Doktorsavhandlingar / Doctoral Theses - C3 (FyFa): Recent submissions
Now showing items 21-40 of 320
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Exploration of novel hepatic In-vitro systems for drug metabolism and pharmacokinetic studies
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-03-24)The development of a novel drug is a highly cost-intensive and risky process and many drug candidates fail on the way to final approval. An important task during this development is to investigate the absorption, distribution, ... -
Objective diagnostics of tinnitus
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-03-02)Background: Tinnitus is the phantom perception of sound reported by around 14% of the population. For over 120 million people worldwide tinnitus is perceived as a major problem. Still, tinnitus is a heterogenous condition ... -
Complement mediated synapse elimination in schizophrenia
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2023-02-23)Schizophrenia (SCZ) is a devastating psychiatric disorder with a typically age of onset in late adolescence. The heritability is estimated to be in between 60-80% and large-scale genome-wide studies have revealed a prominent ... -
Studies of experimental brain trauma and ischemia : effects of Epo
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-12-22)Traumatic brain injury has attained a lot of scientific and clinical focus during a considerable amount of time but is still as of today regarded a highly lethal condition with a high degree of morbidity amongst the ... -
Aspects of circulatory failure in respiratory extracorporeal membrane oxygenation
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-12-16)Extracorporeal Membrane Oxygenation (ECMO) was developed in the seventies for the intended use of supporting respiratory failure. Today ECMO has become a well-established treatment for patients with both respiratory and ... -
Venous thrombosis in children : the roles of vascular access and critical illness
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-11-18)Venous thromboembolism (VT) is a rare event in the general pediatric population. However, the incidence in hospitalized children is higher and has increased dramatically reaching 58 per 10 000 children. The single most ... -
The circuit and synaptic organization of the basal ganglia output : mechanistic insights on movement disorders and action control
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-10-18)Understanding the neural circuitry underlying movement is a neuroscientific challenge that promises to help refining currently available treatments for movement disorders. Key structures for movement and action control are ... -
Clinical applications of MRI in the diagnosis of pulmonary embolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-09-30)Pulmonary embolism (PE) is a potentially serious medical condition and is the third most common cause of death among cardiovascular diseases. The diagnosis of PE is made with imaging due to its nonspecific clinical signs ... -
Environmental and genetic risk factors for tinnitus
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-09-05)Tinnitus is a phantom auditory sensation, most often referred to as “ringing in the ears” with detrimental effect on quality of life. Between 4% and 37% of the global population has experienced tinnitus at some point in ... -
Single-cell transcriptomic analyses of early embryonic development and developmental programming by androgen excess
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-08-18)Infertility is a compelling problem an increased prevalence among couples. Although multiple causes have been hypothesized to increase the risk of infertility, changes in lifestyles and environment are the possible links ... -
Pediatric caudal anesthesia with reference to spread and intracranial effects
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-05-25)Background: Caudal anesthesia is, since 1933, the most common regional anesthetic technique used in children and has hitherto been described as a safe and straightforward method. Recent research has shown that a high-dose ... -
The role and regulation of nitric oxide and oxidative stress in cardiometabolic disease : focus on preeclampsia
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-04-29)Cardiovascular (CVD) and metabolic diseases account for significant morbidity and mortality. Over the last decades, despite significant research and clinical effort, their global prevalence is estimated to further increase. ... -
Functional and metabolic alterations in skeletal muscle in response to physiological and pathophysiological stressors
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-04-07)Skeletal muscle performance is essential for our body’s movement as well as for the wholebody metabolism. In health and disease, skeletal muscle is exposed to various endogenous and exogenous stressors, influencing its ... -
Physiological effects of apnoeic oxygenation using high-flow nasal oxygen
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-04-05)In anaesthetic practice, the inability to oxygenate and ventilate patients is a much-feared complication with risk for severe hypoxia-induced adverse outcomes. By administrating oxygen in the absence of spontaneous ... -
Assessing the impact of modulating protein degradation pathways in cancer
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-03-31)Proteins are macromolecules, essential constituents of the cells with various functions, such as providing structure to the cells, performing biochemical reactions, transporting molecules. The levels of cellular proteins ... -
Deep learning in breast cancer screening
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-03-09)Breast cancer is the most common cancer form among women worldwide and the incidence is rising. When mammography was introduced in the 1980s, mortality rates decreased by 30% to 40%. Today all women in Sweden between 40 ... -
Antibody- and osteoclast-dependent mechanisms of chronic pain
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-02-14)Chronic pain is a frequent condition that affects approximately 20% of worldwide population with a higher prevalence among women. Due to the lack of optimal treatment, chronic pain leads to decreased life quality as well ... -
Nitric oxide in cardiovascular and renal disease : role of organic nitrates, inorganic nitrate and red blood cells
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-02-03)RATIONALE: Cardiovascular and renal disorders are major health problems, which are often co-existing. Mechanistically, these conditions can be attributed to endothelial dysfunction, a process coupled with reduced nitric ... -
Mitochondria and its role in metabolic regulation and skeletal muscle function in healthy and disease conditions
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-02-02)Skeletal muscle function is critical for our overall health and to be able to perform daily activities. Skeletal muscle has the ability to adapt to various stimuli and mitochondria are known to play an important role in ... -
Perioperative management and molecular patterns in patients with obstructive sleep apnea
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2022-01-20)Obstructive sleep apnea (OSA) is a common disorder, both in the general and surgical population. While there is a steadily increased awareness of the disorder both in the society as a whole and within health care, ...