Licentiatavhandlingar / Licentiate Theses - H7 (MedH)
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Recent submissions
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Characterizing the effects of weight loss on human adipose tissue gene transcription and cell composition
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2023-05-05)Obesity is a globally prevalent metabolic disease that affects more than one billion people according to the World Health Organization and the number continues to increase. Obesity has detrimental effects on health and ... -
Common respiratory virus infections in cystic fibrosis : from immunity to vaccine
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2020-05-27)Cystic fibrosis is the most common lethal monogenetic disease in Caucasians. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein which is responsible for appropriate ion and water ... -
Weight loss programmes over the internet : opportunities and limitations
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-21)Background: Overweight and obesity is increasing in Sweden and over the world. The societal resources to treat obesity are scarce. Eighty percent of the population in Sweden have access to a computer and hence the Internet. ... -
Studies on the molecular regulation of bile acids and lipoproteins in human liver
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-23)Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only ... -
Studies of atherosclerosis in systemic lupus erythematosus
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2011-08-29)The role of inflammation in the development of atherosclerosis is now accepted and a focus of many studies because of its complex mechanisms. The risk of cardiovascular disease (CVD) and atherosclerosis is reported to be ... -
The effects of endothelin-1 in human adipose tissue
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2010-04-26)Obesity is a result of an imbalance between energy intake and energy expenditure ending in an excessive accumulation of body fat. Being overweight or obese increases the risk of death because of obesity related complications, ... -
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-17)The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ...