out of 182 ex preterm and 69 out of 125 control adolescents that were willing to participate. The participants underwent cranial MRI examinations at the MR Center at the Karolinska University Hospital to collect 3D anatomical images and diffusion tensor imaging data. In a subgroup of individuals, images were also collected of the descending aorta.
Results: In all studies we found preterm birth to be a risk factor for long term development. Ex preterm adolescents possessed more structural brain abnormalities mostly in the form of gliosis and white matter loss (Paper I). Their grey and white matter volumes were also lower with the most preterm showing the largest deviations from that of control adolescents (Paper II). Ex preterm adolescents also possessed large areas of thinner cortex (Paper III), hindered white matter microstructure (Papers II and V) and smaller diameters within their descending aortas (Paper IV).
Discussion: While these findings are not unprecedented, we found that with respect to brain the severity and extent of these findings was milder than that based on similar cohorts. It may be that the care provided to the preterm infants in the prenatal and neonatal periods resulted in these relatively moderate findings. Should that be the case, it is hopeful that further research will identify the appropriate care such that preterm born individuals may one day develop identically to those born at term.
Aims: The aims of these studies were twofold: to use a range of MRI imaging techniques to investigate whether preterm born children and adolescents show differences in structural brain and aortic development as well as to compare these results to those reported from other countries, involving similar cohorts.
Subjects & Methods: The volunteers of interest in these studies were participants in the Stockholm Neonatal Project, which was initiated in 1988 as a prospective follow up study and included preterm infants if their weight at birth was less than or equal to 1500g. At 5½ years of age a group of term born children were selected as a control group. In a pilot study (Paper V) a subgroup of these individuals were examined. Papers I IV involve those 74 out of 182 ex preterm and 69 out of 125 control adolescents that were willing to participate. The participants underwent cranial MRI examinations at the MR Center at the Karolinska University Hospital to collect 3D anatomical images and diffusion tensor imaging data. In a subgroup of individuals, images were also collected of the descending aorta.
Results: In all studies we found preterm birth to be a risk factor for long term development. Ex preterm adolescents possessed more structural brain abnormalities mostly in the form of gliosis and white matter loss (Paper I). Their grey and white matter volumes were also lower with the most preterm showing the largest deviations from that of control adolescents (Paper II). Ex preterm adolescents also possessed large areas of thinner cortex (Paper III), hindered white matter microstructure (Papers II and V) and smaller diameters within their descending aortas (Paper IV).
Discussion: While these findings are not unprecedented, we found that with respect to brain the severity and extent of these findings was milder than that based on similar cohorts. It may be that the care provided to the preterm infants in the prenatal and neonatal periods resulted in these relatively moderate findings. Should that be the case, it is hopeful that further research will identify the appropriate care such that preterm born individuals may one day develop identically to those born at term.
List of papers:
I. Nagy Z, Jonsson B (2009). "Cerebral MRI findings in a cohort of ex preterm and control adolescents." Acta Paediatrica. [Accepted]
Fulltext (DOI)
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II. Nagy Z, Ashburner J, Andersson J, Jbabdi S, Draganski B, Skare S, Böhm B, Smedler AC, Forssberg H, Lagercrantz H (2009). "Structural correlates of preterm birth in the adolescent brain". [Submitted]
III. Nagy Z, Lagercrantz H, Hutton C (2009). "The long term effects of preterm birth on cortical thickness". [Submitted]
IV. Edstedt Bonamy AK, Bengtsson J, Nagy Z, De Keyzer H, Norman M (2008). "Preterm birth and maternal smoking in pregnancy are strong risk factors for aortic narrowing in adolescence." Acta Paediatr 97(8): 1080-5.
Fulltext (DOI)
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V. Nagy Z, Westerberg H, Skare S, Andersson JL, Lilja A, Flodmark O, Fernell E, Holmberg K, Bohm B, Forssberg H, Lagercrantz H, Klingberg T (2003). "Preterm children have disturbances of white matter at 11 years of age as shown by diffusion tensor imaging." Pediatr Res 54(5): 672-9.
Fulltext (DOI)
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I. Nagy Z, Jonsson B (2009). "Cerebral MRI findings in a cohort of ex preterm and control adolescents." Acta Paediatrica. [Accepted]
Fulltext (DOI)
Pubmed
View record in Web of Science®
II. Nagy Z, Ashburner J, Andersson J, Jbabdi S, Draganski B, Skare S, Böhm B, Smedler AC, Forssberg H, Lagercrantz H (2009). "Structural correlates of preterm birth in the adolescent brain". [Submitted]
III. Nagy Z, Lagercrantz H, Hutton C (2009). "The long term effects of preterm birth on cortical thickness". [Submitted]
IV. Edstedt Bonamy AK, Bengtsson J, Nagy Z, De Keyzer H, Norman M (2008). "Preterm birth and maternal smoking in pregnancy are strong risk factors for aortic narrowing in adolescence." Acta Paediatr 97(8): 1080-5.
Fulltext (DOI)
Pubmed
View record in Web of Science®
V. Nagy Z, Westerberg H, Skare S, Andersson JL, Lilja A, Flodmark O, Fernell E, Holmberg K, Bohm B, Forssberg H, Lagercrantz H, Klingberg T (2003). "Preterm children have disturbances of white matter at 11 years of age as shown by diffusion tensor imaging." Pediatr Res 54(5): 672-9.
Fulltext (DOI)
Pubmed
View record in Web of Science®
Issue date: 2009-05-19
Rights:
Publication year: 2009
ISBN: 978-91-7409-451-0
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