Doktorsavhandlingar / Doctoral Theses - K2 (MedS)
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Recent submissions
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Novel diagnostic and prognostic tools in infiltrative cardiomyopathy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-16)Background: Heart failure is a severe medical condition, increasingly common in the aging population, causing both vast morbidity and mortality. Amongst different etiologies of heart failure, infiltrative cardiomyopathies ... -
From vaccination to infection : mechanistic studies of immune responses to SARS-CoV-2
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-04)The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 elevated population-level immunity and reduced ... -
Physiological and lifestyle-related cardiovascular risk factors for vessels, ventricle, and valve
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-04-03)Cardiovascular diseases are the most common cause of mortality globally, claiming twice as many lives as cancer and more than all nutritional disorders, infectious diseases, and maternal/neonatal conditions combined. The ... -
Heart failure with preserved and reduced ejection fraction : comorbidities, therapies and cause-specific outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-27)Background: Heart failure (HF) is associated with worse prognosis and poor quality of life, and its rising global prevalence puts a growing strain on healthcare systems. While most previous studies have focused on ... -
Diabetes, cardiovascular events, and lifestyle : from epidemiology to clinic
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-03-15)Today, the health care system plays an important role in the prevention of diseases, not least through support of a healthy lifestyle, including being physically active. Given the development of digital tools together with ... -
Gestational weight gain, bariatric surgery, and adverse maternal and infant outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-20)Gestational weight gain is a crucial predictor for various adverse maternal and infant outcomes. In 2009, the U.S. Institute of Medicine (IOM) introduced optimal ranges for gestational weight gain based on a woman's ... -
Prognostication in heart failure across the ejection fraction spectrum : implications for clinical practice and trial design
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-19)Background. The heterogeneity of heart failure (HF) across the ejection fraction (EF) spectrum presents a challenge when triaging for follow-up, implementing therapies, and designing trials. There is a preconceived notion ... -
Reproductive and lifestyle risk factors for sarcoidosis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-02-14)Sarcoidosis is a systemic inflammatory condition with an unknown origin, characterized by the formation of granulomatous lesions primarily in the lungs and lymphatic system. Despite over a century since it was first ... -
Understanding juvenile idiopathic arthritis : a multidimensional approach
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The overarching objective of this doctoral thesis is to enhance the understanding of Juvenile Idiopathic Arthritis (JIA), a complex autoimmune disease affecting children. With the aim of filling the knowledge gaps in JIA, ... -
Monitoring of the oral anticoagulants apixaban and rivaroxaban to optimize individual safety and efficacy
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-25)The oral anticoagulants apixaban and rivaroxaban are administered at fixed doses without requiring routine monitoring. However, there is a dose and exposure dependency in efficacy and safety, and monitoring the anticoagulants ... -
Comorbidities in early rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-23)All of the studies that form part of this thesis concern the subject of comorbid conditions in early rheumatoid arthritis (RA). We have used linkage of Swedish clinical and demographic registers as well as the Swedish ... -
The dimensions of human and murine CD8 T lymphocyte diversity
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-12)The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification ... -
Idiopathic inflammatory myopathies and cancer : familial risk, genetics and consequences
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-01-02)Idiopathic inflammatory myopathies (IIMs) are a group of rare rheumatic inflammatory diseases (RIDs), characterised by a diverse range of clinical, serological and histopathological characteristics, with muscle weakness ... -
From oral infection to autoimmunity : studies of antibodies and B cells on the path towards rheumatoid arthritis
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-12-08)Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial joints, which can lead to irreversible joint destruction and disability if not treated properly. The majority ... -
A study of immune dynamics in experimental arthritis using CRISPR and PET techniques
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-11-17)Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation associated with CD4 T cell dysfunction. The disease has no cure; thus, early diagnosis and interventions are crucial. DNMT3A ... -
Atopic dermatitis and distress
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-11-10)Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by itching, redness, and skin lesions, affecting approximately 10–20% of children and 1–3% of adults worldwide. Distress associated with AD ... -
Genetic risk factors in autoimmune Addison's disease
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-31)Autoimmune Addison’s disease is the most common form of primary adrenal insufficiency in the Western world. The low prevalence of the disease has hampered large-scale unbiased genetic studies where the entire genome could ... -
Deciphering the complexity of psoriasis : non-coding RNAs and cellular interactions
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-23)Psoriasis is a prevalent immune-mediated skin disorder marked by chronically relapsing inflammation and epidermal hyperproliferation. As researchers delve deeper into the molecular intricacies of psoriasis, emerging ... -
Studies on colonoscopy and inflammatory conditions of the colon
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-20)Background: Colonoscopy is a key investigative tool in inflammatory bowel disease and diverticular disease, but elements of the pathogenesis, symptomatology and safety of procedures in these two conditions remain unknown. ... -
Prediction and monitoring of in-hospital cardiac arrest
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-10-16)Background: In-hospital cardiac arrest (IHCA) is a global health concern of major importance, associated with a poor prognosis. IHCA is frequently heralded by a deterioration of vital signs, and many cases are considered ...