Licentiatavhandlingar / Licentiate Theses - H5 (LABMED)
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Recent submissions
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Is the clinical autopsy no longer relevant?
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2019-05-03)Background: The total number of autopsies has dropped during the last decades to less than a quarter of the number during the 1980-ies. We studied the consequences of a decrease in the autopsy frequency for the accuracy ... -
The use of computerised clinical decision support system in maternal and neonatal care in rural Africa : enthusiasm and concerns
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2017-12-15)Background: Maternal and neonatal mortality rates remain high in sub-Saharan Africa. The shortage of skilled Healthcare Workers (HCWs) and poor access to guidelines are plausible reasons for the reported low quality in ... -
The clinical usefulness of autopsies : roles and attitudes of health care providers
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2016-10-28)Background: The rate of autopsies has dropped to low levels in Western countries during the last four decades. In Sweden the rate of autopsy was 11% 2015. Aim: The overall aim of the project was to study the background ... -
Clinical studies of CYP3A4 and P-glycoprotein
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2016-10-12)In the field of pharmacokinetics, cytochrome P450 enzymes have been extensively studied. The CYP450 enzyme with the most drug substrates is CYP3A4, but despite its significance, administration of a specific substrate to ... -
Analysis of genomic data as an approach to understanding migration in song birds
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2015-01-23)Many species of birds migrate every year thousands of kilometers, relying on sight, memory, magnetic sensors and instincts to find their way across continents. Many juvenile birds travel complicated migration routes without ... -
Side-chain oxidized oxysterols as metabolic regulators in liver and brain
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2014-02-03)Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half-life and their ability to pass lipophilic membranes easily, thus they are considered as important intermediates in cholesterol excretion ... -
Prevention of liver cancer in chronic liver disease : an experimental study of sodium selenite and rat hepatocarcinogenesis
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2011-11-21)Selenium treatment in supranutritional but subtoxic doses has previously been shown to inhibit cell proliferation in preneoplastic lesions in a rat liver carcinogenesis model. The mechanisms are not known, but thioredoxin ... -
Studies of changes in volume in right ventricle with electrical bio impedance
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2002-12-12)In intracardiac impedance, electrical bio-impedance is measured inside the heart. This signal is known to reflect the volume of blood passing in and out of the ventricles. In transthoracic impedance the measurement current ... -
Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2011-05-18)Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about ... -
CYP2C19 and CYP2C9 geno- and phenotypes in healthy Swedish and Korean subjects
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2010-12-23)Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to affect the individual drug response. CYP2C19 and CYP2C9 ... -
The mammalian peroxisome : ‛its function and distribution’
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 2010-12-07)Peroxisomes are essential organelles for normal cell functions in all organisms from yeast to human. Their important contribution in different metabolic pathways is clearly visible by the severe phenotypes seen in the ... -
Detection of donor cells in recipient tissues after stem cell transplantation using FISH and immunophenotyping
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2007-05-04)Haematopoietic stem cell transplantation (HSCT) is curative therapy for many malignant and non-malignant diseases. Effective conditioning regimen is an important component of HSCT in order to achieve a successful engraftment ... -
Off-label drug treatment and related problems in children : a register-based investigation
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2006-04-21)Introduction: There is a lack of pediatric documentation concerning efficacy and safety of many drugs, which may contribute to off-label drug treatment and increase the risk for adverse drug reactions (ADRs). Aims: ... -
Analytical and pharmacological studies of cyclophosphamide
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2008-03-17)Pharmacokinetic and pharmacodynamic studies are an essential in order to achieve better treatment efficacy and less drug related toxicity. The kinetic studies depend on measuring the drug concentrations in body fluids. ... -
Development of a vaccine against strangles
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2005-09-16)Strangles is an acute upper respiratory tract disease in the horse, which is characterized by purulent pharyngitis and lymphadenitis. It is caused by Streptococcus equi subsp. equi. The severe suffering and economical ...