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  • The role of pairing beyond the seed in microRNA targeting 

    Kosek, David (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-03-01)
    MicroRNAs (miRNAs) are short non-coding RNAs which act as post-transcriptional regulators of gene expression. MiRNAs complex with Argonaute proteins to form an RNA-guided silencing complex (RISC). The guide RNA recognizes ...
  • Mechanisms driving notch disorders and therapeutic implications 

    Iqbal, Afshan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2024-02-21)
    Biliary tree is an intricate tubular structure lined by cholangiocytes or biliary epithelial cells. The differentiation, development and morphogenesis of bile ducts is controlled by Notch signaling and other pathways. ...
  • Lineage tracing of early organogenesis and liver mesenchymal cells with ultrasound-guided in utero nano-injection 

    He, Jingyan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-11-21)
    Current methods used to investigate embryo development and alter gene expression in mouse embryos are often time consuming and require large numbers of mice. To circumvent these limitations, we were aiming to develop a ...
  • Implementing new genomic tools to study ventral midbrain development and injury response in the newt Pleurodeles waltl 

    Yao, Zeyu (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-11-21)
    Mammals have a poor ability to regenerate organs or tissues. In particular, brain neurons do not regenerate after damage. A good example of this limitation is the irreversible degeneration of midbrain dopaminergic neurons ...
  • Fishing for small molecules to treat diabetes, from a beta cell perspective 

    Ren, Lipeng (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-10-27)
    Maintenance of glucose homeostasis necessitates a precise control of insulin secretion. Pancreatic β cells sense fluctuation of blood glucose and secret insulin in response. However, functional β cell mass is decreased in ...
  • Simultaneous profiling of cell types and lineages in neuro- and gliogenesis 

    von Berlin, Leonie (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-10-17)
    The mammalian brain consists of billions of highly specialized cells and trillions of connections between them. This immense complexity arises from a single layer of neuroepithelial progenitor cells. During development ...
  • Deciphering cell motility and spatial sensing of intestinal cell types using an ex vivo intestinal model 

    Webb, Anna (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-10-02)
    The intestine is a highly organized tissue with two distinct regions: the crypt and the villus. When stem cells divide at the crypt bottom, half of their progeny migrates upwards towards the villus, where they differentiate ...
  • An exPADItion for citrullination in the developing hair follicle 

    Vikhe Patil, Kim (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-08-31)
    During epidermal development, to assure proper tissue structure, highly complex transcriptional networks interact within the stem cell compartments of the epidermis and hair follicles (HFs) to balance the choice between ...
  • The trident of the pancreatic duct : stemness, morphogenesis and endocrinogenesis 

    Mi, Jiarui (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-29)
    Different subtypes of diabetes are all featured by the deterioration and loss of functional β-cell. Currently, there is still lack of therapeutic strategies to cure diabetes. However, harnessing the innate stem cell ...
  • Not just a pipe's dream : plumbing the contribution of cell diversity to oesophageal homeostasis 

    Grommisch, David (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-22)
    Epithelial barrier tissues like the skin, intestine, and oesophagus form a physical barrier that protects our body from external threats. To accurately fulfil their function, epithelial barriers are subject to constant ...
  • Principles of transcriptional bursting in mammalian cells 

    Larsson, Anton (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-22)
    In mammalian cells, transcription occurs in discrete bursts leading to fluctuations in transcripts from expressed genes. Although this behavior was first reported not long after the discovery of messenger RNA (mRNA), the ...
  • Epidermal stem cells at the point of no return 

    Annusver, Karl (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-05-17)
    The skin is our main barrier against outside harm, and it helps to maintain internal homeostasis. These functions are mostly fulfilled by the epidermis, which is the outermost layer of the skin, formed from keratinocytes ...
  • Studies on genetic and epigenetic regulation of gene expression dynamics 

    Hartmanis, Leonard (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-03-10)
    The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes ...
  • Investigating novel roles of topoisomerase regulatory interactions in transcription 

    Kuzin, Vladislav (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2023-01-25)
    Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, ...
  • Fibrosis in the central nervous system : the role of perivascular cells 

    Holl, Daniel (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-11-25)
    Regeneration in the adult mammalian central nervous system (CNS) is very limited. One limiting factor is the formation of chronic scar tissue, which inhibits axonal regeneration and functional recovery. While scar formation ...
  • Translational studies of epithelial cancer 

    Classon, Johanna (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-11-16)
    Tumors stemming from specialized epithelial cells cause the most common cancer types and are among the leading causes of death in the western world. Although great strides have been made in early cancer detection, defining ...
  • Degradation and sequestration : cellular strategies to counteract proteotoxic stress 

    Xu, Shanshan (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-10-06)
    Maintenance of proteome homeostasis (proteostasis) is essential to preserve cellular function in response to intrinsic and extrinsic stress conditions. This is regulated by the proteostasis network, which is comprised of ...
  • Generation of cell diversity in the developing brainstem and its modeling in vitro 

    Kozhevnikova, Mariya (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-09-26)
    The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional ...
  • Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure 

    De Genst, Erwin; Foo, Kylie S; Xiao, Yao; Rohner, Eduarde; de Vries, Emma; Sohlmér, Jesper; Witman, Nevin; Hidalgo, Alejandro; Kolstad, Terje R S; Louch, William E; Pehrsson, Susanne; Park, Andrew; Ikeda, Yasuhiro; Li, Xidan; Mayr, Lorenz M; Wickson, Kate; Jennbacken, Karin; Hansson, Kenny; Fritsche-Danielson, Regina; Hunt, James; Chien, Kenneth R (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-19)
    The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca2+ ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. ...
  • Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy 

    Beverborg, Niels Grote; Spater, Daniela; Knoll, Ralph; Hidalgo, Alejandro; Yeh, Steve T; Elbeck, Zaher; Sillje, Herman H W; Eijgenraam, Tim R; Siga, Humam; Zurek, Magdalena; Palmer, Malin; Pehrsson, Susanne; Albery, Tamsin; Bomer, Nils; Hoes, Martijn F; Boogerd, Cornelis J; Frisk, Michael; van Rooij, Eva; Damle, Sagar; Louch, William E; Wang, Qing-Dong; Fritsche-Danielson, Regina; Chien, Kenneth R; Hansson, Kenny M; Mullick, Adam E; de Boer, Rudolf A; van der Meer, Peter (Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 2022-08-18)
    Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. ...

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