Doktorsavhandlingar / Doctoral Theses - C4 (Neuro)
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Recent submissions
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Organic electronics and microphysiological systems to interface, monitor, and model biology
(Inst för neurovetenskap / Dept of Neuroscience, 2024-02-06)Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand ... -
Epigenetic and bioelectronic tools to study neural stem cells in health and disease
(Inst för neurovetenskap / Dept of Neuroscience, 2023-11-10)Brain development is a highly controlled, complex, and dynamic process. The mechanisms of its control need to accommodate the constantly changing contexts which, overtime, support the emergence of new neural structures ... -
On learning in mice and machines : continuous population codes in natural and artificial neural networks
(Inst för neurovetenskap / Dept of Neuroscience, 2023-10-30)Neural networks, whether artificial in a computer or natural in the brain, could represent information either using discrete symbols or continuous vector spaces. In this thesis, I explore how neural networks can represent ... -
Mechanisms of motor and non-motor complications in experimental parkinsonism
(Inst för neurovetenskap / Dept of Neuroscience, 2023-10-02)Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is classically characterized by the progressive loss of midbrain dopaminergic neurons and by the emergence of cardinal motor symptoms including ... -
Mitigating neuroinflammation : new potential therapeutics and targets
(Inst för neurovetenskap / Dept of Neuroscience, 2023-05-29)Neurodegenerative disorders, from chronic diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) to more acute injuries such traumatic brain injury (TBI), present a particular challenge to public health ... -
On striatum in silico
(Inst för neurovetenskap / Dept of Neuroscience, 2023-05-22)The basal ganglia are a collection of subcortical nuclei involved in movement and action selection. The striatum is the main input nucleus with extensive projections from the cortex and thalamus, and dopaminergic projections ... -
Body perception and brain plasticity in blind and sighted individuals
(Inst för neurovetenskap / Dept of Neuroscience, 2023-04-28)Lack of vision is associated with large-scale brain plasticity. Vision, touch, proprioception, interoception, and other sensory modalities are thought to play a vital role in developing and maintaining bodily awareness. ... -
Novel fluorescent tools and techniques for 3D imaging of the cleared brain
(Inst för neurovetenskap / Dept of Neuroscience, 2023-02-23)Background: To better understand the complexity of the brain and how it becomes impaired under different pathological states, a considerably large number of brains would be needed for imaging to generate highly detailed ... -
Multiple circuits controlling the versatility of locomotion : molecular and connectivity principles in zebrafish
(Inst för neurovetenskap / Dept of Neuroscience, 2022-11-24)Locomotion is produced by neuronal circuits in the spinal cord. These motor circuits rely on the activation of supraspinal centres and transform descending excitatory drive into coordinated rhythmic activity. Far from ... -
The molecular basis of spiral ganglion neurons : diversity and development
(Inst för neurovetenskap / Dept of Neuroscience, 2022-10-03)Hearing, one of our main senses, allows us to socialize, listen and enjoy sounds around us. The critical transmitters of the sound information are the spiral ganglion neurons (SGNs); located in the cochlea, they transmit ... -
Alterations in circadian entrainment : translational value in major depression
(Inst för neurovetenskap / Dept of Neuroscience, 2022-09-09)Adverse conditions of different origin occurring during development can have a negative impact on the nervous system and increase risk for the onset of mental disorders. In mice prenatal exposure to excess glucocorticoids ... -
Principles of regional covariance in brain structure
(Inst för neurovetenskap / Dept of Neuroscience, 2022-08-31)The human brain varies between individuals in both shape and size. These variations are not unique for each brain region. This causes grey matter density between regions to covary, a phenomenon known as “structural brain ... -
Escaping the riptide : probing the malleability of cognition
(Inst för neurovetenskap / Dept of Neuroscience, 2022-05-25)Cognitive abilities are essential for functioning in daily life – even something as mundane as going to the grocery store taps into a variety of cognitive functions. Exactly how and under what circumstances they can be ... -
Diversity of striatal interneurons : connectivity and functions
(Inst för neurovetenskap / Dept of Neuroscience, 2022-05-25)Multisensory integration of cortical and thalamic inputs by the striatal network, and its modulation by local acetylcholine and midbrain dopamine, are crucial components of movement control and striatal function. A flexible ... -
A critic in action? A functional examination of the Striato-Pallido-Habenular circuit
(Inst för neurovetenskap / Dept of Neuroscience, 2022-05-19)The basal ganglia (BG) and the midbrain dopamine (DA) system are considered key loci of reinforcement learning (RL), or learning by "trial and error", in the brain. The BG are implicated in action selection, and thus the ... -
The dynamics of intra- and inter-organ communication during an acute kidney infection
(Inst för neurovetenskap / Dept of Neuroscience, 2022-01-27)This thesis focuses on the roles of neuro-immune communication and infection-mediated coagulation during bacterial kidney infections. We demonstrate dynamic intra- and inter-organ host responses, where the outcome of an ... -
Deciphering the role of genetics and circadian rhythm in cluster headache
(Inst för neurovetenskap / Dept of Neuroscience, 2021-05-28)Cluster headache (CH) is a complex neurovascular disorder with a distinct circadian attack pattern. Although many aspects of the disease’s pathophysiology remain to be elucidated, it is likely caused by a combination of ... -
On the role of parvalbumin interneurons in neuronal network activity in the prefrontal cortex
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-30)The prefrontal cortex (PFC) is an area important for executive functions, the initiation and temporal organization of goal-directed behavior, as well as social behaviors. Inhibitory interneurons expressing parvalbumin (PV) ... -
The molecular basis of the development and diversity of proprioceptive neurons : a story of surviving and thriving
(Inst för neurovetenskap / Dept of Neuroscience, 2021-04-21)Proprioception, also known as the sixth sense, describes the sensation of our body position and movement. Its proper function is essential for our daily activities from coarse movements, e.g. locomotion, to precise movements, ... -
Bacterial sensors and controllers based on organic bioelectronics
(Inst för neurovetenskap / Dept of Neuroscience, 2021-01-14)Bacterial infections and contaminations are worldwide problems, leading to morbidity and mortality, food waste and economic losses in a variety of industries. The situation is aggravated by the increased occurrence of ...